#Pfams = 1881
| 14-3-3 | PF00244 | 14-3-3 protein | 419 | 429 | Y |
| 2Fe-2S_thioredx | PF01257 | Thioredoxin-like [2Fe-2S] ferredoxin | 26 | 57 | N |
| 2-Hacid_dh_C | PF02826 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain | 2 | 1 | N |
| 2OG-FeII_Oxy_3 | PF13640 | 2OG-Fe(II) oxygenase superfamily | 15 | 15 | N |
| 2-oxoacid_dh | PF00198 | 2-oxoacid dehydrogenases acyltransferase (catalytic domain) | 1 | 1 | N |
| 53-BP1_Tudor | PF09038 | Tumour suppressor p53-binding protein-1 Tudor | 9 | 9 | N |
| 7kD_DNA_binding | PF02294 | 7kD DNA-binding domain | 2 | 2 | N |
| 7tm_1 | PF00001 | 7 transmembrane receptor (rhodopsin family) | 187 | 181 | N |
| 7tm_2 | PF00002 | 7 transmembrane receptor (Secretin family) | 26 | 84 | N |
| 7tm_4 | PF13853 | Olfactory receptor | 1 | 1 | N |
| 7TM_GPCR_Srab | PF10292 | Serpentine type 7TM GPCR receptor class ab chemoreceptor | 0 | 1 | N |
| A2M | PF00207 | Alpha-2-macroglobulin family | 2 | 2 | N |
| A2M_BRD | PF07703 | Alpha-2-macroglobulin bait region domain | 2 | 4 | N |
| AA_permease_2 | PF13520 | Amino acid permease | 1 | 1 | N |
| AAA | PF00004 | ATPase family associated with various cellular activities (AAA) | 97 | 100 | N |
| AAA_16 | PF13191 | AAA ATPase domain | 1 | 1 | N |
| AAA_2 | PF07724 | AAA domain (Cdc48 subfamily) | 47 | 45 | N |
| AAA_23 | PF13476 | AAA domain | 1 | 4 | N |
| AAA_lid_3 | PF17862 | AAA+ lid domain | 31 | 2 | N |
| ABC_membrane | PF00664 | ABC transporter transmembrane region | 16 | 15 | N |
| ABC_tran | PF00005 | ABC transporter | 47 | 15 | N |
| ABC_tran_CTD | PF16326 | ABC transporter C-terminal domain | 1 | 3 | N |
| Abhydrolase_1 | PF00561 | alpha/beta hydrolase fold | 2 | 2 | N |
| Abi_HHR | PF07815 | Abl-interactor HHR | 1 | 1 | N |
| AbrB_C | PF18277 | AbrB C-terminal domain | 0 | 1 | N |
| AcetDehyd-dimer | PF09290 | Prokaryotic acetaldehyde dehydrogenase, dimerisation | 1 | 1 | N |
| Acetyltransf_1 | PF00583 | Acetyltransferase (GNAT) family | 37 | 34 | N |
| Acetyltransf_10 | PF13673 | Acetyltransferase (GNAT) domain | 1 | 1 | N |
| Acetyltransf_11 | PF13720 | Udp N-acetylglucosamine O-acyltransferase; Domain 2 | 4 | 3 | N |
| Acetyltransf_13 | PF13880 | ESCO1/2 acetyl-transferase | 2 | 2 | N |
| Acetyltransf_16 | PF05301 | GNAT acetyltransferase, Mec-17 | 2 | 2 | N |
| Acetyltransf_17 | PF17668 | Acetyltransferase (GNAT) domain | 1 | 1 | N |
| Acetyltransf_7 | PF13508 | Acetyltransferase (GNAT) domain | 0 | 6 | N |
| Acetyltransf_9 | PF13527 | Acetyltransferase (GNAT) domain | 1 | 1 | N |
| AChE_tetra | PF08674 | Acetylcholinesterase tetramerisation domain | 2 | 2 | N |
| ACR_tran | PF00873 | AcrB/AcrD/AcrF family | 3 | 8 | N |
| ActA | PF05058 | ActA Protein | 2 | 1 | N |
| Actin | PF00022 | Actin | 86 | 65 | N |
| Acyl_transf_1 | PF00698 | Acyl transferase domain | 4 | 4 | N |
| Acyl-CoA_dh_M | PF02770 | Acyl-CoA dehydrogenase, middle domain | 1 | 1 | N |
| Acyl-CoA_dh_N | PF02771 | Acyl-CoA dehydrogenase, N-terminal domain | 1 | 1 | N |
| Adap_comp_sub | PF00928 | Adaptor complexes medium subunit family | 37 | 44 | Y |
| Adaptin_binding | PF10199 | Alpha and gamma adaptin binding protein p34 | 0 | 1 | N |
| Adaptin_N | PF01602 | Adaptin N terminal region | 13 | 3 | N |
| ADD_ATRX | PF17981 | Cysteine Rich ADD domain | 5 | 5 | N |
| ADD_DNMT3 | PF17980 | Cysteine rich ADD domain in DNMT3 | 5 | 5 | N |
| Adeno_hexon | PF01065 | Hexon, adenovirus major coat protein, N-terminal domain | 7 | 6 | N |
| Adeno_hexon_C | PF03678 | Hexon, adenovirus major coat protein, C-terminal domain | 5 | 4 | N |
| Adeno_Penton_B | PF01686 | Adenovirus penton base protein | 8 | 6 | N |
| Adeno_PVIII | PF01310 | Adenovirus hexon associated protein, protein VIII | 6 | 3 | N |
| AdenylateSensor | PF16579 | Adenylate sensor of SNF1-like protein kinase | 1 | 1 | N |
| ADH_N | PF08240 | Alcohol dehydrogenase GroES-like domain | 1 | 1 | N |
| adh_short_C2 | PF13561 | Enoyl-(Acyl carrier protein) reductase | 4 | 1 | N |
| ADH_zinc_N | PF00107 | Zinc-binding dehydrogenase | 1 | 1 | N |
| ADP_ribosyl_GH | PF03747 | ADP-ribosylglycohydrolase | 4 | 4 | N |
| Agenet | PF05641 | Agenet domain | 5 | 5 | N |
| Agglutinin_C | PF18021 | Agglutinin C-terminal | 6 | 6 | N |
| AHD | PF17793 | ANC1 homology domain (AHD) | 2 | 3 | N |
| AIF_C | PF14721 | Apoptosis-inducing factor, mitochondrion-associated, C-term | 1 | 1 | N |
| AKAP7_RIRII_bdg | PF10470 | PKA-RI-RII subunit binding domain of A-kinase anchor protein | 0 | 1 | N |
| Alfin | PF12165 | Alfin | 3 | 3 | N |
| ALIX_LYPXL_bnd | PF13949 | ALIX V-shaped domain binding to HIV | 6 | 6 | N |
| Alk_phosphatase | PF00245 | Alkaline phosphatase | 7 | 1 | N |
| Alpha_adaptin_C | PF02296 | Alpha adaptin AP2, C-terminal domain | 9 | 7 | N |
| Alpha_adaptinC2 | PF02883 | Adaptin C-terminal domain | 20 | 14 | N |
| Alpha_E1_glycop | PF01589 | Alphavirus E1 glycoprotein | 1 | 2 | N |
