PyIgClassify: An antibody CDRs clusters web site

FCCC

Clusters of Antibody CDR Loop Conformations

Dunbrack Lab

Summary info for CDR clusters

H1

Loop	# of Structures	% of Loop Length	Median PDB	Consensus Sequence	# of Unique Seq	% of Unique Seq	Species	Gene	Loop Conformation	Median Angle	Consensus Sequence Logo
H1-10-1	8	88.89	1KXQF	aaSeytyrmG	5	83.33	CDRLenMismatch	heavy	PBABPBABBB	14
H1-12-1	3	33.33	1GHFH	KagfnfkDvgMn	2	33.33	CDRLenMismatch	heavy	PBABPAAABBBB	31
H1-13-1	2620	76.92	1RURH	aaSGfsfsdywih	1065	70.16	Al Bo Ca CDRLenMismatch Ch Ha Hu La Ma Mf Mo Ra Rb Sh	heavy	PBBLBPAAABPBB	16
H1-13-2	59	1.73	1UWGY	aasggtisdyaig	48	3.16	Al Ca Hu La Mo Ra	heavy	BBADBPAAABPBB	27
H1-13-3	86	2.52	1U0QA	aasgrtfssyaig	62	4.08	Al Ca Hu La Mf Mo Sh	heavy	PBPGDDAAABPBB	31
H1-13-4	108	3.17	1IC4H	aasGgsfsgygis	42	2.77	Al Hu La Mf Mo Rb	heavy	PPBLBBAPLBBBB	25
H1-13-5	46	1.35	1MVFA	aaSGsifsi-amg	35	2.31	Al Ca La	heavy	PPBGPAAAPDBBB	22
H1-13-6	27	0.79	2P45B	aaSGsifssivmg	16	1.05	Al Ca Hu La Mo	heavy	BBBLPABPPABBB	27
H1-13-7	36	1.06	1DQDH	kasGdsftsgfmn	19	1.25	Hu La Mf Mo	heavy	PBBLBPAABGBBB	22
H1-13-8	51	1.50	1HCVA	aASGaTgssddig	5	0.33	Hu La Mo	heavy	PBBGLBGAABBBB	38
H1-13-9	6	0.18	1KXVD	AASGNTLCTYDMS	5	0.33	Al Ca Hu La Mo	heavy	BBPLBAAPBBPBB	32
H1-13-10	11	0.32	1RHHB	kASGGTFssyain	7	0.46	Hu La	heavy	PPADLBDADBPBB	26
H1-13-11	4	0.12	1UM5H	aASerslrSwafa	2	0.13	La Mo	heavy	BPABPDLPPBBBB	35
H1-13-cis9-1	5	62.50	1JTPA	AASGYTIGPYCMG	1	25.00	Ca	heavy	BBBLPDDPpABBB	14
H1-14-1	98	54.14	1ORSB	tVsGySItsdYaWn	38	52.05	Hu Mf Mo Rb	heavy	PBBLBPAAABGBBB	25
H1-15-1	152	76.77	2HWZH	sfSGgSisssgmgwg	57	61.96	CDRLenMismatch Hu Mf Mo	heavy	BBBLBBAAPPLPBBB	24
H1-16-1	1	10.00	1QD0A	AASGRAASGHGHYGMG	1	14.29	CDRLenMismatch	heavy	PBBGPBABGDLBBPBB	-1

L1

Loop	# of Structures	% of Loop Length	Median PDB	Consensus Sequence	# of Unique Seq	% of Unique Seq	Species	Gene	Loop Conformation	Median Angle	Consensus Sequence Logo
L1-10-1	110	60.44	1YQVL	saSssvnymh	45	78.95	CDRLenMismatch Mo	kappa	BBABPBABBB	13
L1-10-2	50	27.47	1AY1L	SASSSVSYih	4	7.02	Mo	kappa	BPABPBBLPB	27
L1-11-1	969	59.19	2D7TL	rASqdignyla	289	52.07	CDRLenMismatch Hu Ma Mo Ra Rb	kappa	BPABPDGDPBB	13
L1-11-2	357	21.81	1ZANL	kASqdisnyla	135	24.32	CDRLenMismatch Ha Hu Ma Mo Ra Rb	kappa	BPABPDLLPBB	14
L1-11-3	107	6.54	1W72M	gGdnigdksah	55	9.91	Hu Ma	lambda	BBPLAAABPBB	22
L1-12-1	132	49.25	35C8L	raSqsvssnyla	60	55.05	CDRLenMismatch Hu Mo	kappa	BBABPBPAADBB	16
L1-12-2	86	32.09	2FX7L	raSqsisnnyla	23	21.10	CDRLenMismatch Hu Mo	kappa	BBABPPPLLPBB	22
L1-12-3	20	7.46	2OTUE	TLssghSnYtia	8	7.34	Hu Mo	lambda	BPPAADAAPPBB	24
L1-13-1	164	71.30	2A9ML	SGssSNIGnnyVn	66	67.35	Bo CDRLenMismatch Hu Ma Sh	lambda	BBBAADAADBPBB	19
L1-13-2	40	17.39	3B5GB	tRSsGniasnYVq	12	12.24	Hu Mo Ra	lambda	BPABGPAAABPBB	14
L1-14-1	94	33.10	1NC2A	gsSsGavTsghyan	18	18.37	Hu La Mo	lambda	BBAAGPPBAAALPB	13
L1-14-2	104	36.62	1DCLB	tGTssDiGgydlVS	47	47.96	Hu La Ma	lambda	PBBAADAAABPDPB	20
L1-15-1	156	83.42	2VL5B	rASeSVdsygnSfmh	79	80.61	CDRLenMismatch Mo	kappa	BPABPDPBLLBBPBB	20
L1-15-2	6	3.21	1I7ZA	RASKSVSsSgnnYMH	6	6.12	Mo	kappa	BPABPDPPADBBPBB	31
L1-16-1	428	93.65	2D03L	rSSqsilhsdGntYLe	144	87.27	CDRLenMismatch Hu Ma Mo Ra	kappa	BBABPAPPAALPBPBB	15
L1-17-1	199	94.76	1QACA	kSSQsllnsgnqkNyLa	81	94.19	Hu La Ma Mo Ra	kappa	BBABPDPPAADLBPPBB	17

