| 2Fe-2S_thioredx | PF01257 | Thioredoxin-like [2Fe-2S] ferredoxin | 1 | 1 |
| 2OG-FeII_Oxy | PF03171 | 2OG-Fe(II) oxygenase superfamily | 28 | 16 |
| 2OG-FeII_Oxy_2 | PF13532 | 2OG-Fe(II) oxygenase superfamily | 45 | 45 |
| 2OG-FeII_Oxy_3 | PF13640 | 2OG-Fe(II) oxygenase superfamily | 38 | 37 |
| 2OG-FeII_Oxy_4 | PF13661 | 2OG-Fe(II) oxygenase superfamily | 5 | 5 |
| 4PPT_N | PF17837 | 4'-phosphopantetheinyl transferase N-terminal domain | 7 | 7 |
| 5_3_exonuc | PF01367 | 5'-3' exonuclease, C-terminal SAM fold | 6 | 5 |
| 5_3_exonuc_N | PF02739 | 5'-3' exonuclease, N-terminal resolvase-like domain | 6 | 6 |
| 5_nucleotid | PF05761 | 5' nucleotidase family | 1 | 1 |
| 5_nucleotid_C | PF02872 | 5'-nucleotidase, C-terminal domain | 12 | 1 |
| AAA_18 | PF13238 | AAA domain | 1 | 1 |
| AAA_26 | PF13500 | AAA domain | 1 | 1 |
| AAA_28 | PF13521 | AAA domain | 1 | 1 |
| AAA_33 | PF13671 | AAA domain | 1 | 1 |
| AA_kinase | PF00696 | Amino acid kinase family | 1 | 1 |
| ABC_tran | PF00005 | ABC transporter | 1 | 1 |
| ACD | PF16671 | Actin cross-linking domain | 3 | 3 |
| ACPS | PF01648 | 4'-phosphopantetheinyl transferase superfamily | 7 | 7 |
| ACP_syn_III | PF08545 | 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III | 6 | 1 |
| ACP_syn_III_C | PF08541 | 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal | 6 | 1 |
| ADH_N | PF08240 | Alcohol dehydrogenase GroES-like domain | 1 | 1 |
| ADK | PF00406 | Adenylate kinase | 1 | 1 |
| ADP_ribosyl_GH | PF03747 | ADP-ribosylglycohydrolase | 4 | 4 |
| AIRS_C | PF02769 | AIR synthase related protein, C-terminal domain | 2 | 2 |
| AMP_N | PF05195 | Aminopeptidase P, N-terminal domain | 48 | 5 |
| AP_endonuc_2 | PF01261 | Xylose isomerase-like TIM barrel | 127 | 127 |
| ARMT1-like_dom | PF01937 | Damage-control phosphatase ARMT1-like domain | 1 | 1 |
| ATP-grasp_2 | PF08442 | ATP-grasp domain | 1 | 1 |
| Abhydrolase_1 | PF00561 | alpha/beta hydrolase fold | 1 | 1 |
| Abhydrolase_6 | PF12697 | Alpha/beta hydrolase family | 4 | 4 |
| AceK | PF06315 | Isocitrate dehydrogenase kinase/phosphatase (AceK) | 1 | 1 |
| AcetDehyd-dimer | PF09290 | Prokaryotic acetaldehyde dehydrogenase, dimerisation | 2 | 1 |
| Acetate_kinase | PF00871 | Acetokinase family | 1 | 1 |
| Acetyltransf_3 | PF13302 | Acetyltransferase (GNAT) domain | 1 | 1 |
| Adenine_deam_C | PF13382 | Adenine deaminase C-terminal domain | 1 | 1 |
| AdoMet_Synthase | PF01941 | S-adenosylmethionine synthetase (AdoMet synthetase) | 1 | 1 |
| Ala_racemase_N | PF01168 | Alanine racemase, N-terminal domain | 1 | 1 |
| Aldolase_II | PF00596 | Class II Aldolase and Adducin N-terminal domain | 3 | 3 |
| Alpha-amylase | PF00128 | Alpha amylase, catalytic domain | 3 | 3 |
| Amidohydro_1 | PF01979 | Amidohydrolase family | 5 | 5 |
| Amidohydro_2 | PF04909 | Amidohydrolase | 13 | 13 |
| Aminoglyc_resit | PF10706 | Aminoglycoside-2''-adenylyltransferase | 3 | 3 |
| AnmK | PF03702 | Anhydro-N-acetylmuramic acid kinase | 1 | 1 |
| Anp1 | PF03452 | Anp1 | 1 | 1 |
| ApbE | PF02424 | ApbE family | 1 | 1 |
| Arabinose_Iso_C | PF11762 | L-arabinose isomerase C-terminal domain | 8 | 8 |
| Arabinose_Isome | PF02610 | L-arabinose isomerase | 10 | 10 |
| ArenaCapSnatch | PF17296 | Arenavirus cap snatching domain | 13 | 2 |
| Arena_RNA_pol | PF06317 | Arenavirus RNA polymerase | 13 | 12 |
| Arena_ncap_C | PF17290 | Arenavirus nucleocapsid C-terminal domain | 9 | 9 |
| Arena_nucleocap | PF00843 | Arenavirus nucleocapsid N-terminal domain | 2 | 1 |
| Arginase | PF00491 | Arginase family | 154 | 151 |
| Asp_Arg_Hydrox | PF05118 | Aspartyl/Asparaginyl beta-hydroxylase | 22 | 22 |
| AstE_AspA | PF04952 | Succinylglutamate desuccinylase / Aspartoacylase family | 2 | 2 |
| AurF | PF11583 | P-aminobenzoate N-oxygenase AurF | 1 | 1 |
| B5 | PF03484 | tRNA synthetase B5 domain | 3 | 3 |
| BAH | PF01426 | BAH domain | 1 | 1 |
| BNR_2 | PF13088 | BNR repeat-like domain | 2 | 2 |
| BPL_LplA_LipB | PF03099 | Biotin/lipoate A/B protein ligase family | 1 | 1 |
| Bac_DNA_binding | PF00216 | Bacterial DNA-binding protein | 3 | 3 |
| Bact_lectin | PF18483 | Bacterial lectin | 2 | 2 |
| BamHI | PF02923 | Restriction endonuclease BamHI | 1 | 1 |
| Beta_propel | PF09826 | Beta propeller domain | 1 | 1 |
| Bgal_small_N | PF02929 | Beta galactosidase small chain | 1 | 1 |
| Birna_RdRp | PF04197 | Birnavirus RNA dependent RNA polymerase (VP1) | 1 | 1 |
| BpuSI_N | PF15516 | BpuSI N-terminal domain | 1 | 1 |
| Bse634I | PF07832 | Cfr10I/Bse634I restriction endonuclease | 1 | 1 |
| C1-set | PF07654 | Immunoglobulin C1-set domain | 34 | 3 |
| C2 | PF00168 | C2 domain | 2 | 1 |
| CAF1 | PF04857 | CAF1 family ribonuclease | 2 | 2 |
| CARDB | PF07705 | CARDB | 1 | 1 |