| Alpha_E2_glycop | PF00943 | Alphavirus E2 glycoprotein | 0 | 1 | N |
| Alpha-amylase | PF00128 | Alpha amylase, catalytic domain | 2 | 4 | N |
| AMA-1 | PF02430 | Apical membrane antigen 1 | 9 | 11 | N |
| Amidase | PF01425 | Amidase | 2 | 2 | N |
| Amidase_2 | PF01510 | N-acetylmuramoyl-L-alanine amidase | 9 | 9 | N |
| Amidase_3 | PF01520 | N-acetylmuramoyl-L-alanine amidase | 0 | 1 | N |
| Amino_oxidase | PF01593 | Flavin containing amine oxidoreductase | 28 | 27 | N |
| Aminotran_1_2 | PF00155 | Aminotransferase class I and II | 1 | 2 | N |
| AMO | PF02461 | Ammonia monooxygenase | 5 | 1 | N |
| AmoC | PF04896 | Ammonia monooxygenase/methane monooxygenase, subunit C | 6 | 6 | N |
| AMP_N | PF05195 | Aminopeptidase P, N-terminal domain | 8 | 1 | N |
| AMP-binding_C | PF13193 | AMP-binding enzyme C-terminal domain | 9 | 1 | N |
| AMPKBI | PF04739 | 5'-AMP-activated protein kinase beta subunit, interaction domain | 1 | 1 | N |
| An_peroxidase | PF03098 | Animal haem peroxidase | 1 | 1 | N |
| ANAPC10 | PF03256 | Anaphase-promoting complex, subunit 10 (APC10) | 6 | 1 | N |
| ANAPC3 | PF12895 | Anaphase-promoting complex, cyclosome, subunit 3 | 7 | 1 | N |
| ANAPC4_WD40 | PF12894 | Anaphase-promoting complex subunit 4 WD40 domain | 13 | 2 | N |
| ANATO | PF01821 | Anaphylotoxin-like domain | 1 | 1 | N |
| ANF_receptor | PF01094 | Receptor family ligand binding region | 10 | 11 | N |
| Ank | PF00023 | Ankyrin repeat | 19 | 7 | N |
| Ank_2 | PF12796 | Ankyrin repeats (3 copies) | 66 | 46 | N |
| Ank_4 | PF13637 | Ankyrin repeats (many copies) | 16 | 15 | N |
| Ank_5 | PF13857 | Ankyrin repeats (many copies) | 11 | 3 | N |
| Annexin | PF00191 | Annexin | 19 | 3 | N |
| Anthrax-tox_M | PF09156 | Anthrax toxin lethal factor, middle domain | 3 | 3 | N |
| Antimicrobial_8 | PF08103 | Uperin family | 3 | 2 | N |
| Antimicrobial20 | PF08256 | Aurein-like antibiotic peptide | 7 | 1 | N |
| APC_rep | PF18797 | Adenomatous polyposis coli (APC) repeat | 12 | 12 | N |
| APC1_C | PF18122 | Anaphase-promoting complex sub unit 1 C-terminal domain | 6 | 2 | N |
| APG12 | PF04110 | Ubiquitin-like autophagy protein Apg12 | 1 | 2 | N |
| APG5 | PF04106 | Autophagy protein Apg5 | 1 | 3 | N |
| APG6_N | PF17675 | Apg6 coiled-coil region | 2 | 2 | N |
| APH | PF01636 | Phosphotransferase enzyme family | 2 | 2 | N |
| Apidaecin | PF00807 | Apidaecin | 11 | 1 | N |
| ApoC-I | PF04691 | Apolipoprotein C-I (ApoC-1) | 4 | 2 | N |
| Apocytochr_F_C | PF01333 | Apocytochrome F, C-terminal | 17 | 18 | N |
| Apocytochr_F_N | PF16639 | Apocytochrome F, N-terminal | 17 | 16 | N |
| APP_amyloid | PF10515 | Beta-amyloid precursor protein C-terminus | 19 | 3 | N |
| Arc_MA | PF19284 | Arc MA domain | 0 | 1 | N |
| ARC6-like_IMS | PF13355 | ARC6-like, IMS domain | 2 | 2 | N |
| Arf | PF00025 | ADP-ribosylation factor family | 5 | 1 | N |
| ArgoMid | PF16487 | Mid domain of argonaute | 1 | 1 | N |
| aRib | PF18938 | Atypical Rib domain | 0 | 1 | N |
| ARID | PF01388 | ARID/BRIGHT DNA binding domain | 6 | 5 | N |
| Arm | PF00514 | Armadillo/beta-catenin-like repeat | 148 | 163 | N |
| Arm_3 | PF16186 | Atypical Arm repeat | 116 | 11 | N |
| Arrestin_C | PF02752 | Arrestin (or S-antigen), C-terminal domain | 23 | 18 | N |
| Arrestin_N | PF00339 | Arrestin (or S-antigen), N-terminal domain | 24 | 20 | N |
| ARS2 | PF04959 | Arsenite-resistance protein 2 | 1 | 1 | N |
| ArsA_ATPase | PF02374 | Anion-transporting ATPase | 1 | 4 | N |
| Arylesterase | PF01731 | Arylesterase | 10 | 10 | N |
| ASC | PF00858 | Amiloride-sensitive sodium channel | 0 | 3 | N |
| ASF1_hist_chap | PF04729 | ASF1 like histone chaperone | 16 | 15 | N |
| Asp | PF00026 | Eukaryotic aspartyl protease | 77 | 79 | N |
| Asp_Arg_Hydrox | PF05118 | Aspartyl/Asparaginyl beta-hydroxylase | 2 | 18 | N |
| Asparaginase | PF00710 | Asparaginase, N-terminal | 2 | 1 | N |
| Asparaginase_C | PF17763 | Glutaminase/Asparaginase C-terminal domain | 2 | 1 | N |
| Astacin | PF01400 | Astacin (Peptidase family M12A) | 1 | 1 | N |
| ATG11 | PF10377 | Autophagy-related protein 11 | 2 | 2 | N |
| ATG14 | PF10186 | Vacuolar sorting 38 and autophagy-related subunit 14 | 4 | 2 | N |
| ATG16 | PF08614 | Autophagy protein 16 (ATG16) | 2 | 2 | N |
| ATG17_like | PF04108 | Autophagy protein ATG17-like domain | 2 | 2 | N |
| ATG7_N | PF16420 | Ubiquitin-like modifier-activating enzyme ATG7 N-terminus | 1 | 1 | N |
| ATG8 | PF02991 | Autophagy protein Atg8 ubiquitin like | 44 | 47 | N |
| ATLF | PF07737 | Anthrax toxin lethal factor, N- and C-terminal domain | 16 | 16 | N |
| ATP13 | PF12921 | Mitochondrial ATPase expression | 4 | 4 | N |
| ATP1G1_PLM_MAT8 | PF02038 | ATP1G1/PLM/MAT8 family | 2 | 1 | N |
| ATP-synt | PF00231 | ATP synthase | 10 | 36 | N |
| ATP-synt_8 | PF00895 | ATP synthase protein 8 | 5 | 2 | N |
| ATP-synt_A | PF00119 | ATP synthase A chain | 11 | 24 | N |