H2

Loop	# of Structures	% of Loop Length	Median PDB	Consensus Sequence	# of Unique Seq	% of Unique Seq	Species	Gene	Loop Conformation	Median Angle	Consensus Sequence Logo
H2-8-1	2	7.14	1F2XK	TILGGSTY	1	10.00	CDRLenMismatch	heavy	BBBGAPBB	7
H2-9-1	820	89.42	1KIPB	yissggstn	333	85.82	Al Bo Ca CDRLenMismatch Hu La Mf Mo Ra Rb Sh	heavy	BBPAALPBB	15
H2-9-2	11	1.20	1JGUH	sIrhgfiih	3	0.77	Al Mo	heavy	BBBLLDBBB	19
H2-9-3	31	3.38	1OSPH	vI-sggsty	10	2.58	Al Ca Hu Mo	heavy	BBPPLLPBB	32
H2-10-1	1521	56.63	2BDNH	winpgng-tn	690	51.04	Al Ca CDRLenMismatch Hu La Mf Mo Ra Rb	heavy	BBPAADLPBB	16
H2-10-2	690	25.69	1SEQH	-Issdggsty	345	25.52	Al Ca CDRLenMismatch Ch Ha Hu La Mf Mo Ra	heavy	BBPAALABBB	16
H2-10-3	96	3.57	3DIFD	eilpgsgstn	63	4.66	Al Ca Hu Mo	heavy	BBBPGALPBB	23
H2-10-4	52	1.94	1DSFH	-Ispgggyiy	23	1.70	Al Hu La Mo Ra	heavy	BBPPLLABBB	18
H2-10-5	32	1.19	2P45B	aisggggsiy	15	1.11	Ca Ch Hu La Mf Mo	heavy	BBPAALBLPB	17
H2-10-6	93	3.46	1OAQH	winp-gggtn	60	4.44	Al Ca Hu La Mf Mo	heavy	BBPAPLLPBB	21
H2-10-7	7	0.26	1INDH	nihaGdgdaf	6	0.44	Hu La Mo	heavy	BBPPGPPBBB	31
H2-10-8	5	0.19	1UWEH	gIdPgnGGga	5	0.37	Hu Mo	heavy	BBPAADGGBB	23
H2-10-9	6	0.22	1UWGY	gIdpigggak	6	0.44	Ca Hu Mo	heavy	BBPDALPBPB	28
H2-12-1	198	94.29	2V17H	eIrnkangyate	67	89.33	Al Hu Mf Mo Ra	heavy	BBPPAADLLPBB	13
H2-15-1	2	20.00	1I3UA	TIGRNLVGPSDFYTR	1	33.33	CDRLenMismatch	heavy	BBPDBPABADBPPBB	16

L2

Loop	# of Structures	% of Loop Length	Median PDB	Consensus Sequence	# of Unique Seq	% of Unique Seq	Species	Gene	Loop Conformation	Median Angle	Consensus Sequence Logo
L2-8-1	2978	85.85	1YEJL	y-asnlas	703	71.37	Bo Ha Hu La Ma Mo Ra Rb Sh	kappa lambda	BLLDPPPP	12
L2-8-2	170	4.90	1FL5A	y-anklps	103	10.46	Ch Hu Mo Ra Rb	kappa lambda	BLLDPBPA	18
L2-8-3	19	0.55	1I8KA	SeGNiLRP	6	0.61	Hu Mo	kappa lambda	BPLLPPPP	23
L2-8-4	102	2.94	1ETZA	ygannlps	64	6.50	Hu Ma Mo Rb Sh	kappa lambda	BGDDPPPP	25
L2-8-5	66	1.90	2AEPL	ysannlps	31	3.15	Hu Ma Mo Ra	kappa lambda	DBADPPPP	28
L2-12-1	6	23.08	3BJ91	rYfSdsdkhQGs	5	38.46	Hu Ma	lambda	BBDBAABBBPPP	17
L2-12-2	19	73.08	2OTUC	elkkDGSHntGD	7	53.85	Hu Mo	lambda	BBPAALPBBPPP	19