| CBM_4_9 | PF02018 | Carbohydrate binding domain | 6 | 1 |
| CBS | PF00571 | CBS domain | 2 | 1 |
| CDC37_N | PF03234 | Cdc37 N terminal kinase binding | 3 | 1 |
| CDP-OH_P_transf | PF01066 | CDP-alcohol phosphatidyltransferase | 1 | 1 |
| CLP1_P | PF16575 | mRNA cleavage and polyadenylation factor CLP1 P-loop | 1 | 1 |
| COX1 | PF00115 | Cytochrome C and Quinol oxidase polypeptide I | 8 | 8 |
| COX2 | PF00116 | Cytochrome C oxidase subunit II, periplasmic domain | 8 | 8 |
| CPSase_L_D2 | PF02786 | Carbamoyl-phosphate synthase L chain, ATP binding domain | 31 | 10 |
| CRISPR_Cas2 | PF09827 | CRISPR associated protein Cas2 | 7 | 3 |
| CTP_transf_like | PF01467 | Cytidylyltransferase-like | 2 | 1 |
| CYTH | PF01928 | CYTH domain | 7 | 7 |
| Cadherin | PF00028 | Cadherin domain | 1 | 1 |
| Carb_anhydrase | PF00194 | Eukaryotic-type carbonic anhydrase | 1 | 1 |
| Carbam_trans_C | PF16861 | Carbamoyltransferase C-terminus | 2 | 2 |
| Cas9_PI | PF16595 | PAM-interacting domain of CRISPR-associated endonuclease Cas9 | 1 | 1 |
| Cas9_REC | PF16592 | REC lobe of CRISPR-associated endonuclease Cas9 | 1 | 1 |
| Cas_Cas1 | PF01867 | CRISPR associated protein Cas1 | 8 | 4 |
| Cas_Cas4 | PF01930 | Domain of unknown function DUF83 | 8 | 8 |
| Cas_csx3 | PF09620 | CRISPR-associated protein (Cas_csx3) | 1 | 1 |
| Cation_ATPase_C | PF00689 | Cation transporting ATPase, C-terminus | 3 | 1 |
| Cation_ATPase_N | PF00690 | Cation transporter/ATPase, N-terminus | 3 | 2 |
| Cellulase | PF00150 | Cellulase (glycosyl hydrolase family 5) | 1 | 1 |
| Cellulose_synt | PF03552 | Cellulose synthase | 2 | 2 |
| Chitin_synth_1 | PF01644 | Chitin synthase | 2 | 2 |
| Chol_subst-bind | PF09129 | Cholesterol oxidase, substrate-binding | 2 | 2 |
| CoV_Methyltr_2 | PF06460 | Coronavirus 2'-O-methyltransferase | 1 | 1 |
| CoV_NSP9 | PF08710 | Coronavirus replicase NSP9 | 2 | 1 |
| CoV_RPol_N | PF06478 | Coronavirus RNA-dependent RNA polymerase, N-terminal | 2 | 2 |
| Complex1_30kDa | PF00329 | Respiratory-chain NADH dehydrogenase, 30 Kd subunit | 1 | 1 |
| Complex1_49kDa | PF00346 | Respiratory-chain NADH dehydrogenase, 49 Kd subunit | 1 | 1 |
| Copine | PF07002 | Copine | 1 | 1 |
| CorC_HlyC | PF03471 | Transporter associated domain | 1 | 1 |
| CpsB_CapC | PF19567 | Capsular polysaccharide synthesis, CpsB/CapC | 3 | 3 |
| Creatininase | PF02633 | Creatinine amidohydrolase | 8 | 8 |
| Csm1_B | PF18211 | Csm1 subunit domain B | 6 | 1 |
| Cu_amine_oxid | PF01179 | Copper amine oxidase, enzyme domain | 2 | 2 |
| Cu_amine_oxidN2 | PF02727 | Copper amine oxidase, N2 domain | 2 | 2 |
| Cupin_1 | PF00190 | Cupin | 18 | 18 |
| Cupin_2 | PF07883 | Cupin domain | 14 | 14 |
| Cupin_4 | PF08007 | Cupin superfamily protein | 10 | 10 |
| Cupin_8 | PF13621 | Cupin-like domain | 24 | 24 |
| Cyclase | PF04199 | Putative cyclase | 5 | 5 |
| Cytochrom_B562 | PF07361 | Cytochrome b562 | 4 | 4 |
| D-ser_dehydrat | PF14031 | Putative serine dehydratase domain | 1 | 1 |
| DAC | PF02457 | DisA bacterial checkpoint controller nucleotide-binding | 3 | 2 |
| DAHP_synth_1 | PF00793 | DAHP synthetase I family | 40 | 40 |
| DAHP_synth_2 | PF01474 | Class-II DAHP synthetase family | 22 | 22 |
| DDE_Tnp_1 | PF01609 | Transposase DDE domain | 4 | 4 |
| DEAD | PF00270 | DEAD/DEAH box helicase | 5 | 5 |
| DHBP_synthase | PF00926 | 3,4-dihydroxy-2-butanone 4-phosphate synthase | 7 | 7 |
| DHDPS | PF00701 | Dihydrodipicolinate synthetase family | 1 | 1 |
| DHFR_1 | PF00186 | Dihydrofolate reductase | 21 | 20 |
| DHH | PF01368 | DHH family | 37 | 37 |
| DHHA1 | PF02272 | DHHA1 domain | 26 | 6 |
| DHHA2 | PF02833 | DHHA2 domain | 10 | 5 |
| DIOX_N | PF14226 | non-haem dioxygenase in morphine synthesis N-terminal | 14 | 1 |
| DNA_gyraseB_C | PF00986 | DNA gyrase B subunit, carboxyl terminus | 25 | 14 |
| DNA_ligase_A_M | PF01068 | ATP dependent DNA ligase domain | 4 | 3 |
| DNA_ligase_A_N | PF04675 | DNA ligase N terminus | 3 | 3 |
| DNA_ligase_OB_2 | PF14743 | DNA ligase OB-like domain | 1 | 1 |
| DNA_pack_C | PF02499 | Probable DNA packing protein, C-terminus | 2 | 2 |
| DNA_pol3_alpha | PF07733 | Bacterial DNA polymerase III alpha NTPase domain | 2 | 2 |
| DNA_pol_A | PF00476 | DNA polymerase family A | 28 | 23 |
| DNA_pol_A_exo1 | PF01612 | 3'-5' exonuclease | 30 | 19 |
| DNA_pol_B | PF00136 | DNA polymerase family B | 14 | 11 |
| DNA_pol_B_2 | PF03175 | DNA polymerase type B, organellar and viral | 1 | 1 |
| DNA_pol_B_3 | PF08408 | DNA polymerase family B viral insert | 1 | 1 |
| DNA_pol_B_exo1 | PF03104 | DNA polymerase family B, exonuclease domain | 13 | 6 |
| DNA_pol_B_palm | PF14792 | DNA polymerase beta palm | 143 | 142 |
| DNA_pol_B_thumb | PF14791 | DNA polymerase beta thumb | 143 | 48 |