| ATP-synt_ab | PF00006 | ATP synthase alpha/beta family, nucleotide-binding domain | 11 | 1 | N |
| ATP-synt_ab_N | PF02874 | ATP synthase alpha/beta family, beta-barrel domain | 10 | 1 | N |
| ATP-synt_C | PF00137 | ATP synthase subunit C | 16 | 19 | N |
| ATP-synt_DE | PF00401 | ATP synthase, Delta/Epsilon chain, long alpha-helix domain | 4 | 16 | N |
| ATP-synt_DE_N | PF02823 | ATP synthase, Delta/Epsilon chain, beta-sandwich domain | 9 | 34 | N |
| ATP-synt_J | PF04911 | ATP synthase j chain | 1 | 32 | N |
| ATP-synt_S1 | PF05827 | Vacuolar ATP synthase subunit S1 (ATP6S1) | 0 | 1 | N |
| Autoind_bind | PF03472 | Autoinducer binding domain | 1 | 1 | N |
| Avidin | PF01382 | Avidin family | 48 | 50 | N |
| AWS | PF17907 | AWS domain | 7 | 6 | N |
| Ax_dynein_light | PF10211 | Axonemal dynein light chain | 0 | 4 | N |
| AXH | PF08517 | Ataxin-1 and HBP1 module (AXH) | 3 | 3 | N |
| B | PF02216 | B domain | 9 | 3 | N |
| B1 | PF02246 | Protein L b1 domain | 7 | 7 | N |
| B2-adapt-app_C | PF09066 | Beta2-adaptin appendage, C-terminal sub-domain | 6 | 2 | N |
| B56 | PF01603 | Protein phosphatase 2A regulatory B subunit (B56 family) | 9 | 10 | N |
| bacHORMA_2 | PF18173 | Bacterial HORMA domain 2 | 2 | 2 | N |
| BAF | PF02961 | Barrier to autointegration factor | 0 | 3 | N |
| BaffR-Tall_bind | PF09256 | BAFF-R, TALL-1 binding | 3 | 1 | N |
| BAH | PF01426 | BAH domain | 16 | 13 | N |
| Bap31_Bap29_C | PF18035 | Bap31/Bap29 cytoplasmic coiled-coil domain | 0 | 1 | N |
| BB_PF | PF18063 | Beta barrel Pore-forming domain | 2 | 2 | N |
| BBE | PF08031 | Berberine and berberine like | 1 | 1 | N |
| Bcl-2 | PF00452 | Apoptosis regulator proteins, Bcl-2 family | 132 | 130 | Y |
| Bcl-2_3 | PF15286 | Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like | 3 | 3 | N |
| Bclx_interact | PF08945 | Bcl-x interacting, BH3 domain | 49 | 7 | N |
| bCoV_S1_N | PF16451 | Betacoronavirus-like spike glycoprotein S1, N-terminal | 17 | 3 | N |
| bCoV_S1_RBD | PF09408 | Betacoronavirus spike glycoprotein S1, receptor binding | 18 | 5 | N |
| BcsB | PF03170 | Bacterial cellulose synthase subunit | 5 | 5 | N |
| BET | PF17035 | Bromodomain extra-terminal - transcription regulation | 10 | 10 | Y |
| Beta-APP | PF03494 | Beta-amyloid peptide (beta-APP) | 77 | 51 | N |
| Beta-Casp | PF10996 | Beta-Casp domain | 1 | 1 | N |
| Beta-lactamase | PF00144 | Beta-lactamase | 1 | 1 | N |
| Beta-lactamase2 | PF13354 | Beta-lactamase enzyme family | 2 | 2 | N |
| BH3 | PF15285 | Beclin-1 BH3 domain, Bcl-2-interacting | 11 | 3 | N |
| BH4 | PF02180 | Bcl-2 homology region 4 | 39 | 4 | N |
| bHLH-MYC_N | PF14215 | bHLH-MYC and R2R3-MYB transcription factors N-terminal | 4 | 6 | N |
| BID | PF06393 | BH3 interacting domain (BID) | 7 | 2 | N |
| Big_8 | PF17961 | Bacterial Ig domain | 11 | 11 | N |
| Big_9 | PF17963 | Bacterial Ig domain | 3 | 3 | N |
| Biopterin_H | PF00351 | Biopterin-dependent aromatic amino acid hydroxylase | 2 | 2 | N |
| BIR | PF00653 | Inhibitor of Apoptosis domain | 46 | 46 | Y |
| BK_channel_a | PF03493 | Calcium-activated BK potassium channel alpha subunit | 0 | 2 | N |
| BNIP3 | PF06553 | BNIP3 | 0 | 3 | N |
| Bombesin | PF02044 | Bombesin-like peptide | 11 | 1 | N |
| BOP1NT | PF08145 | BOP1NT (NUC169) domain | 6 | 1 | N |
| Branch | PF02485 | Core-2/I-Branching enzyme | 8 | 8 | N |
| BRCA2 | PF00634 | BRCA2 repeat | 2 | 1 | N |
| BRCT | PF00533 | BRCA1 C Terminus (BRCT) domain | 26 | 24 | Y |
| BRCT_2 | PF16589 | BRCT domain, a BRCA1 C-terminus domain | 19 | 10 | N |
| BRCT_3 | PF18428 | BRCA1 C Terminus (BRCT) domain | 2 | 2 | N |
| Brix | PF04427 | Brix domain | 5 | 2 | N |
| Brme1 | PF15710 | Break repair meiotic recombinase recruitment factor 1 | 0 | 1 | N |
| BrnT_toxin | PF04365 | Ribonuclease toxin, BrnT, of type II toxin-antitoxin system | 0 | 1 | N |
| BRO1 | PF03097 | BRO1-like domain | 19 | 13 | Y |
| Bromodomain | PF00439 | Bromodomain | 143 | 126 | Y |
| BRX | PF08381 | Transcription factor regulating root and shoot growth via Pin3 | 2 | 2 | N |
| BTB | PF00651 | BTB/POZ domain | 41 | 11 | N |
| BTB_2 | PF02214 | BTB/POZ domain | 4 | 2 | N |
| BTD | PF09270 | Beta-trefoil DNA-binding domain | 8 | 8 | N |
| Bud13 | PF09736 | Pre-mRNA-splicing factor of RES complex | 1 | 1 | N |
| bZIP_1 | PF00170 | bZIP transcription factor | 4 | 6 | N |
| bZIP_2 | PF07716 | Basic region leucine zipper | 10 | 39 | N |
| C1-set | PF07654 | Immunoglobulin C1-set domain | 2084 | 127 | N |
| C2 | PF00168 | C2 domain | 3 | 4 | N |
| Ca_chan_IQ | PF08763 | Voltage gated calcium channel IQ domain | 11 | 1 | N |
| Cadherin_4 | PF17803 | Bacterial cadherin-like domain | 1 | 1 | N |
| CAF1C_H4-bd | PF12265 | Histone-binding protein RBBP4 or subunit C of CAF1 complex | 22 | 23 | N |
| CagS | PF16707 | Cag pathogenicity island protein S of Helicobacter pylori | 1 | 1 | N |
| CagX | PF03524 | Conjugal transfer protein | 2 | 5 | N |
