FCCC    Clusters of Antibody CDR Loop Conformations     Dunbrack Lab
 

Summary info for CDR clusters

H1

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
H1-10-18100.001KXQFaaSeytyrmG5100.00CDRLenMismatchheavyPBABPBABBB14
H1-12-1337.501GHFHKagfnfkDvgMn240.00CDRLenMismatchheavyPBABPAAABBBB31
H1-13-1207778.701RURHaaSGfsfsdywih87072.93Al Ca CDRLenMismatch Ha Hu La Mf Mo Ra Rbheavy NAPBBLBPAAABPBB16
H1-13-2431.631UWGYaasefnikdyaig373.10Al Hu Mo Raheavy NABBADBPAAABPBB26
H1-13-3612.311U0QAaaSgrtfsnyaig443.69Al Ca Hu La Mf Moheavy NAPBPGDDAAABPBB31
H1-13-4873.301IC4HaasGgsfsgygis342.85Al Hu Mf Moheavy NABPBLBBAPLBPBB24
H1-13-5301.141MVFAaASGsifsinamg262.18Al Ca Hu La Moheavy NAPPBGPAAAPDBBB21
H1-13-6230.872P45BaASGstfssivmg121.01Al Ca Huheavy NABBBLPABPPABBB25
H1-13-7200.761DQDHkasGdsftsgfmn141.17Hu La Moheavy NAPBBLBPAABGBBB22
H1-13-8451.711HCVAaASGaTgssddig40.34Al Hu La Moheavy NAPBBGLBGAABBBB38
H1-13-960.231KXVDAASGNTLCTYDMS50.42Al Ca Hu La Moheavy NABBPLBAAPBBPBB32
H1-13-1060.231RHHBKASGGTFdmYafh40.34HuheavyPPAALBDGAPBBB21
H1-13-1140.151UM5HaASerslrSwafa20.17Al MoheavyBPABPDLPPBBBB35
H1-13-cis9-1562.501JTPAAASGYTIGPYCMG125.00CaheavyBBBLPDDPpABBB14
H1-14-18658.501ORSBtVsGYSItsdYaWh3255.17Hu Mo Rbheavy NAPBBLBPAAABGBBB24
H1-15-113283.542HWZHsfSGfSlsssgmgwg4369.35CDRLenMismatch Hu Mf Moheavy NABBBLBBAAPPLPBBB23
H1-16-1111.111QD0AAASGRAASGHGHYGMG116.67CDRLenMismatchheavyPBBGPBABGDLBBPBB-1

L1

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
L1-10-19565.971YQVLsasssvnymh3979.59CDRLenMismatch Mokappa NABPABPBABBB13
L1-10-24128.471AY1LSASSSVSYih48.16MokappaBPABPBBLPB28
L1-11-179261.301OP3LrASqdignyla23553.17CDRLenMismatch Hu Ma Mo Ra Rbkappa NABPABPDGDPBB13
L1-11-230323.451ZANLkASqdisnyla11325.57CDRLenMismatch Ha Hu Ma Mo Ra Rbkappa NABPABPDLLPBB14
L1-11-3796.111W72MgGdnigdksah429.50Hu Malambda NABBPLAAABPBB21
L1-12-110148.1035C8LsaSqsvssnyla4553.57CDRLenMismatch Hu Mokappa NABBABPBPAADBB16
L1-12-27435.242FX7LraSqsvssnylA2023.81CDRLenMismatch Hu Mokappa NABBABPPPLLPBB22
L1-12-3146.672OTUETLssqHStYtIe55.95Hu Molambda NABPPAADAAPPBB21
L1-13-111472.612A9MLSGssSNIGnnyVn5369.74CDRLenMismatch Hu Malambda NABBBAADAADBPBB18
L1-13-22515.923B5GBtrSsGniannYVq911.84Hu Mo Ralambda NABPABGPAAABPBB14
L1-14-17633.041NC2AgsSsGavTssnyan1518.52Hu La Molambda NABBAAGPPBAAALPB13
L1-14-29240.001DCLBtGTssDiGgydyVS4150.62Hu La Malambda NABBBAADAADBPDPB19
L1-15-113284.622VL5BrASesVdsygnSfmh6681.48CDRLenMismatch Mokappa NABPABPDPBLLBPPBB21
L1-15-263.851I7ZARASKSVSsSgnnYMH67.41MokappaBPABPDPPADBBPBB31
L1-16-136194.012D03LrSSqsilhsdGntyLe12488.57CDRLenMismatch Hu Mo Rakappa NABBABPAPPAALPBPBB15
L1-17-116194.711QACAKSSQsllnsgnqkNyLa6694.29Hu La Mo Rakappa NABBABPDPPAADLBPPBB15