| DNA_pol_lambd_f | PF10391 | Fingers domain of DNA polymerase lambda | 137 | 37 |
| DNA_primase_S | PF01896 | DNA primase small subunit | 14 | 14 |
| DNA_primase_lrg | PF04104 | Eukaryotic and archaeal DNA primase, large subunit | 2 | 1 |
| DNA_topoisoIV | PF00521 | DNA gyrase/topoisomerase IV, subunit A | 27 | 16 |
| DUF111 | PF01969 | Protein of unknown function DUF111 | 1 | 1 |
| DUF1479 | PF07350 | Protein of unknown function (DUF1479) | 1 | 1 |
| DUF1887 | PF09002 | Domain of unknown function (DUF1887) | 2 | 2 |
| DUF2202 | PF09968 | Uncharacterized protein domain (DUF2202) | 1 | 1 |
| DUF2383 | PF09537 | Domain of unknown function (DUF2383) | 1 | 1 |
| DUF3692 | PF12469 | CRISPR-associated protein | 5 | 4 |
| DUF4392 | PF14336 | Domain of unknown function (DUF4392) | 1 | 1 |
| DUF4962 | PF16332 | Domain of unknown function (DUF4962) | 4 | 4 |
| DUF550 | PF04447 | Protein of unknown function (DUF550) | 1 | 1 |
| DUF659 | PF04937 | Protein of unknown function (DUF 659) | 1 | 1 |
| DXPR_C | PF13288 | DXP reductoisomerase C-terminal domain | 34 | 1 |
| DXP_redisom_C | PF08436 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain | 34 | 34 |
| DXP_reductoisom | PF02670 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 34 | 31 |
| Death | PF00531 | Death domain | 2 | 1 |
| Dicer_N | PF17895 | Giardia Dicer N-terminal domain | 2 | 2 |
| Dimer_Tnp_hAT | PF05699 | hAT family C-terminal dimerisation region | 1 | 1 |
| DinB_2 | PF12867 | DinB superfamily | 1 | 1 |
| DisA-linker | PF10635 | DisA bacterial checkpoint controller linker region | 1 | 1 |
| DmpG_comm | PF07836 | DmpG-like communication domain | 2 | 1 |
| Dodecin | PF07311 | Dodecin | 1 | 1 |
| Dyp_perox | PF04261 | Dyp-type peroxidase family | 2 | 2 |
| E1-E2_ATPase | PF00122 | E1-E2 ATPase | 3 | 3 |
| E1_dh | PF00676 | Dehydrogenase E1 component | 23 | 20 |
| EAL | PF00563 | EAL domain | 3 | 3 |
| EF-hand_1 | PF00036 | EF hand | 3 | 1 |
| EF-hand_7 | PF13499 | EF-hand domain pair | 6 | 4 |
| EGF | PF00008 | EGF-like domain | 22 | 15 |
| ERCC4 | PF02732 | ERCC4 domain | 1 | 1 |
| EcoRI | PF02963 | Restriction endonuclease EcoRI | 1 | 1 |
| Endonuc-EcoRV | PF09233 | Restriction endonuclease EcoRV | 4 | 4 |
| Endonuc-HincII | PF09226 | Restriction endonuclease HincII | 3 | 3 |
| Endonuclease_5 | PF04493 | Endonuclease V | 6 | 6 |
| Endonuclease_NS | PF01223 | DNA/RNA non-specific endonuclease | 3 | 3 |
| Enolase_C | PF00113 | Enolase, C-terminal TIM barrel domain | 2 | 2 |
| Enolase_N | PF03952 | Enolase, N-terminal domain | 2 | 1 |
| Exo_endo_phos | PF03372 | Endonuclease/Exonuclease/phosphatase family | 16 | 15 |
| F420_ligase | PF01996 | F420-0:Gamma-glutamyl ligase | 4 | 4 |
| F420_oxidored | PF03807 | NADP oxidoreductase coenzyme F420-dependent | 1 | 1 |
| F5_F8_type_C | PF00754 | F5/8 type C domain | 2 | 1 |
| FAA_hydrolase | PF01557 | Fumarylacetoacetate (FAA) hydrolase family | 4 | 4 |
| FAD_binding_4 | PF01565 | FAD binding domain | 2 | 1 |
| FA_desaturase_2 | PF03405 | Fatty acid desaturase | 1 | 1 |
| FBPase | PF00316 | Fructose-1-6-bisphosphatase, N-terminal domain | 12 | 12 |
| FBPase_C | PF18913 | Fructose-1-6-bisphosphatase, C-terminal domain | 12 | 12 |
| FBPase_glpX | PF03320 | Bacterial fructose-1,6-bisphosphatase, glpX-encoded | 4 | 4 |
| FG-GAP | PF01839 | FG-GAP repeat | 35 | 11 |
| FGGY_C | PF02782 | FGGY family of carbohydrate kinases, C-terminal domain | 1 | 1 |
| FGGY_N | PF00370 | FGGY family of carbohydrate kinases, N-terminal domain | 1 | 1 |
| FTO_NTD | PF12933 | FTO catalytic domain | 5 | 5 |
| FUR | PF01475 | Ferric uptake regulator family | 8 | 8 |
| FUT8_N_cat | PF19745 | Alpha-(1,6)-fucosyltransferase N- and catalytic domains | 1 | 1 |
| Fam20C | PF06702 | Golgi casein kinase, C-terminal, Fam20 | 1 | 1 |
| Fe-ADH | PF00465 | Iron-containing alcohol dehydrogenase | 3 | 3 |
| Fe_dep_repr_C | PF02742 | Iron dependent repressor, metal binding and dimerisation domain | 11 | 11 |
| Fe_dep_repress | PF01325 | Iron dependent repressor, N-terminal DNA binding domain | 11 | 10 |
| FeoA | PF04023 | FeoA domain | 2 | 2 |
| Fer4_14 | PF13394 | 4Fe-4S single cluster domain | 1 | 1 |
| Ferritin | PF00210 | Ferritin-like domain | 8 | 8 |
| Flavi_DEAD | PF07652 | Flavivirus DEAD domain | 22 | 21 |
| Flavodoxin_1 | PF00258 | Flavodoxin | 1 | 1 |
| Flu_PA | PF00603 | Influenza RNA-dependent RNA polymerase subunit PA | 162 | 162 |
| Fringe | PF02434 | Fringe-like | 2 | 2 |
| Fucose_iso_C | PF02952 | L-fucose isomerase, C-terminal domain | 9 | 9 |
| Fucose_iso_N2 | PF07882 | L-fucose isomerase, second N-terminal domain | 9 | 9 |
| G-alpha | PF00503 | G-protein alpha subunit | 7 | 1 |
| GA | PF01468 | GA module | 1 | 1 |