| Calc_CGRP_IAPP | PF00214 | Calcitonin / CGRP / IAPP family | 19 | 15 | N |
| Calici_coat | PF00915 | Calicivirus coat protein | 5 | 1 | N |
| CaMBD | PF02888 | Calmodulin binding domain | 1 | 1 | N |
| Candida_ALS_N | PF11766 | Cell-wall agglutinin N-terminal ligand-sugar binding | 4 | 3 | N |
| CAP_GLY | PF01302 | CAP-Gly domain | 5 | 5 | Y |
| CAP18_C | PF12153 | LPS binding domain of CAP18 (C terminal) | 12 | 6 | N |
| Capsid_NCLDV | PF04451 | Large eukaryotic DNA virus major capsid protein | 2 | 2 | N |
| Carb_anhydrase | PF00194 | Eukaryotic-type carbonic anhydrase | 4 | 4 | N |
| Carb_kinase | PF01256 | Carbohydrate kinase | 21 | 1 | N |
| CAS_C | PF12026 | Crk-Associated Substrate C-terminal domain | 3 | 1 | N |
| Cation_ATPase_C | PF00689 | Cation transporting ATPase, C-terminus | 4 | 5 | N |
| Cation_ATPase_N | PF00690 | Cation transporter/ATPase, N-terminus | 5 | 1 | N |
| CATSPERB | PF15149 | Cation channel sperm-associated protein subunit beta protein family | 1 | 1 | N |
| CBFD_NFYB_HMF | PF00808 | Histone-like transcription factor (CBF/NF-Y) and archaeal histone | 2 | 3 | N |
| CbiA | PF01656 | CobQ/CobB/MinD/ParA nucleotide binding domain | 1 | 1 | N |
| Cbl_N | PF02262 | CBL proto-oncogene N-terminal domain 1 | 28 | 28 | N |
| Cbl_N2 | PF02761 | CBL proto-oncogene N-terminus, EF hand-like domain | 27 | 4 | N |
| Cbl_N3 | PF02762 | CBL proto-oncogene N-terminus, SH2-like domain | 28 | 28 | Y |
| CBM_14 | PF01607 | Chitin binding Peritrophin-A domain | 3 | 2 | N |
| CBM_5_12 | PF02839 | Carbohydrate binding domain | 2 | 1 | N |
| CBM32 | PF18344 | Carbohydrate binding module family 32 | 2 | 2 | N |
| CBS | PF00571 | CBS domain | 1 | 1 | N |
| CC2-LZ | PF16516 | Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator | 1 | 2 | N |
| CCDC158 | PF15921 | Coiled-coil domain-containing protein 158 | 1 | 1 | N |
| CCDC23 | PF15674 | Coiled-coil domain-containing protein 23 | 6 | 2 | N |
| CCM2_C | PF16545 | Cerebral cavernous malformation protein, harmonin-homology | 1 | 1 | N |
| CDC13_N | PF16853 | Cell division control protein 13 N-terminus | 1 | 1 | N |
| CDC37_N | PF03234 | Cdc37 N terminal kinase binding | 2 | 1 | N |
| CDC48_2 | PF02933 | Cell division protein 48 (CDC48), domain 2 | 18 | 6 | N |
| CDC48_N | PF02359 | Cell division protein 48 (CDC48), N-terminal domain | 22 | 11 | N |
| Cdc6_C | PF09079 | CDC6, C terminal winged helix domain | 1 | 1 | N |
| CdiI | PF07262 | CDI immunity protein | 1 | 1 | N |
| cEGF | PF12662 | Complement Clr-like EGF-like | 0 | 1 | N |
| Cellulase | PF00150 | Cellulase (glycosyl hydrolase family 5) | 1 | 1 | N |
| CENP-I | PF07778 | Mis6 | 3 | 4 | N |
| CENP-K | PF11802 | Centromere-associated protein K | 2 | 3 | N |
| CENP-M | PF11111 | Centromere protein M (CENP-M) | 1 | 1 | N |
| CENP-T_C | PF15511 | Centromere kinetochore component CENP-T histone fold | 3 | 1 | N |
| CFTR_R | PF14396 | Cystic fibrosis TM conductance regulator (CFTR), regulator domain | 14 | 3 | N |
| CH | PF00307 | Calponin homology (CH) domain | 7 | 5 | N |
| ChAPs | PF09295 | ChAPs (Chs5p-Arf1p-binding proteins) | 1 | 1 | N |
| CHCH | PF06747 | CHCH domain | 19 | 1 | N |
| CheR | PF01739 | CheR methyltransferase, SAM binding domain | 1 | 1 | N |
| CHIP_TPR_N | PF18391 | CHIP N-terminal tetratricopeptide repeat domain | 11 | 2 | N |
| CHIPS | PF11434 | Chemotaxis-inhibiting protein CHIPS | 1 | 1 | N |
| Chitin_bind_1 | PF00187 | Chitin recognition protein | 7 | 2 | N |
| Chloroa_b-bind | PF00504 | Chlorophyll A-B binding protein | 35 | 54 | N |
| CholecysA-Rec_N | PF09193 | Cholecystokinin A receptor, N-terminal | 7 | 1 | N |
| Choline_kinase | PF01633 | Choline/ethanolamine kinase | 1 | 1 | N |
| Chromo | PF00385 | Chromo (CHRromatin Organisation MOdifier) domain | 61 | 60 | Y |
| Chromo_shadow | PF01393 | Chromo shadow domain | 4 | 4 | N |
| CI-B14_5a | PF07347 | NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) | 14 | 12 | N |
| CID | PF04818 | CID domain | 20 | 20 | N |
| CIS_tube | PF19266 | Contractile injection system tube protein | 0 | 1 | N |
| CK_II_beta | PF01214 | Casein kinase II regulatory subunit | 3 | 1 | N |
| CKS | PF01111 | Cyclin-dependent kinase regulatory subunit | 2 | 2 | N |
| CLASP_N | PF12348 | CLASP N terminal | 2 | 2 | N |
| Clat_adaptor_s | PF01217 | Clathrin adaptor complex small chain | 17 | 5 | N |
| Clathrin_H_link | PF13838 | Clathrin-H-link | 9 | 1 | N |
| Clathrin_propel | PF01394 | Clathrin propeller repeat | 14 | 13 | N |
| Clenterotox | PF03505 | Clostridium enterotoxin | 1 | 1 | N |
| CLIP1_ZNF | PF16641 | CLIP1 zinc knuckle | 1 | 1 | N |
| Clp_N | PF02861 | Clp amino terminal domain, pathogenicity island component | 39 | 10 | N |
| CLP_protease | PF00574 | Clp protease | 36 | 25 | N |
| ClpS | PF02617 | ATP-dependent Clp protease adaptor protein ClpS | 11 | 11 | N |
| CLTH | PF10607 | CTLH/CRA C-terminal to LisH motif domain | 3 | 3 | N |
