FCCC    Clusters of Antibody CDR Loop Conformations     Dunbrack Lab
 

Summary info for CDR clusters

H1

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
H1-10-18100.001KXQFaaSeytyrmG5100.00CDRLenMismatchheavyPBABPBABBB14
H1-12-1337.501GHFHKagfnfkDvgMn240.00CDRLenMismatchheavyPBABPAAABBBB31
H1-13-1193178.301RURHaaSGfsfsdywih81572.90Al Ca CDRLenMismatch Ha Hu La Mf Mo Ra Rbheavy NAPBBLBPAAABPBB16
H1-13-2401.621UWGYaasgfnikdyaig343.04Al Hu Mo Raheavy NABBADBPAAABPBB27
H1-13-3592.391U0QAaaSGrtfsnyaig433.85Al Ca Hu La Mf Moheavy NAPBPGDDAAABPBB31
H1-13-4883.571IC4HaasGgsfsgygis353.13Al Hu Mf Moheavy NABPBLBBAPLBPBB24
H1-13-5230.931MVFAaASGnifsinamg201.79Al Ca Laheavy NABPBGPAAAPABBB21
H1-13-6220.892P45BaASGstfssivmg110.98Al Ca HuheavyBBBLPABPPABBB25
H1-13-7190.771DQDHkasGdsftsgfmn131.16Hu Moheavy NAPBBLBPAABGBBB21
H1-13-8421.701HCVAaASGaTgssddig40.36Al Hu La MoheavyPBBGLBGAABBBB38
H1-13-960.241KXVDAASGNTLCTYDMS50.45Al Ca Hu La Moheavy NABBPLBAAPBBPBB32
H1-13-1060.241RHHBKASGGTFdmYafh40.36HuheavyPPAALBDGAPBBB21
H1-13-1140.161UM5HaASerslrSwafa20.18Al MoheavyBPABPDLPPBBBB35
H1-13-cis9-1562.501JTPAAASGYTIGPYCMG125.00CaheavyBBBLPDDPpABBB14
H1-14-18460.871ORSBtVsGYSItsdYaWn3057.69Hu Mo Rbheavy NAPBBLBPAAABGBBB23
H1-15-112885.912HWZHsfSGfSlsssgmgwg4171.93CDRLenMismatch Hu Mf Moheavy NABBBLBBAAPPLPBBB22
H1-16-1120.001QD0AAASGRAASGHGHYGMG125.00CDRLenMismatchheavyPBBGPBABGDLBBPBB-1

L1

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
L1-10-18965.441YQVLsasssvnymh3882.61CDRLenMismatch MokappaBPABPBABBB13
L1-10-24130.151AY1LSASSSVSYih48.70MokappaBPABPBBLPB28
L1-11-174060.811OP3LrASqdignyla22252.98CDRLenMismatch Hu Ma Mo Ra Rbkappa NABPABPDGDPBB13
L1-11-229223.991ZANLkaSqdisnyla10825.78Ha Hu Ma Mo Ra Rbkappa NABPABPDLLPBB14
L1-11-3746.081W72MgGdnigdksah399.31Hu Malambda NABBPLAAABPBB22
L1-12-19347.4535C8LsaSqsvssnyla3952.70CDRLenMismatch Hu Mokappa NABBABPBPAADBB16
L1-12-27136.222FX7LqaSqsisnnklA1824.32CDRLenMismatch Hu Mokappa NABBABPPPLLPBB21
L1-12-3147.142OTUETLssqHStYtIe56.76Hu Molambda NABPPAADAAPPBB21
L1-13-111072.852A9MLSGssSNIGnnyVn5069.44CDRLenMismatch Hu Malambda NABBBAADAADBPBB18
L1-13-22415.893B5GBtrSsGniannYVq912.50Hu RalambdaBPABGPAAABPBB14
L1-14-17235.291NC2AgsSsGavTssnyan1522.06Hu La MolambdaBBAAGPPBAAALPB13
L1-14-27737.751DCLBtGTssDiGgydyVS3247.06Hu La Malambda NABBBAADAAABABBB20
L1-15-112088.892VL5BrASesVdssGnSfmh6181.33Mokappa NABPABPDPBLLBBPBB21
L1-15-264.441I7ZARASKSVSsSgnnYMH68.00MokappaBPABPDPPADBBPBB31
L1-16-135394.132D03LrSSqsilhsdGntyLe11988.15CDRLenMismatch Hu Mo Rakappa NABBABPAPPAALPBPBB14
L1-17-115494.481QACAKSSQsllnsgnqkNyLa6394.03Hu La Mokappa NABBABPDPPAADLBPPBB15