| GCHY-1 | PF02649 | Type I GTP cyclohydrolase folE2 | 1 | 1 |
| GDA1_CD39 | PF01150 | GDA1/CD39 (nucleoside phosphatase) family | 1 | 1 |
| GH3 | PF03321 | GH3 auxin-responsive promoter | 1 | 1 |
| GHMP_kinases_N | PF00288 | GHMP kinases N terminal domain | 1 | 1 |
| GIY-YIG | PF01541 | GIY-YIG catalytic domain | 5 | 5 |
| GMC_oxred_C | PF05199 | GMC oxidoreductase | 3 | 2 |
| GMC_oxred_N | PF00732 | GMC oxidoreductase | 2 | 2 |
| GNT-I | PF03071 | GNT-I family | 6 | 6 |
| GPI | PF06560 | Glucose-6-phosphate isomerase (GPI) | 5 | 5 |
| GT-D | PF08759 | Glycosyltransferase GT-D fold | 1 | 1 |
| GTP_EFTU | PF00009 | Elongation factor Tu GTP binding domain | 2 | 2 |
| GalBD_like | PF17974 | Galactose-binding domain-like | 13 | 13 |
| Gal_mutarotas_3 | PF18080 | Galactose mutarotase-like fold domain | 13 | 8 |
| GatB_N | PF02934 | GatB/GatE catalytic domain | 2 | 2 |
| Gemini_AL1 | PF00799 | Geminivirus Rep catalytic domain | 4 | 4 |
| Gln-synt_C | PF00120 | Glutamine synthetase, catalytic domain | 17 | 17 |
| Gln-synt_N | PF03951 | Glutamine synthetase, beta-Grasp domain | 17 | 2 |
| Globin | PF00042 | Globin | 2 | 2 |
| Glutaredoxin | PF00462 | Glutaredoxin | 1 | 1 |
| Glyco_hydro_101 | PF12905 | Endo-alpha-N-acetylgalactosaminidase | 13 | 13 |
| Glyco_hydro_20 | PF00728 | Glycosyl hydrolase family 20, catalytic domain | 1 | 1 |
| Glyco_hydro_2_C | PF02836 | Glycosyl hydrolases family 2, TIM barrel domain | 1 | 1 |
| Glyco_hydro_4 | PF02056 | Family 4 glycosyl hydrolase | 8 | 8 |
| Glyco_hydro_4C | PF11975 | Family 4 glycosyl hydrolase C-terminal domain | 8 | 8 |
| Glyco_tranf_2_3 | PF13641 | Glycosyltransferase like family 2 | 5 | 5 |
| Glyco_tranf_2_5 | PF13712 | Glycosyltransferase like family | 1 | 1 |
| Glyco_transf_15 | PF01793 | Glycolipid 2-alpha-mannosyltransferase | 4 | 4 |
| Glyco_transf_24 | PF18404 | Glucosyltransferase 24 | 8 | 8 |
| Glyco_transf_34 | PF05637 | galactosyl transferase GMA12/MNN10 family | 7 | 7 |
| Glyco_transf_41 | PF13844 | Glycosyl transferase family 41 | 1 | 1 |
| Glyco_transf_43 | PF03360 | Glycosyltransferase family 43 | 5 | 5 |
| Glyco_transf_6 | PF03414 | Glycosyltransferase family 6 | 102 | 100 |
| Glyco_transf_64 | PF09258 | Glycosyl transferase family 64 domain | 7 | 7 |
| Glyco_transf_7C | PF02709 | N-terminal domain of galactosyltransferase | 31 | 22 |
| Glyco_transf_7N | PF13733 | N-terminal region of glycosyl transferase group 7 | 31 | 22 |
| Glyco_transf_8 | PF01501 | Glycosyl transferase family 8 | 27 | 26 |
| Glyco_transf_88 | PF16849 | Glycosyltransferase family 88 | 1 | 1 |
| Glyco_transf_92 | PF01697 | Glycosyltransferase family 92 | 1 | 1 |
| Glycos_transf_2 | PF00535 | Glycosyl transferase family 2 | 45 | 45 |
| Glycos_transf_3 | PF00591 | Glycosyl transferase family, a/b domain | 3 | 3 |
| Glyoxalase | PF00903 | Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily | 27 | 27 |
| Guanylate_cyc | PF00211 | Adenylate and Guanylate cyclase catalytic domain | 22 | 16 |
| GyrI-like | PF06445 | GyrI-like small molecule binding domain | 2 | 2 |
| HAGH_C | PF16123 | Hydroxyacylglutathione hydrolase C-terminus | 1 | 1 |
| HATPase_c | PF02518 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 4 | 2 |
| HD | PF01966 | HD domain | 17 | 12 |
| HD_4 | PF13328 | HD domain | 16 | 16 |
| HHH_5 | PF14520 | Helix-hairpin-helix domain | 3 | 1 |
| HHH_8 | PF14716 | Helix-hairpin-helix domain | 132 | 38 |
| HIF-1 | PF11413 | Hypoxia-inducible factor-1 | 5 | 5 |
| HMGL-like | PF00682 | HMGL-like | 29 | 29 |
| HNH | PF01844 | HNH endonuclease | 1 | 1 |
| HNH_3 | PF13392 | HNH endonuclease | 1 | 1 |
| HSP70 | PF00012 | Hsp70 protein | 1 | 1 |
| Ham1p_like | PF01725 | Ham1 family | 1 | 1 |
| Helicase_C | PF00271 | Helicase conserved C-terminal domain | 18 | 1 |
| Hemerythrin | PF01814 | Hemerythrin HHE cation binding domain | 3 | 3 |
| Hepar_II_III | PF07940 | Heparinase II/III-like protein | 4 | 4 |
| Hist_deacetyl | PF00850 | Histone deacetylase domain | 1 | 1 |
| Histone | PF00125 | Core histone H2A/H2B/H3/H4 | 95 | 90 |
| Histone_H2A_C | PF16211 | C-terminus of histone H2A | 95 | 3 |
| HpcH_HpaI | PF03328 | HpcH/HpaI aldolase/citrate lyase family | 3 | 3 |
| HutP | PF09021 | HutP | 1 | 1 |
| Hydantoinase_B | PF02538 | Hydantoinase B/oxoprolinase | 3 | 3 |
| Hydrophobin_2 | PF06766 | Fungal hydrophobin | 2 | 2 |
| ICL | PF00463 | Isocitrate lyase family | 1 | 1 |
| IDH | PF03971 | Monomeric isocitrate dehydrogenase | 3 | 3 |
| IGPD | PF00475 | Imidazoleglycerol-phosphate dehydratase | 26 | 22 |
| ILVD_EDD | PF00920 | Dehydratase family | 1 | 1 |
| IMS | PF00817 | impB/mucB/samB family | 64 | 64 |
| IPK | PF03770 | Inositol polyphosphate kinase | 3 | 3 |