| CMAS | PF02353 | Mycolic acid cyclopropane synthetase | 1 | 1 | N |
| CN_hydrolase | PF00795 | Carbon-nitrogen hydrolase | 2 | 2 | N |
| Cna_B | PF05738 | Cna protein B-type domain | 2 | 2 | N |
| Cnd1 | PF12717 | non-SMC mitotic condensation complex subunit 1 | 5 | 4 | N |
| cNMP_binding | PF00027 | Cyclic nucleotide-binding domain | 4 | 3 | N |
| Cnn_1N | PF07989 | Centrosomin N-terminal motif 1 | 1 | 4 | N |
| CNOT1_TTP_bind | PF16417 | CCR4-NOT transcription complex subunit 1 TTP binding domain | 1 | 1 | N |
| CNOT11 | PF10155 | CCR4-NOT transcription complex subunit 11 | 0 | 1 | N |
| COBRA1 | PF06209 | Cofactor of BRCA1 (COBRA1) | 1 | 1 | N |
| Cohesin_HEAT | PF12765 | HEAT repeat associated with sister chromatid cohesion | 4 | 1 | N |
| Cohesin_load | PF10345 | Cohesin loading factor | 2 | 1 | N |
| Collagen | PF01391 | Collagen triple helix repeat (20 copies) | 58 | 53 | N |
| Collagen_bind | PF05737 | Collagen binding domain | 1 | 1 | N |
| Collar | PF07484 | Phage Tail Collar Domain | 1 | 1 | N |
| COMP | PF11598 | Cartilage oligomeric matrix protein | 1 | 1 | N |
| Complex1_30kDa | PF00329 | Respiratory-chain NADH dehydrogenase, 30 Kd subunit | 26 | 2 | N |
| Complex1_49kDa | PF00346 | Respiratory-chain NADH dehydrogenase, 49 Kd subunit | 26 | 17 | N |
| Complex1_51K | PF01512 | Respiratory-chain NADH dehydrogenase 51 Kd subunit | 26 | 57 | N |
| Complex1_LYR | PF05347 | Complex 1 protein (LYR family) | 17 | 4 | N |
| ComR_TPR | PF18710 | ComR tetratricopeptide | 8 | 8 | N |
| CorC_HlyC | PF03471 | Transporter associated domain | 1 | 1 | N |
| Cortex-I_coil | PF09304 | Cortexillin I, coiled coil | 1 | 1 | N |
| Couple_hipA | PF13657 | HipA N-terminal domain | 1 | 1 | N |
| CoV_E | PF02723 | Coronavirus small envelope protein E | 10 | 1 | N |
| CoV_nucleocap | PF00937 | Coronavirus nucleocapsid | 20 | 2 | N |
| CoV_peptidase | PF08715 | Coronavirus papain-like peptidase | 4 | 4 | N |
| CoV_S2 | PF01601 | Coronavirus spike glycoprotein S2 | 49 | 8 | N |
| COX1 | PF00115 | Cytochrome C and Quinol oxidase polypeptide I | 10 | 100 | N |
| COX2 | PF00116 | Cytochrome C oxidase subunit II, periplasmic domain | 9 | 49 | N |
| COX2_TM | PF02790 | Cytochrome C oxidase subunit II, transmembrane domain | 8 | 17 | N |
| COX2-transmemb | PF09125 | Cytochrome C oxidase subunit II, transmembrane | 0 | 35 | N |
| COX3 | PF00510 | Cytochrome c oxidase subunit III | 6 | 60 | N |
| COX4 | PF02936 | Cytochrome c oxidase subunit IV | 4 | 51 | N |
| COX5A | PF02284 | Cytochrome c oxidase subunit Va | 3 | 3 | N |
| COX6B | PF02297 | Cytochrome oxidase c subunit VIb | 7 | 1 | N |
| COX6C | PF02937 | Cytochrome c oxidase subunit VIc | 3 | 16 | N |
| COX7a | PF02238 | Cytochrome c oxidase subunit VII | 4 | 14 | N |
| COX7C | PF02935 | Cytochrome c oxidase subunit VIIc | 4 | 51 | N |
| CP12 | PF02672 | CP12 domain | 3 | 1 | N |
| Cpn60_TCP1 | PF00118 | TCP-1/cpn60 chaperonin family | 2 | 3 | N |
| CPSF_A | PF03178 | CPSF A subunit region | 16 | 11 | N |
| Creatinase_N | PF01321 | Creatinase/Prolidase N-terminal domain | 4 | 4 | N |
| Creb_binding | PF09030 | Creb binding | 0 | 6 | N |
| CRF | PF00473 | Corticotropin-releasing factor family | 6 | 1 | N |
| CRISPR_Cas2 | PF09827 | CRISPR associated protein Cas2 | 2 | 1 | N |
| CRM1_C | PF08767 | CRM1 C terminal | 31 | 1 | N |
| CRM1_repeat_3 | PF18787 | CRM1 / Exportin repeat 3 | 32 | 32 | N |
| CRPV_capsid | PF08762 | CRPV capsid protein like | 6 | 8 | N |
| Crystallin | PF00525 | Alpha crystallin A chain, N terminal | 5 | 1 | N |
| CsgG | PF03783 | Curli production assembly/transport component CsgG | 1 | 1 | N |
| Csm1 | PF12539 | Chromosome segregation protein Csm1/Pcs1 | 3 | 5 | N |
| Csm1_N | PF18504 | Csm1 N-terminal domain | 0 | 1 | N |
| Ctf8 | PF09696 | Ctf8 | 2 | 5 | N |
| CtIP_N | PF10482 | Tumour-suppressor protein CtIP N-terminal domain | 0 | 1 | N |
| CUB | PF00431 | CUB domain | 3 | 2 | N |
| Cullin | PF00888 | Cullin family | 8 | 1 | N |
| Cullin_binding | PF03556 | Cullin binding | 6 | 6 | N |
| Cu-oxidase_2 | PF07731 | Multicopper oxidase | 2 | 1 | N |
| Cu-oxidase_3 | PF07732 | Multicopper oxidase | 2 | 2 | N |
| Cupin_2 | PF07883 | Cupin domain | 2 | 2 | N |
| Cupin_4 | PF08007 | Cupin superfamily protein | 4 | 6 | N |
| Cupin_8 | PF13621 | Cupin-like domain | 28 | 28 | N |
| Curlin_rpt | PF07012 | Curlin associated repeat | 4 | 1 | N |
| CXCR4_N | PF12109 | CXCR4 Chemokine receptor N terminal | 1 | 2 | N |
| Cyanophycin_syn | PF18921 | Cyanophycin synthase-like N-terminal domain | 6 | 2 | N |
| Cyclin_C | PF02984 | Cyclin, C-terminal domain | 27 | 1 | N |
| Cyclin_D1_bind | PF12014 | Cyclin D1 binding domain | 1 | 1 | N |
| Cyclin_N | PF00134 | Cyclin, N-terminal domain | 31 | 28 | N |
| Cyclotide | PF03784 | Cyclotide family | 47 | 7 | N |
| CyRPA | PF18638 | Cysteine-Rich Protective Antigen 6 bladed domain | 1 | 1 | N |