H2

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
H2-8-1210.001F2XKTILGGSTY114.29CDRLenMismatchheavyBBBGAPBB7
H2-9-165191.951KIPByisydgstn25787.71Al Ca CDRLenMismatch Hu La Mf Mo Ra Rbheavy NABBPAALPBB14
H2-9-291.271JGUHsIrngfiih20.68MoheavyBBBLLDBBB19
H2-9-3162.261OSPHvIysggsty93.07Ca Hu Moheavy NABBPPLLPBB27
H2-10-1119057.632BDNHwinpgng-tn55752.20Al Ca CDRLenMismatch Hu La Mf Mo Ra Rbheavy NABBPAADLPBB16
H2-10-251624.991SEQH-Issdggsty26825.12Al Ca CDRLenMismatch Ha Hu La Mo Raheavy NABBPAALABBB16
H2-10-3793.833DIFDeilpgngstn545.06Al Ca CDRLenMismatch Hu Moheavy NABBBPGALPBB22
H2-10-4361.741DSFH-Ispgggyiy171.59Al CDRLenMismatch Hu Moheavy NABBPPLLABBB18
H2-10-5261.262P45Baingggggiy111.03Ca CDRLenMismatch Hu Mf Moheavy NABBPAALBLPB16
H2-10-6793.831OAQHwinpsgg-tn514.78Al Ca CDRLenMismatch Hu Mf Moheavy NABBPAPLLPBB22
H2-10-770.341INDHnihaGdgdaf60.56Al Hu Moheavy NABBPPGPPBBB31
H2-10-840.191UWEHgIdPgnGGga40.37Hu MoheavyBBPAADGGBB20
H2-10-960.291UWGYgIdpigggak60.56Ca Hu MoheavyBBPDALPBPB28
H2-12-117093.412V17HeIrnkangyate5587.30Ha Hu Mo Raheavy NABBPPAADLLPBB13
H2-15-1220.001I3UATIGRNLVGPSDFYTR133.33CDRLenMismatchheavyBBPDBPABADBPPBB16

L2

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
L2-8-1241487.091F8TLy-asnlas57372.72Ha Hu La Ma Mo Ra Rbkappa lambda NABLLDPPPP12
L2-8-21254.511FL5Aydanklps7910.03Hu Mo Rakappa lambda NABLLDPBPA17
L2-8-3160.581I8KASeGNiLRP50.63Hu Mokappa lambdaBPLLPPPP23
L2-8-4802.891ETZAygannlps496.22Hu Ma Mo Rbkappa lambda NABGDDPPPP25
L2-8-5311.122AEPLy-asnrps222.79Hu Ma Mokappa lambda NADBADPPPP30
L2-12-1316.673BJ91rYfSdSdkhQGp333.33Hu MalambdaBBDBAABBBPPP8
L2-12-21477.782OTUCelkkDGSHntGD555.56Hu Molambda NABBPAALPBBPPP20

H3

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
H3-5-11023.261C5CHar-gy628.57Al La MoheavyBBPLB20
H3-5-21330.231HI6BasgDY314.29Hu Mo Raheavy NABDGAB19
H3-6-12542.371FJ1Dargldy1544.12Hu MoheavyBPGDDB28
H3-7-14951.581XGQBanwdgdy1329.55Mo RaheavyBPAALAB11
H3-7-288.42-NA613.64Moheavy 18
H3-7-399.471GAFHasygfiy613.64MoheavyBPPLLAB12
H3-7-cis4-1266.671E4XHARSPSDY150.00MoheavyBBBbLPB4
H3-8-112.381F3DKANDYDGVY13.85MoheavyBBDPLGBB-1
H3-8-21842.862EH7HaRgr-fdy1038.46Hu Moheavy NABPGAALAB20
H3-9-12316.671AXTHarydydgay1414.58Ha Moheavy NABBBBADBBB28
H3-9-24834.781ZEAHargg-gfdy3132.29Hu Mo Ra RbheavyBPBDABPAB30

L3

Loop# of Structures% of Loop LengthMedian PDBConsensus Sequence# of Unique Seq% of Unique SeqSpeciesGeneLoop ConformationMedian AngleConsensus Sequence Logo
L3-7-14100.001DFBLhQrnSYs3100.00Hu Mokappa NABPDADLP23
L3-8-19152.603CMOLkQyynlrT3440.48Hu Mo Rakappa NABBDABGBB12
L3-8-2126.941KEGLfhggslpT89.52Hu MokappaBBABGBPB31
L3-8-cis6-1457.141E6OLQQhdYPfT240.00MokappaBPABPaLP9
L3-9-19931.431F4XLalwdnnhlv3120.13Hu Ma Mokappa lambda NABBBBLLBPB31
L3-9-210733.971KCSLqQssslppT6240.26Hu Mokappa NABBDABAPPB23
L3-9-cis6-1120.002FBJLQQWTYPLIT125.00MokappaBBBBPdBBB-1
L3-9-cis7-1155494.811J1PLqqgss-PlT56191.37Ha Hu La Ma Mo Ra Rbkappa NABBDABPpPB14
L3-9-cis7-2362.201G7IAQhfwgtPrT233.75Hu Mokappa NABBDPGBpPB22
L3-9-cis7-3271.651L7ILqqsysyPlT142.28Hu Mokappa NABPDABPaLP20
L3-10-14625.563B5GBqswdssstvv2226.19Hu Malambda NABBPBAALBBB23
L3-10-cis7,8-122100.001JGULqQsthwPplT12100.00Hu Mokappa NABBDABBppPB12
L3-10-cis8-115.561I7ZCLYSREFPPWT19.09MokappaBBBBABPpBB-1
L3-11-111462.302A9MMaawDdsldgwv6860.18Hu Ma Mokappa lambda NABBPBAAALBPB19
L3-11-cis7-12672.222NXYCQQYNNWPPRYT225.00Hukappa lambda NABBBDPBpPBPB14
L3-12-189.763C2ALasfDSgldadlV516.67Hulambda NABBPPAPAALBPB23
L3-13-1419.052OTUGGVGDTIKEQFVYV112.50MolambdaBBBBBBGAPPBBB22