| IlvC | PF01450 | Acetohydroxy acid isomeroreductase, catalytic domain | 1 | 1 |
| IlvN | PF07991 | Acetohydroxy acid isomeroreductase, NADPH-binding domain | 1 | 1 |
| Indigoidine_A | PF04227 | Indigoidine synthase A like protein | 5 | 5 |
| Inos-1-P_synth | PF01658 | Myo-inositol-1-phosphate synthase | 1 | 1 |
| Inositol_P | PF00459 | Inositol monophosphatase family | 7 | 7 |
| Ins134_P3_kin | PF05770 | Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain | 2 | 2 |
| Insulin | PF00049 | Insulin/IGF/Relaxin family | 2 | 2 |
| Integrin_alpha2 | PF08441 | Integrin alpha | 35 | 10 |
| Integrin_beta | PF00362 | Integrin beta chain VWA domain | 35 | 35 |
| Ion_trans | PF00520 | Ion transport protein | 1 | 1 |
| Iron_transport | PF10634 | Fe2+ transport protein | 2 | 2 |
| Iso_dh | PF00180 | Isocitrate/isopropylmalate dehydrogenase | 13 | 13 |
| JmjC | PF02373 | JmjC domain, hydroxylase | 147 | 145 |
| Kinesin | PF00225 | Kinesin motor domain | 1 | 1 |
| LAGLIDADG_1 | PF00961 | LAGLIDADG endonuclease | 7 | 7 |
| LAGLIDADG_2 | PF03161 | LAGLIDADG DNA endonuclease family | 1 | 1 |
| LAGLIDADG_3 | PF14528 | LAGLIDADG-like domain | 13 | 13 |
| L_protein_N | PF15518 | L protein N-terminus | 18 | 18 |
| Lactamase_B | PF00753 | Metallo-beta-lactamase superfamily | 4 | 4 |
| Lactamase_B_2 | PF12706 | Beta-lactamase superfamily domain | 11 | 11 |
| Lactamase_B_3 | PF13483 | Beta-lactamase superfamily domain | 1 | 1 |
| Lectin_legB | PF00139 | Legume lectin domain | 284 | 283 |
| LigD_N | PF13298 | DNA polymerase Ligase (LigD) | 4 | 4 |
| Lipoxygenase | PF00305 | Lipoxygenase | 5 | 5 |
| Lys | PF00062 | C-type lysozyme/alpha-lactalbumin family | 11 | 5 |
| LytR_cpsA_psr | PF03816 | LytR_cpsA_psr family | 1 | 1 |
| Lyx_isomer | PF07385 | D-lyxose isomerase | 5 | 5 |
| M20_dimer | PF07687 | Peptidase dimerisation domain | 6 | 3 |
| MGAT2 | PF05060 | N-acetylglucosaminyltransferase II (MGAT2) | 1 | 1 |
| MPTase-PolyVal | PF18818 | Zincin-like metallopeptidase | 1 | 1 |
| MR_MLE_C | PF13378 | Enolase C-terminal domain-like | 9 | 9 |
| MR_MLE_N | PF02746 | Mandelate racemase / muconate lactonizing enzyme, N-terminal domain | 9 | 1 |
| Mab-21 | PF03281 | Mab-21 protein | 6 | 6 |
| Maf | PF02545 | Maf-like protein | 1 | 1 |
| Malic_M | PF03949 | Malic enzyme, NAD binding domain | 9 | 1 |
| Man-6-P_recep | PF02157 | Mannose-6-phosphate receptor | 4 | 4 |
| Mannosyl_trans3 | PF11051 | Mannosyltransferase putative | 1 | 1 |
| MazG | PF03819 | MazG nucleotide pyrophosphohydrolase domain | 1 | 1 |
| Metalloenzyme | PF01676 | Metalloenzyme superfamily | 36 | 36 |
| Metallophos | PF00149 | Calcineurin-like phosphoesterase | 155 | 156 |
| Metallophos_2 | PF12850 | Calcineurin-like phosphoesterase superfamily domain | 11 | 11 |
| Methyltransf_3 | PF01596 | O-methyltransferase | 2 | 2 |
| MgtE | PF01769 | Divalent cation transporter | 1 | 1 |
| Mn_catalase | PF05067 | Manganese containing catalase | 4 | 4 |
| MoCF_biosynth | PF00994 | Probable molybdopterin binding domain | 1 | 1 |
| MobA_MobL | PF03389 | MobA/MobL family | 1 | 1 |
| Mob_Pre | PF01076 | Plasmid recombination enzyme | 5 | 5 |
| Molybdop_Fe4S4 | PF04879 | Molybdopterin oxidoreductase Fe4S4 domain | 1 | 1 |
| Mur_ligase_C | PF02875 | Mur ligase family, glutamate ligase domain | 4 | 3 |
| Mur_ligase_M | PF08245 | Mur ligase middle domain | 4 | 4 |
| Myosin_head | PF00063 | Myosin head (motor domain) | 1 | 1 |
| N6_Mtase | PF02384 | N-6 DNA Methylase | 1 | 1 |
| N6_N4_Mtase | PF01555 | DNA methylase | 1 | 1 |
| NADH_4Fe-4S | PF10589 | NADH-ubiquinone oxidoreductase-F iron-sulfur binding region | 1 | 1 |
| NADH_Oxid_Nqo15 | PF11497 | NADH-quinone oxidoreductase chain 15 | 1 | 1 |
| NAD_binding_5 | PF07994 | Myo-inositol-1-phosphate synthase | 1 | 1 |
| NAD_kinase | PF01513 | ATP-NAD kinase N-terminal domain | 1 | 1 |
| NRDD | PF13597 | Anaerobic ribonucleoside-triphosphate reductase | 1 | 1 |
| NTP_transf_2 | PF01909 | Nucleotidyltransferase domain | 10 | 10 |
| NTP_transf_3 | PF12804 | MobA-like NTP transferase domain | 2 | 2 |
| NTPase_P4 | PF11602 | ATPase P4 of dsRNA bacteriophage phi-12 | 3 | 3 |
| NUDIX | PF00293 | NUDIX domain | 57 | 57 |
| Na_Ca_ex | PF01699 | Sodium/calcium exchanger protein | 1 | 1 |
| NeuB | PF03102 | NeuB family | 8 | 8 |
| Nramp | PF01566 | Natural resistance-associated macrophage protein | 7 | 9 |
| NurA | PF09376 | NurA domain | 3 | 3 |
| O-FucT | PF10250 | GDP-fucose protein O-fucosyltransferase | 1 | 1 |
| P-II | PF00543 | Nitrogen regulatory protein P-II | 1 | 1 |
| PALP | PF00291 | Pyridoxal-phosphate dependent enzyme | 4 | 2 |
| PDDEXK_1 | PF12705 | PD-(D/E)XK nuclease superfamily | 1 | 1 |
| PDDEXK_9 | PF08011 | PD-(D/E)XK nuclease superfamily | 1 | 1 |