| Cys_knot | PF00007 | Cystine-knot domain | 1 | 1 | N |
| Cyt_bd_oxida_I | PF01654 | Cytochrome bd terminal oxidase subunit I | 3 | 3 | N |
| Cyt_c_ox_IV | PF12270 | Cytochrome c oxidase subunit IV | 1 | 1 | N |
| Cytochrom_B_C | PF00032 | Cytochrome b(C-terminal)/b6/petD | 31 | 4 | N |
| Cytochrom_B559 | PF00283 | Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits | 75 | 90 | N |
| Cytochrom_B559a | PF00284 | Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit | 76 | 98 | N |
| Cytochrom_B562 | PF07361 | Cytochrome b562 | 23 | 1 | N |
| Cytochrom_C1 | PF02167 | Cytochrome C1 family | 12 | 4 | N |
| Cytochrom_C550 | PF14495 | Cytochrome c-550 domain | 63 | 66 | N |
| Cytochrome_B | PF00033 | Cytochrome b/b6/petB | 29 | 20 | N |
| Cytochrome_CBB3 | PF13442 | Cytochrome C oxidase, cbb3-type, subunit III | 7 | 2 | N |
| DAC | PF02457 | DisA bacterial checkpoint controller nucleotide-binding | 1 | 1 | N |
| Dala_Dala_lig_C | PF07478 | D-ala D-ala ligase C-terminus | 2 | 1 | N |
| Dala_Dala_lig_N | PF01820 | D-ala D-ala ligase N-terminus | 2 | 2 | N |
| DAP10 | PF07213 | DAP10 membrane protein | 0 | 4 | N |
| DAP3 | PF10236 | Mitochondrial ribosomal death-associated protein 3 | 22 | 1 | N |
| Daxx | PF03344 | Daxx N-terminal Rassf1C-interacting domain | 3 | 2 | N |
| Dcc1 | PF09724 | Sister chromatid cohesion protein Dcc1 | 2 | 5 | N |
| DCD | PF06559 | 2'-deoxycytidine 5'-triphosphate deaminase (DCD) | 1 | 1 | N |
| DCP1 | PF06058 | Dcp1-like decapping family | 4 | 8 | N |
| DCP2 | PF05026 | Dcp2, box A domain | 3 | 4 | N |
| DCX | PF03607 | Doublecortin | 1 | 1 | N |
| DEAD | PF00270 | DEAD/DEAH box helicase | 13 | 4 | N |
| DED | PF01335 | Death effector domain | 3 | 2 | N |
| Defensin_1 | PF00323 | Mammalian defensin | 23 | 15 | N |
| Defensin_2 | PF01097 | Arthropod defensin | 1 | 2 | N |
| Defensin_beta | PF00711 | Beta defensin | 1 | 10 | N |
| Desulfoferrod_N | PF06397 | Desulfoferrodoxin, N-terminal domain | 0 | 4 | N |
| DHC_N1 | PF08385 | Dynein heavy chain, N-terminal region 1 | 3 | 2 | N |
| DHR-2 | PF06920 | Dock homology region 2 | 1 | 1 | N |
| DIM1 | PF02966 | Mitosis protein DIM1 | 0 | 1 | N |
| Dip | PF17679 | gp37/Dip protein | 1 | 1 | N |
| DIRP | PF06584 | DIRP | 0 | 1 | N |
| DivIC | PF04977 | Septum formation initiator | 1 | 1 | N |
| DivIVA | PF05103 | DivIVA protein | 3 | 3 | N |
| DLIC | PF05783 | Dynein light intermediate chain (DLIC) | 5 | 1 | N |
| DNA_gyraseB_C | PF00986 | DNA gyrase B subunit, carboxyl terminus | 1 | 1 | N |
| DNA_ligase_A_N | PF04675 | DNA ligase N terminus | 3 | 3 | N |
| DNA_methylase | PF00145 | C-5 cytosine-specific DNA methylase | 2 | 3 | N |
| DNA_pack_C | PF02499 | Probable DNA packing protein, C-terminus | 1 | 1 | N |
| DNA_photolyase | PF00875 | DNA photolyase | 3 | 1 | N |
| DNA_pol_A | PF00476 | DNA polymerase family A | 1 | 1 | N |
| DNA_pol_B | PF00136 | DNA polymerase family B | 2 | 4 | N |
| DNA_pol_B_exo1 | PF03104 | DNA polymerase family B, exonuclease domain | 1 | 3 | N |
| DNA_pol_E_B | PF04042 | DNA polymerase alpha/epsilon subunit B | 1 | 1 | N |
| DNA_pol3_beta | PF00712 | DNA polymerase III beta subunit, N-terminal domain | 44 | 3 | N |
| DNA_pol3_beta_2 | PF02767 | DNA polymerase III beta subunit, central domain | 44 | 44 | N |
| DNA_pol3_beta_3 | PF02768 | DNA polymerase III beta subunit, C-terminal domain | 44 | 44 | N |
| DNA_pol3_chi | PF04364 | DNA polymerase III chi subunit, HolC | 1 | 1 | N |
| DNA_pol3_gamma3 | PF12169 | DNA polymerase III subunits gamma and tau domain III | 1 | 1 | N |
| DNA_PPF | PF02916 | DNA polymerase processivity factor | 2 | 2 | N |
| DNA_topoisoIV | PF00521 | DNA gyrase/topoisomerase IV, subunit A | 2 | 1 | N |
| DnaB | PF00772 | DnaB-like helicase N terminal domain | 1 | 1 | N |
| DnaJ | PF00226 | DnaJ domain | 6 | 2 | N |
| DnaJ_C | PF01556 | DnaJ C terminal domain | 4 | 5 | N |
| DNAPKcs_CC5 | PF19704 | DNA-PKcs, CC5 | 1 | 1 | N |
| DNApol3-delta_C | PF09115 | DNA polymerase III, delta subunit, C terminal | 1 | 1 | N |
| dNK | PF01712 | Deoxynucleoside kinase | 3 | 57 | N |
| DNMT1-RFD | PF12047 | Cytosine specific DNA methyltransferase replication foci domain | 1 | 2 | N |
| DotD | PF16816 | DotD protein | 7 | 7 | N |
| DotU | PF09850 | Type VI secretion system protein DotU | 1 | 1 | N |
| DP | PF08781 | Transcription factor DP | 0 | 1 | N |
| DP-EP | PF08985 | DP-EP family | 6 | 1 | N |
| Dpp_8_9_N | PF19520 | Dipeptidyl peptidase 8 and 9 N-terminal | 5 | 5 | N |
| DPPIV_N | PF00930 | Dipeptidyl peptidase IV (DPP IV) N-terminal region | 13 | 12 | N |
| DPPIV_rep | PF18811 | Dipeptidyl peptidase IV (DPP IV) low complexity region | 6 | 2 | N |
| Dpy19 | PF10034 | Q-cell neuroblast polarisation | 2 | 2 | N |
| Dpy-30 | PF05186 | Dpy-30 motif | 6 | 3 | N |
| DREV | PF05219 | DREV methyltransferase | 5 | 5 | N |
| Drf_FH3 | PF06367 | Diaphanous FH3 Domain | 2 | 2 | N |
| Drf_GBD | PF06371 | Diaphanous GTPase-binding Domain | 2 | 2 | N |