H2

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
H2-8-1210.001F2XKTILGGSTY114.29CDRLenMismatchheavyBBBGAPBB7
H2-9-161491.921KIPByisydgstn23987.23Al Ca CDRLenMismatch Hu La Mf Mo Ra Rbheavy NABBPAALPBB14
H2-9-291.351JGUHsIrngfiih20.73MoheavyBBBLLDBBB19
H2-9-3142.101OSPHvIysggsty93.28Ca Hu Moheavy NABBPPLLPBB28
H2-10-1111458.052BDNHwinpgng-tn52453.14Al Ca CDRLenMismatch Hu La Mf Mo Ra Rbheavy NABBPAADLPBB16
H2-10-247324.651SEQH-Issdgg-ty24224.54Al Ca CDRLenMismatch Ha Hu La Mo Raheavy NABBPAALABBB16
H2-10-3723.753DIFDeilpgngstn515.17Al Ca CDRLenMismatch Hu Mo Rbheavy NABBBPGALPBB23
H2-10-4351.821DSFHgIspgggyid161.62CDRLenMismatch Hu Moheavy NABBPPLLABBB19
H2-10-5241.252P45Baingggggiy90.91Ca CDRLenMismatch Hu Mf Moheavy NABBPAALBLPB15
H2-10-6753.911OAQHwinpsgg-tn474.77Al Ca CDRLenMismatch Hu Mf Moheavy NABBPAPLLPBB22
H2-10-760.311INDHnihaGdgdaf50.51Al Hu MoheavyBBPPGPPBBB30
H2-10-840.211UWEHgIdPgnGGga40.41Hu MoheavyBBPAADGGBB20
H2-10-960.311UWGYgIdpigggak60.61Ca Hu MoheavyBBPDALPBPB28
H2-12-116293.642V17HeIrnkangyate5388.33Ha Hu Mo Raheavy NABBPPAADLLPBB13
H2-15-1222.221I3UATIGRNLVGPSDFYTR133.33CDRLenMismatchheavyBBPDBPABADBPPBB16

L2

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
L2-8-1227487.361F8TLy-asnlas54072.68Ha Hu La Ma Mo Ra Rbkappa lambda NABLLDPPPP12
L2-8-21204.611FL5Aydanklps7610.23Hu Mo Rakappa lambda NABLLDPBPA17
L2-8-3160.611I8KASeGNiLRP50.67Hu Mokappa lambdaBPLLPPPP23
L2-8-4702.691ETZAygannlps435.79Hu Ma Mo Rbkappa lambda NABGDDPPPP25
L2-8-5311.192AEPLy-asnrps212.83Hu Ma Mokappa lambda NADBADPPPP30
L2-12-1316.673BJ91rYfSdSdkhQGp333.33Hu MalambdaBBDBAABBBPPP8
L2-12-21477.782OTUCelkkDGSHntGD555.56Hu Molambda NABBPAALPBBPPP20

H3

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
H3-5-11024.391C5CHar-gy631.58Al La MoheavyBBPLB20
H3-5-21331.711HI6BasgDY315.79Hu Mo RaheavyBDGAB19
H3-6-12543.101FJ1Dargldy1545.45Hu MoheavyBPGDDB28
H3-7-14954.441XGQBanwdgdy1330.23Mo RaheavyBPAALAB11
H3-7-2910.001KTRHaskggaY716.28MoheavyBBLLLAB17
H3-7-3910.001GAFHasygfiy613.95MoheavyBPPLLAB12
H3-7-cis4-1266.671E4XHARSPSDY150.00MoheavyBBBbLPB4
H3-8-112.861F3DKANDYDGVY14.35MoheavyBBDPLGBB-1
H3-8-21440.002EH7HaRgldfay939.13Hu Moheavy NABPGADLAB21
H3-9-12116.281AXTHarydydgay1314.61Ha Moheavy NABBBBADBBB29
H3-9-24837.211ZEAHargg-gfdy3134.83Hu Mo Ra RbheavyBPBDABPAB30

L3

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
L3-7-13100.001DFBLhQrnSYs2100.00Hu MokappaBPDADLP20
L3-8-18853.013CMOLkQsnnlrT3139.24Hu Mo Rakappa NABPDABGBB12
L3-8-2127.231KEGLfhggslpT810.13Hu MokappaBBABGBPB31
L3-8-cis6-1457.141E6OLQQhdYPfT240.00MokappaBPABPaLP9
L3-9-19030.101F4XLalwdnnhlv3020.41Hu Ma Mokappa lambda NABBPBLLBPB31
L3-9-210535.121KCSLqQssslppT6040.82Hu Mokappa NABBDABAPPB23
L3-9-cis6-1120.002FBJLQQWTYPLIT125.00MokappaBBBBPdBBB-1
L3-9-cis7-1146995.391J1PLqqgss-PlT52691.32Ha Hu La Ma Mo Ra Rbkappa NABBDABPpPB14
L3-9-cis7-2352.271G7IAQhfwgtPrT223.82Hu Mokappa NABBDPGBpPB21
L3-9-cis7-3171.101L7ILqqsysyPlT132.26Hu MokappaBPDABPaLP19
L3-10-14426.513B5GBqsydssstvv2026.32Hu Malambda NABBPBAALBBB23
L3-10-cis7,8-121100.001JGULqQsghwPPiT11100.00Hu Mokappa NABBDABBppPB12
L3-10-cis8-115.561I7ZCLYSREFPPWT19.09MokappaBBBBABPpBB-1
L3-11-110864.292A9MMaawDdsldgwv6361.17Hu Ma Mokappa lambda NABBPBAAALBPB19
L3-11-cis7-12571.432NXYCQQYNNWPPRYT225.00Hukappa lambdaBBBDPBpPBPB11
L3-12-167.893C2ALATWDSGLSADWV311.54HulambdaBBBPAPAALPPB21
L3-13-1419.052OTUGGVGDTIKEQFVYV112.50MolambdaBBBBBBGAPPBBB22