| PDEase_I | PF00233 | 3'5'-cyclic nucleotide phosphodiesterase | 10 | 9 |
| PDEase_II | PF02112 | cAMP phosphodiesterases class-II | 1 | 1 |
| PEPCK_ATP | PF01293 | Phosphoenolpyruvate carboxykinase | 11 | 11 |
| PEPCK_GTP | PF00821 | Phosphoenolpyruvate carboxykinase C-terminal P-loop domain | 61 | 61 |
| PEPCK_N | PF17297 | Phosphoenolpyruvate carboxykinase N-terminal domain | 61 | 58 |
| PEP_mutase | PF13714 | Phosphoenolpyruvate phosphomutase | 3 | 3 |
| PEPcase | PF00311 | Phosphoenolpyruvate carboxylase | 2 | 2 |
| PHP | PF02811 | PHP domain | 4 | 4 |
| PHP_C | PF13263 | PHP-associated | 1 | 1 |
| PI-PLC-X | PF00388 | Phosphatidylinositol-specific phospholipase C, X domain | 1 | 1 |
| PIN | PF01850 | PIN domain | 2 | 2 |
| PIN_4 | PF13638 | PIN domain | 1 | 1 |
| PIP5K | PF01504 | Phosphatidylinositol-4-phosphate 5-Kinase | 4 | 4 |
| PK | PF00224 | Pyruvate kinase, barrel domain | 14 | 14 |
| PK_Tyr_Ser-Thr | PF07714 | Protein tyrosine and serine/threonine kinase | 7 | 5 |
| PP-binding | PF00550 | Phosphopantetheine attachment site | 2 | 1 |
| PP2C | PF00481 | Protein phosphatase 2C | 31 | 31 |
| PP2C_2 | PF13672 | Protein phosphatase 2C | 8 | 8 |
| PPE | PF00823 | PPE family | 1 | 1 |
| PRA-PH | PF01503 | Phosphoribosyl-ATP pyrophosphohydrolase | 4 | 4 |
| PRCH | PF03967 | Photosynthetic reaction centre, H-chain N-terminal region | 3 | 1 |
| PRORP | PF16953 | Protein-only RNase P | 3 | 3 |
| PRTase_3 | PF15610 | PRTase ComF-like | 1 | 1 |
| PSII | PF00421 | Photosystem II protein | 5 | 1 |
| PTE | PF02126 | Phosphotriesterase family | 4 | 4 |
| PV_NSP1 | PF12433 | Parvovirus non-structural protein 1 | 1 | 1 |
| PadR | PF03551 | Transcriptional regulator PadR-like family | 5 | 5 |
| Pectate_lyase | PF03211 | Pectate lyase | 1 | 1 |
| Pectate_lyase22 | PF14583 | Oligogalacturonate lyase | 2 | 2 |
| Pectate_lyase_2 | PF06917 | Periplasmic pectate lyase | 2 | 2 |
| Pectate_lyase_3 | PF12708 | Pectate lyase superfamily protein | 4 | 2 |
| Peptidase_C26 | PF07722 | Peptidase C26 | 2 | 2 |
| Peptidase_M17 | PF00883 | Cytosol aminopeptidase family, catalytic domain | 12 | 12 |
| Peptidase_M18 | PF02127 | Aminopeptidase I zinc metalloprotease (M18) | 2 | 2 |
| Peptidase_M19 | PF01244 | Membrane dipeptidase (Peptidase family M19) | 1 | 1 |
| Peptidase_M20 | PF01546 | Peptidase family M20/M25/M40 | 10 | 10 |
| Peptidase_M24 | PF00557 | Metallopeptidase family M24 | 120 | 119 |
| Peptidase_M28 | PF04389 | Peptidase family M28 | 1 | 1 |
| Peptidase_M4 | PF01447 | Thermolysin metallopeptidase, catalytic domain | 1 | 1 |
| Peptidase_M4_C | PF02868 | Thermolysin metallopeptidase, alpha-helical domain | 1 | 1 |
| Peripla_BP_2 | PF01497 | Periplasmic binding protein | 1 | 1 |
| Peripla_BP_6 | PF13458 | Periplasmic binding protein | 1 | 1 |
| Peroxidase_2 | PF01328 | Peroxidase, family 2 | 14 | 14 |
| PfkB | PF00294 | pfkB family carbohydrate kinase | 2 | 2 |
| Phage_TAC_5 | PF08890 | Phage XkdN-like tail assembly chaperone protein, TAC | 1 | 1 |
| Phage_endo_I | PF05367 | Phage endonuclease I | 1 | 1 |
| Phage_lysozyme | PF00959 | Phage lysozyme | 1 | 1 |
| Phenol_Hydrox | PF02332 | Methane/Phenol/Toluene Hydroxylase | 2 | 2 |
| Phospholip_A2_1 | PF00068 | Phospholipase A2 | 1 | 1 |
| Photo_RC | PF00124 | Photosynthetic reaction centre protein | 8 | 7 |
| PhyH | PF05721 | Phytanoyl-CoA dioxygenase (PhyH) | 2 | 2 |
| Pirin | PF02678 | Pirin | 4 | 4 |
| Piwi | PF02171 | Piwi domain | 5 | 5 |
| Pkinase | PF00069 | Protein kinase domain | 42 | 41 |
| PriX | PF18689 | Primase X | 1 | 1 |
| Pribosyltran | PF00156 | Phosphoribosyl transferase domain | 1 | 1 |
| Prim-Pol | PF09250 | Bifunctional DNA primase/polymerase, N-terminal | 1 | 1 |
| PsbP | PF01789 | PsbP | 1 | 1 |
| Pterin_bind | PF00809 | Pterin binding enzyme | 1 | 1 |
| Pyrophosphatase | PF00719 | Inorganic pyrophosphatase | 15 | 15 |
| QRPTase_C | PF01729 | Quinolinate phosphoribosyl transferase, C-terminal domain | 1 | 1 |
| QRPTase_N | PF02749 | Quinolinate phosphoribosyl transferase, N-terminal domain | 1 | 1 |
| RAG1 | PF12940 | Recombination-activation protein 1 (RAG1), recombinase | 5 | 5 |
| RAI1 | PF08652 | RAI1 like PD-(D/E)XK nuclease | 3 | 3 |
| RE_HindIII | PF09518 | HindIII restriction endonuclease | 5 | 5 |
| RGP | PF03214 | Reversibly glycosylated polypeptide | 5 | 5 |
| RIO1 | PF01163 | RIO1 family | 4 | 4 |
| RMMBL | PF07521 | Zn-dependent metallo-hydrolase RNA specificity domain | 7 | 1 |
| RNA_lig_T4_1 | PF09511 | RNA ligase | 2 | 2 |
| RNA_ligase | PF09414 | RNA ligase | 8 | 8 |
| RNA_pol_Rpb1_2 | PF00623 | RNA polymerase Rpb1, domain 2 | 10 | 8 |
| RNA_pol_Rpb2_6 | PF00562 | RNA polymerase Rpb2, domain 6 | 10 | 6 |
| RNB | PF00773 | RNB domain | 1 | 1 |