| DSBA | PF01323 | DSBA-like thioredoxin domain | 5 | 5 | N |
| DsbB | PF02600 | Disulfide bond formation protein DsbB | 1 | 1 | N |
| DSPc | PF00782 | Dual specificity phosphatase, catalytic domain | 8 | 5 | N |
| DSPn | PF14671 | Dual specificity protein phosphatase, N-terminal half | 5 | 5 | N |
| DUF1039 | PF06287 | Protein of unknown function (DUF1039) | 0 | 1 | N |
| DUF1077 | PF06417 | Protein of unknown function (DUF1077) | 3 | 3 | N |
| DUF1241 | PF06840 | Protein of unknown function (DUF1241) | 4 | 5 | N |
| DUF1323 | PF07037 | Putative transcription regulator (DUF1323) | 0 | 1 | N |
| DUF1325 | PF07039 | SGF29 tudor-like domain | 8 | 8 | N |
| DUF1681 | PF07933 | Protein of unknown function (DUF1681) | 2 | 1 | N |
| DUF1778 | PF08681 | Protein of unknown function (DUF1778) | 0 | 1 | N |
| DUF1897 | PF09005 | Domain of unknown function (DUF1897) | 1 | 1 | N |
| DUF1968 | PF09291 | Domain of unknown function (DUF1968) | 210 | 1 | N |
| DUF2121 | PF09894 | Uncharacterized protein conserved in archaea (DUF2121) | 1 | 1 | N |
| DUF2312 | PF10073 | Uncharacterized protein conserved in bacteria (DUF2312) | 2 | 5 | N |
| DUF2383 | PF09537 | Domain of unknown function (DUF2383) | 0 | 3 | N |
| DUF257 | PF03192 | Pyrococcus protein of unknown function, DUF257 | 1 | 1 | N |
| DUF2778 | PF10908 | Protein of unknown function (DUF2778) | 3 | 3 | N |
| DUF3152 | PF11350 | Protein of unknown function (DUF3152) | 5 | 5 | N |
| DUF3215 | PF11503 | Protein of unknown function (DUF3215) | 0 | 1 | N |
| DUF3361 | PF11841 | Domain of unknown function (DUF3361) | 1 | 1 | N |
| DUF3381 | PF11861 | Domain of unknown function (DUF3381) | 3 | 1 | N |
| DUF3385 | PF11865 | Domain of unknown function (DUF3385) | 0 | 1 | N |
| DUF3458_C | PF17432 | Domain of unknown function (DUF3458_C) ARM repeats | 1 | 1 | N |
| DUF382 | PF04037 | Domain of unknown function (DUF382) | 1 | 1 | N |
| DUF4379 | PF14311 | Probable Zinc-ribbon domain | 6 | 1 | N |
| DUF4441 | PF14536 | Domain of unknown function (DUF4441) | 1 | 1 | N |
| DUF4461 | PF14688 | Domain of unknown function (DUF4461) | 3 | 3 | N |
| DUF4927 | PF16279 | Domain of unknown function (DUF4927) | 133 | 7 | N |
| DUF4951 | PF16309 | Domian of unknown function (DUF4951) | 1 | 1 | N |
| DUF5089 | PF17002 | Domain of unknown function (DUF5089) | 1 | 5 | N |
| DUF5455 | PF17537 | Family of unknown function (DUF5455) | 0 | 1 | N |
| DUF5517 | PF17639 | Family of unknown function (DUF5517) | 0 | 2 | N |
| DUF5595 | PF18077 | Domain of unknown function (DUF5595) | 1 | 1 | N |
| DUF5604 | PF18300 | Domain of unknown function (DUF5604) | 6 | 1 | N |
| DUF5838 | PF19156 | Family of unknown function (DUF5838) | 3 | 3 | N |
| DUF5908 | PF19265 | Family of unknown function (DUF5908) | 0 | 1 | N |
| DUF592 | PF04574 | Protein of unknown function (DUF592) | 3 | 1 | N |
| DUF5950 | PF19375 | Family of unknown function (DUF5950) | 2 | 2 | N |
| DUF5973 | PF19398 | Family of unknown function (DUF5973) | 7 | 2 | N |
| DUF5979 | PF19407 | Domain of unknown function (DUF5979) | 2 | 2 | N |
| DUF692 | PF05114 | Protein of unknown function (DUF692) | 2 | 2 | N |
| DUF903 | PF06004 | Bacterial protein of unknown function (DUF903) | 1 | 1 | N |
| dUTPase | PF00692 | dUTPase | 3 | 3 | N |
| Dynamin_M | PF01031 | Dynamin central region | 1 | 1 | N |
| Dynein_light | PF01221 | Dynein light chain type 1 | 27 | 26 | Y |
| E1_dh | PF00676 | Dehydrogenase E1 component | 3 | 3 | N |
| E1-E2_ATPase | PF00122 | E1-E2 ATPase | 24 | 20 | N |
| E2F_CC-MB | PF16421 | E2F transcription factor CC-MB domain | 0 | 1 | N |
| EABR | PF12180 | TSG101 and ALIX binding domain of CEP55 | 4 | 4 | N |
| EB1 | PF03271 | EB1-like C-terminal motif | 4 | 4 | N |
| EB1_binding | PF05937 | EB-1 Binding Domain | 4 | 1 | N |
| Ebola_NP | PF05505 | Ebola nucleoprotein | 7 | 3 | N |
| ECH_2 | PF16113 | Enoyl-CoA hydratase/isomerase | 6 | 3 | N |
| Ectatomin | PF06457 | Ectatomin | 0 | 1 | N |
| EFG_C | PF00679 | Elongation factor G C-terminus | 73 | 2 | N |
| EFG_III | PF14492 | Elongation Factor G, domain III | 69 | 5 | N |
| EFG_IV | PF03764 | Elongation factor G, domain IV | 67 | 7 | N |
| EF-hand_1 | PF00036 | EF hand | 27 | 35 | Y |
| EF-hand_14 | PF17959 | EF-hand domain | 1 | 1 | N |
| EF-hand_2 | PF09068 | EF hand | 1 | 1 | N |
| EF-hand_3 | PF09069 | EF-hand | 1 | 1 | N |
| EF-hand_4 | PF12763 | Cytoskeletal-regulatory complex EF hand | 7 | 6 | N |
| EF-hand_5 | PF13202 | EF hand | 2 | 2 | N |
| EF-hand_6 | PF13405 | EF-hand domain | 3 | 4 | N |
| EF-hand_7 | PF13499 | EF-hand domain pair | 166 | 166 | Y |
| EF-hand_8 | PF13833 | EF-hand domain pair | 10 | 11 | Y |
| EFhand_Ca_insen | PF08726 | Ca2+ insensitive EF hand | 2 | 2 | N |
| EFP_N | PF08207 | Elongation factor P (EF-P) KOW-like domain | 8 | 1 | N |
| eIF2_C | PF09173 | Initiation factor eIF2 gamma, C terminal | 20 | 3 | N |
