FCCC    Clusters of Antibody CDR Loop Conformations     Dunbrack Lab


  • CDR

    CDR refers to the Complementary determining regions of antibodies where these proteins complement an antigen's shape. CDRs determine the proteins avidity and specificity for specific antigens. The CDRs are the most variable part of the antibody molecule , and contribute to the diversity of these molecules, allowing the antibody and the T-cell receptor to recognize a vast repertoire of antigens.


    The sketch and text are from wikipedia, please refers wikipedia for more details.

  • CDR clusters

    There are 6 CDR loops: H1, H2, H3 of the heavy chain variable domain (VH), L1, L2, L3 of the light chain variable domain (VL) of various lengths. There are 64 CDR-length combinations in our databases, in which there are 21 CDR1-length combinations, 9 CDR2-length combinations and 34 CDR3-length combinations. CDR H3 contains 25 different lengths.

    L1-11 means L1 length 11.

    We have 72 clusters for the non-H3 CDRs. The details about the clusters please refer to Benjamin North paper.

  • Germline

    IMGT (Im Muno Gene Tics) germline identifiers are of the form IGltf-g*aa (e.g. IGHV4-1*01), where l denotes the locus: heavy (H), kappa (K) and lambda (L). t denotes the type of gene segment: V, D, J or C. f is he gene family, a number. g is the individual gene, a number, and aa means the allele.