| RNase_H | PF00075 | RNase H | 50 | 48 |
| RNase_HII | PF01351 | Ribonuclease HII | 2 | 2 |
| RNase_J_C | PF17770 | Ribonuclease J C-terminal domain | 4 | 2 |
| RNase_PH | PF01138 | 3' exoribonuclease family, domain 1 | 2 | 2 |
| RNase_PH_C | PF03725 | 3' exoribonuclease family, domain 2 | 2 | 1 |
| RNase_P_p30 | PF01876 | RNase P subunit p30 | 1 | 1 |
| RNase_T | PF00929 | Exonuclease | 15 | 15 |
| RTC | PF01137 | RNA 3'-terminal phosphate cyclase | 1 | 1 |
| RVT_1 | PF00078 | Reverse transcriptase (RNA-dependent DNA polymerase) | 21 | 5 |
| RVT_3 | PF13456 | Reverse transcriptase-like | 2 | 2 |
| RapH_N | PF18801 | response regulator aspartate phosphatase H, N terminal | 1 | 1 |
| Rcd1 | PF04078 | Cell differentiation family, Rcd1-like | 1 | 1 |
| RdRP_1 | PF00680 | Viral RNA-dependent RNA polymerase | 33 | 28 |
| RdRP_3 | PF00998 | Viral RNA dependent RNA polymerase | 23 | 23 |
| RdRP_5 | PF07925 | Reovirus RNA-dependent RNA polymerase lambda 3 | 5 | 5 |
| RecA | PF00154 | recA bacterial DNA recombination protein | 1 | 1 |
| Rep_2 | PF01719 | Plasmid replication protein | 5 | 5 |
| Rep_N | PF08724 | Rep protein catalytic domain like | 2 | 2 |
| ResIII | PF04851 | Type III restriction enzyme, res subunit | 1 | 1 |
| Response_reg | PF00072 | Response regulator receiver domain | 41 | 40 |
| RhaA | PF06134 | L-rhamnose isomerase (RhaA) | 5 | 5 |
| Rhodanese | PF00581 | Rhodanese-like domain | 2 | 2 |
| Ribonuc_red_sm | PF00268 | Ribonucleotide reductase, small chain | 54 | 54 |
| Ribonucleas_3_3 | PF14622 | Ribonuclease-III-like | 3 | 3 |
| Ribonuclease_T2 | PF00445 | Ribonuclease T2 family | 1 | 1 |
| Ribosomal_L13 | PF00572 | Ribosomal protein L13 | 7 | 7 |
| Ribosomal_L16 | PF00252 | Ribosomal protein L16p/L10e | 8 | 6 |
| Ribosomal_L17 | PF01196 | Ribosomal protein L17 | 7 | 1 |
| Ribosomal_L19 | PF01245 | Ribosomal protein L19 | 7 | 7 |
| Ribosomal_L2 | PF00181 | Ribosomal Proteins L2, RNA binding domain | 7 | 1 |
| Ribosomal_L20 | PF00453 | Ribosomal protein L20 | 7 | 4 |
| Ribosomal_L21p | PF00829 | Ribosomal prokaryotic L21 protein | 7 | 1 |
| Ribosomal_L23 | PF00276 | Ribosomal protein L23 | 7 | 3 |
| Ribosomal_L25p | PF01386 | Ribosomal L25p family | 7 | 1 |
| Ribosomal_L27 | PF01016 | Ribosomal L27 protein | 7 | 5 |
| Ribosomal_L27A | PF00828 | Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A | 8 | 8 |
| Ribosomal_L28 | PF00830 | Ribosomal L28 family | 5 | 1 |
| Ribosomal_L2_C | PF03947 | Ribosomal Proteins L2, C-terminal domain | 10 | 10 |
| Ribosomal_L3 | PF00297 | Ribosomal protein L3 | 7 | 7 |
| Ribosomal_L30 | PF00327 | Ribosomal protein L30p/L7e | 7 | 1 |
| Ribosomal_L32p | PF01783 | Ribosomal L32p protein family | 7 | 4 |
| Ribosomal_L34 | PF00468 | Ribosomal protein L34 | 7 | 5 |
| Ribosomal_L35p | PF01632 | Ribosomal protein L35 | 7 | 2 |
| Ribosomal_L36 | PF00444 | Ribosomal protein L36 | 4 | 2 |
| Ribosomal_L4 | PF00573 | Ribosomal protein L4/L1 family | 7 | 7 |
| RimK | PF08443 | RimK-like ATP-grasp domain | 1 | 1 |
| RsfS | PF02410 | Ribosomal silencing factor during starvation | 1 | 1 |
| RtcB | PF01139 | tRNA-splicing ligase RtcB | 6 | 6 |
| Rubrerythrin | PF02915 | Rubrerythrin | 3 | 3 |
| RuvC_III | PF18541 | RuvC endonuclease subdomain 3 | 2 | 2 |
| S1 | PF00575 | S1 RNA binding domain | 4 | 1 |
| SAM_PNT | PF02198 | Sterile alpha motif (SAM)/Pointed domain | 1 | 1 |
| SBP_bac_1 | PF01547 | Bacterial extracellular solute-binding protein | 2 | 1 |
| SBP_bac_5 | PF00496 | Bacterial extracellular solute-binding proteins, family 5 Middle | 2 | 2 |
| SBP_bac_8 | PF13416 | Bacterial extracellular solute-binding protein | 1 | 1 |
| SQS_PSY | PF00494 | Squalene/phytoene synthase | 1 | 1 |
| SRP54 | PF00448 | SRP54-type protein, GTPase domain | 1 | 1 |
| START | PF01852 | START domain | 1 | 1 |
| STPPase_N | PF16891 | Serine-threonine protein phosphatase N-terminal domain | 76 | 1 |
| STT3 | PF02516 | Oligosaccharyl transferase STT3 subunit | 4 | 4 |
| S_100 | PF01023 | S-100/ICaBP type calcium binding domain | 3 | 2 |
| Seadorna_VP7 | PF07387 | Seadornavirus VP7 | 1 | 1 |
| Sec7 | PF01369 | Sec7 domain | 1 | 1 |
| SelO | PF02696 | Protein adenylyltransferase SelO | 1 | 1 |
| Semialdhyde_dh | PF01118 | Semialdehyde dehydrogenase, NAD binding domain | 2 | 1 |
| Shikimate_dh_N | PF08501 | Shikimate dehydrogenase substrate binding domain | 1 | 1 |
| Sigma70_ECF | PF07638 | ECF sigma factor | 1 | 1 |
| Sod_Fe_C | PF02777 | Iron/manganese superoxide dismutases, C-terminal domain | 94 | 94 |
| Sod_Fe_N | PF00081 | Iron/manganese superoxide dismutases, alpha-hairpin domain | 94 | 94 |
| SoxY | PF13501 | Sulfur oxidation protein SoxY | 1 | 1 |
