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Glossary
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CDR
CDR refers to the Complementary determining regions of antibodies where these proteins complement an antigen's shape.
CDRs determine the proteins avidity and specificity for specific antigens.
The CDRs are the most variable part of the antibody molecule, and contribute to the diversity of these molecules,
allowing the antibody and the T-cell receptor to recognize a vast repertoire of antigens.
The sketch and text are from wikipedia
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CDR clusters
There are 8 CDR loops: H1, H2, H3, H4 of the heavy chain variable domain (VH),
L1, L2, L3, L4 of the light chain variable domain (VL) of various lengths.
We now have 52 clusters, of which 16 are new and 36 are the same as defined in North et al.
The total numbers of clusters for each CDR are as follows: H1 (8); H2 (8); H3 (13); H4 (3); L1 (17); L2 (3); L3 (17); L4 (4).
L1-11 means L1 length 11. L1-11-1 is the largest L1-11 cluster.
We have 73 clusters across the 8 CDRs.
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Germline
IMGT (Im Muno Gene Tics) germline identifiers
are of the form IGltf-g*aa (e.g. IGHV4-1*01), where l denotes the locus: heavy (H), kappa (K) and lambda (L).
t denotes the type of gene segment: V, D, J or C. f is the gene family, a number.
g is the individual gene, a number, and aa means the allele.
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