H3

Loop	# of Structures	% of Loop Length	Median PDB	Consensus Sequence	# of Unique Seq	% of Unique Seq	Species	Gene	Loop Conformation	Median Angle	Consensus Sequence Logo
H3-5-1	11	20.75	1C5CH	ar-gy	7	25.00	Hu La Mo	heavy	BBPLB	23
H3-5-2	15	28.30	1HI6B	argdY	5	17.86	Hu Mo Ra	heavy	BDGAB	21
H3-6-1	26	42.62	1FJ1D	argldy	15	42.86	Ca Mo	heavy	BPGDDB	29
H3-7-1	58	54.21	1XGQB	anwdgdy	16	32.65	Hu Mo Ra	heavy	BPAALAB	12
H3-7-2	8	7.48	1V7MH	askgfiY	6	12.24	Mo	heavy	BBLLLAB	17
H3-7-3	11	10.28	1GAFH	asygfiy	7	14.29	Mo	heavy	BPPLLAB	12
H3-7-cis4-1	2	66.67	1E4XH	ARSPSDY	1	50.00	Mo	heavy	BBBbLPB	4
H3-8-1	1	1.89	1F3DK	ANDYDGVY	1	3.03	Mo	heavy	BBDPLGBB	-1
H3-8-2	20	37.74	2EH7H	aRgr-fdy	12	36.36	Hu Mo	heavy	BPGAALAB	19
H3-9-1	27	16.07	1AXTH	arydydgay	17	14.66	Ha Hu Mo	heavy	BBBBADBBB	28
H3-9-2	58	34.52	1ZEAH	argg-gfdy	36	31.03	Hu Mo Ra Rb	heavy	BPBDABPAB	31

L3

Loop	# of Structures	% of Loop Length	Median PDB	Consensus Sequence	# of Unique Seq	% of Unique Seq	Species	Gene	Loop Conformation	Median Angle	Consensus Sequence Logo
L3-7-1	4	80.00	1DFBL	hQrnSYs	3	75.00	Hu Mo	kappa	BPDADLP	23
L3-8-1	119	48.97	3CMOL	lQsynlwT	47	38.52	Hu Mo Ra	kappa	BPDABGBB	12
L3-8-2	17	7.00	1KEGL	qqslsspt	13	10.66	Hu Mo	kappa lambda	BPDPGPPB	31
L3-8-cis6-1	4	57.14	1E6OL	QQhdYPfT	2	40.00	Mo	kappa	BPABPaLP	9
L3-9-1	131	30.90	1F4XL	alwdnghwt	43	20.87	Ch Hu Ma Mo Ra	kappa lambda	BBBBLLBPB	31
L3-9-2	134	31.60	1KCSL	qQsyssppT	78	37.86	Hu Mo	kappa	BBDABAPPB	23
L3-9-cis6-1	3	37.50	2FBJL	QQWTYPLIT	2	33.33	Mo	kappa	BBBBPdBBB	31
L3-9-cis7-1	1847	95.21	1J1PL	qqy-s-PlT	667	91.62	Ha Hu La Ma Mo Ra	kappa	BBDABPpPB	14
L3-9-cis7-2	36	1.86	1G7IA	QhfwgtPrT	23	3.16	Hu Mo	kappa	BBDPGBpPB	22
L3-9-cis7-3	30	1.55	1L7IL	qqsysypft	17	2.34	Hu Mo	kappa	BPDABPaLP	20
L3-10-1	52	22.13	3B5GB	qsydss-tvv	26	24.07	Hu Ma	kappa lambda	BBPBAALBBB	23
L3-10-cis7,8-1	27	93.10	1JGUL	qQsshwPPiT	15	88.24	Hu Mo	kappa	BBDABBppPB	12
L3-10-cis8-1	1	4.55	1I7ZC	LYSREFPPWT	1	7.69	Mo	kappa	BBBBABPpBB	-1
L3-11-1	157	61.33	2A9MM	aawDdslngwv	86	59.31	Ch Hu Ma Mo	kappa lambda	BBPBAAALBPB	19
L3-11-cis7-1	27	65.85	2NXYC	QQYNNWPPRYT	2	18.18	Hu	kappa lambda	BBBDPBpPBPB	15
L3-12-1	8	5.97	3C2AL	asfDSgldadlV	5	11.90	Hu	lambda	BBPPAPAALBPB	23
L3-13-1	5	17.24	2OTUG	GVGDTIKEQFVYV	2	14.29	Hu Mo	lambda	BBBBBBGAPPBBB	23

Site developed by the Antibody Team at the lab of Roland Dunbrack. Last updated on November 1, 2019

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