| SpoIIE | PF07228 | Stage II sporulation protein E (SpoIIE) | 8 | 8 |
| Squash | PF00299 | Squash family serine protease inhibitor | 2 | 2 |
| Sulfatase | PF00884 | Sulfatase | 9 | 10 |
| SurE | PF01975 | Survival protein SurE | 6 | 6 |
| TAF | PF02969 | TATA box binding protein associated factor (TAF) | 95 | 1 |
| TGFb_propeptide | PF00688 | TGF-beta propeptide | 2 | 2 |
| TOPRIM_C | PF16898 | C-terminal associated domain of TOPRIM | 2 | 1 |
| TPP_enzyme_C | PF02775 | Thiamine pyrophosphate enzyme, C-terminal TPP binding domain | 14 | 14 |
| TPP_enzyme_M_2 | PF16582 | Middle domain of thiamine pyrophosphate | 13 | 1 |
| TPR_1 | PF00515 | Tetratricopeptide repeat | 4 | 1 |
| Taq-exonuc | PF09281 | Taq polymerase, exonuclease | 14 | 1 |
| TatD_DNase | PF01026 | TatD related DNase | 1 | 1 |
| TauD | PF02668 | Taurine catabolism dioxygenase TauD, TfdA family | 5 | 5 |
| TcdA_TcdB | PF12919 | TcdA/TcdB catalytic glycosyltransferase domain | 19 | 19 |
| Terminase_3C | PF17288 | Terminase RNAseH like domain | 3 | 3 |
| Terminase_6C | PF17289 | Terminase RNaseH-like domain | 1 | 1 |
| Terpene_syn_C_2 | PF19086 | Terpene synthase family 2, C-terminal metal binding | 2 | 2 |
| Terpene_synth_C | PF03936 | Terpene synthase family, metal binding domain | 5 | 5 |
| Tet_JBP | PF12851 | Oxygenase domain of the 2OGFeDO superfamily | 3 | 3 |
| Toprim | PF01751 | Toprim domain | 27 | 27 |
| Toprim_4 | PF13662 | Toprim domain | 6 | 6 |
| Toprim_N | PF08275 | DNA primase catalytic core, N-terminal domain | 6 | 6 |
| Translin | PF01997 | Translin family | 1 | 1 |
| Transthyretin | PF00576 | HIUase/Transthyretin family | 1 | 1 |
| Trp_dioxygenase | PF03301 | Tryptophan 2,3-dioxygenase | 2 | 2 |
| TrwC | PF08751 | TrwC relaxase | 2 | 2 |
| TsaD | PF00814 | tRNA N6-adenosine threonylcarbamoyltransferase | 1 | 1 |
| Tubulin | PF00091 | Tubulin/FtsZ family, GTPase domain | 2 | 2 |
| TxDE | PF18711 | Toxoflavin-degrading enzyme | 4 | 4 |
| UPF0489 | PF12640 | UPF0489 domain | 1 | 1 |
| UbiD | PF01977 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase | 61 | 61 |
| Usp | PF00582 | Universal stress protein family | 1 | 1 |
| UvdE | PF03851 | UV-endonuclease UvdE | 5 | 5 |
| UvrC_HhH_N | PF08459 | UvrC RIbonuclease H-like domain | 1 | 1 |
| UxaE | PF16257 | tagaturonate epimerase | 1 | 1 |
| UxuA | PF03786 | D-mannonate dehydratase (UxuA) | 5 | 5 |
| V-set | PF07686 | Immunoglobulin V-set domain | 47 | 2 |
| VRR_NUC | PF08774 | VRR-NUC domain | 2 | 2 |
| VTC | PF09359 | VTC domain | 2 | 2 |
| VWA | PF00092 | von Willebrand factor type A domain | 12 | 12 |
| Viral_Rep | PF02407 | Putative viral replication protein | 3 | 3 |
| WD40 | PF00400 | WD domain, G-beta repeat | 3 | 2 |
| XPG_I | PF00867 | XPG I-region | 16 | 16 |
| XPG_N | PF00752 | XPG N-terminal domain | 16 | 16 |
| XRN_M | PF17846 | Xrn1 helical domain | 1 | 1 |
| XRN_N | PF03159 | XRN 5'-3' exonuclease N-terminus | 1 | 1 |
| Y1_Tnp | PF01797 | Transposase IS200 like | 4 | 4 |
| YgbB | PF02542 | YgbB family | 6 | 6 |
| YmdB | PF13277 | YmdB-like protein | 5 | 5 |
| ZT_dimer | PF16916 | Dimerisation domain of Zinc Transporter | 1 | 1 |
| ZnuA | PF01297 | Zinc-uptake complex component A periplasmic | 21 | 21 |
| adh_short_C2 | PF13561 | Enoyl-(Acyl carrier protein) reductase | 4 | 4 |
| fn3 | PF00041 | Fibronectin type III domain | 6 | 5 |
| hEGF | PF12661 | Human growth factor-like EGF | 1 | 2 |
| mRNA_cap_enzyme | PF01331 | mRNA capping enzyme, catalytic domain | 1 | 1 |
| mRNA_triPase | PF02940 | mRNA capping enzyme, beta chain | 3 | 3 |
| malic | PF00390 | Malic enzyme, N-terminal domain | 9 | 9 |
| p450 | PF00067 | Cytochrome P450 | 2 | 2 |
| peroxidase | PF00141 | Peroxidase | 11 | 10 |
| polyprenyl_synt | PF00348 | Polyprenyl synthetase | 8 | 8 |
| ribosomal_L24 | PF17136 | Ribosomal proteins 50S L24/mitochondrial 39S L24 | 7 | 4 |
| rve | PF00665 | Integrase core domain | 12 | 12 |
| tRNA-synt_1b | PF00579 | tRNA synthetases class I (W and Y) | 1 | 1 |
| tRNA-synt_1c | PF00749 | tRNA synthetases class I (E and Q), catalytic domain | 1 | 1 |
| tRNA-synt_1c_C | PF03950 | tRNA synthetases class I (E and Q), anti-codon binding domain | 1 | 1 |
| tRNA-synt_2 | PF00152 | tRNA synthetases class II (D, K and N) | 2 | 2 |
| tRNA-synt_2b | PF00587 | tRNA synthetase class II core domain (G, H, P, S and T) | 1 | 1 |
| tRNA-synt_2d | PF01409 | tRNA synthetases class II core domain (F) | 3 | 2 |
| tRNA_NucTransf2 | PF09249 | tRNA nucleotidyltransferase, second domain | 6 | 2 |
| tRNA_m1G_MT | PF01746 | tRNA (Guanine-1)-methyltransferase | 1 | 1 |
| z-alpha | PF02295 | Adenosine deaminase z-alpha domain | 1 | 1 |
| zf-C5HC2 | PF02928 | C5HC2 zinc finger | 54 | 13 |
| zf-CCHC | PF00098 | Zinc knuckle | 4 | 1 |