| eIF2A | PF08662 | Eukaryotic translation initiation factor eIF2A | 11 | 1 | N |
| eIF-3c_N | PF05470 | Eukaryotic translation initiation factor 3 subunit 8 N-terminus | 13 | 2 | N |
| eIF3g | PF12353 | Eukaryotic translation initiation factor 3 subunit G | 11 | 1 | N |
| EIID-AGA | PF03613 | PTS system mannose/fructose/sorbose family IID component | 0 | 3 | N |
| EII-Sor | PF03609 | PTS system sorbose-specific iic component | 0 | 3 | N |
| ELMO_CED12 | PF04727 | ELMO/CED-12 family | 1 | 1 | N |
| EMC1_C | PF07774 | ER membrane protein complex subunit 1, C-terminal | 4 | 1 | N |
| EMC3_TMCO1 | PF01956 | Integral membrane protein EMC3/TMCO1-like | 5 | 2 | N |
| EMC6 | PF07019 | EMC6 | 6 | 2 | N |
| EMP24_GP25L | PF01105 | emp24/gp25L/p24 family/GOLD | 2 | 1 | N |
| Endothelin | PF00322 | Endothelin family | 14 | 2 | N |
| Enkurin | PF13864 | Calmodulin-binding | 0 | 1 | N |
| Enolase_C | PF00113 | Enolase, C-terminal TIM barrel domain | 4 | 3 | N |
| Enolase_N | PF03952 | Enolase, N-terminal domain | 5 | 3 | N |
| EnY2 | PF10163 | Transcription factor e(y)2 | 2 | 3 | N |
| EphA2_TM | PF14575 | Ephrin type-A receptor 2 transmembrane domain | 2 | 3 | N |
| Ephrin_lbd | PF01404 | Ephrin receptor ligand binding domain | 13 | 13 | N |
| EpoR_lig-bind | PF09067 | Erythropoietin receptor, ligand binding | 2 | 2 | N |
| ER | PF01133 | Enhancer of rudimentary | 0 | 2 | N |
| ER_lumen_recept | PF00810 | ER lumen protein retaining receptor | 5 | 5 | N |
| ERAP1_C | PF11838 | ERAP1-like C-terminal domain | 15 | 11 | N |
| ERCC3_RAD25_C | PF16203 | ERCC3/RAD25/XPB C-terminal helicase | 9 | 8 | N |
| eRF1_2 | PF03464 | eRF1 domain 2 | 20 | 7 | N |
| ERM | PF00769 | Ezrin/radixin/moesin family | 3 | 1 | N |
| ERp29 | PF07749 | Endoplasmic reticulum protein ERp29, C-terminal domain | 0 | 2 | N |
| EspG | PF06872 | EspG protein | 1 | 1 | N |
| ESSS | PF10183 | ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) | 6 | 12 | N |
| EST1 | PF10374 | Telomerase activating protein Est1 | 1 | 1 | N |
| EST1_DNA_bind | PF10373 | Est1 DNA/RNA binding domain | 1 | 1 | N |
| ETC_C1_NDUFA4 | PF04800 | ETC complex I subunit conserved region | 24 | 54 | N |
| Ets | PF00178 | Ets-domain | 2 | 2 | N |
| Ets1_N_flank | PF19525 | Ets1 N-terminal flanking region of Ets domain | 2 | 2 | N |
| ExbD | PF02472 | Biopolymer transport protein ExbD/TolR | 2 | 1 | N |
| Exo_endo_phos | PF03372 | Endonuclease/Exonuclease/phosphatase family | 7 | 4 | N |
| Exo70 | PF03081 | Exo70 exocyst complex subunit | 2 | 2 | N |
| Exonuc_X-T_C | PF08411 | Exonuclease C-terminal | 1 | 1 | N |
| Exportin-5 | PF19273 | Exportin-5 family | 2 | 2 | N |
| EZH2_N | PF18601 | EZH2 N-terminal domain | 4 | 3 | N |
| EzrA | PF06160 | Septation ring formation regulator, EzrA | 0 | 2 | N |
| F_actin_cap_B | PF01115 | F-actin capping protein, beta subunit | 16 | 10 | N |
| F1F0-ATPsyn_F | PF10791 | Mitochondrial F1-F0 ATP synthase subunit F of fungi | 1 | 7 | N |
| F5_F8_type_C | PF00754 | F5/8 type C domain | 10 | 8 | N |
| F-actin_cap_A | PF01267 | F-actin capping protein alpha subunit | 21 | 6 | N |
| FAD_binding_4 | PF01565 | FAD binding domain | 2 | 1 | N |
| FAD_binding_7 | PF03441 | FAD binding domain of DNA photolyase | 3 | 3 | N |
| FAD_binding_9 | PF08021 | Siderophore-interacting FAD-binding domain | 1 | 1 | N |
| FAM181 | PF15238 | FAM181 | 3 | 2 | N |
| Fanconi_A_N | PF15865 | Fanconi anaemia group A protein N terminus | 0 | 3 | N |
| Fasciclin | PF02469 | Fasciclin domain | 4 | 2 | N |
| FAT | PF02259 | FAT domain | 4 | 3 | N |
| FATC | PF02260 | FATC domain | 2 | 1 | N |
| FBXL18_C | PF19729 | F-box/LRR-repeat protein 18 C-terminal | 8 | 7 | N |
| Fe_dep_repress | PF01325 | Iron dependent repressor, N-terminal DNA binding domain | 0 | 2 | N |
| FemAB | PF02388 | FemAB family | 7 | 7 | N |
| FeoB_N | PF02421 | Ferrous iron transport protein B | 1 | 1 | N |
| Fer2_3 | PF13085 | 2Fe-2S iron-sulfur cluster binding domain | 0 | 1 | N |
| Fer4_17 | PF13534 | 4Fe-4S dicluster domain | 2 | 1 | N |
| Fer4_24 | PF18109 | Ferredoxin I 4Fe-4S cluster domain | 0 | 1 | N |
| Fer4_8 | PF13183 | 4Fe-4S dicluster domain | 0 | 1 | N |
| FERM_C | PF09380 | FERM C-terminal PH-like domain | 14 | 13 | Y |
| FERM_F1 | PF18379 | FERM F1 ubiquitin-like domain | 0 | 2 | N |
| FERM_F2 | PF18377 | FERM F2 acyl-CoA binding protein-like domain | 0 | 2 | N |
| FERM_M | PF00373 | FERM central domain | 24 | 13 | N |
| FERM_N | PF09379 | FERM N-terminal domain | 14 | 7 | N |
| Ferritin | PF00210 | Ferritin-like domain | 1 | 4 | N |
| FGE-sulfatase | PF03781 | Sulfatase-modifying factor enzyme 1 | 13 | 13 | N |
| FHA | PF00498 | FHA domain | 31 | 31 | Y |
| FHA_2 | PF17913 | FHA domain | 3 | 3 | N |
| Fib_alpha | PF08702 | Fibrinogen alpha/beta chain family | 26 | 3 | N |
| Fibrinogen_C | PF00147 | Fibrinogen beta and gamma chains, C-terminal globular domain | 26 | 26 | N |
| Fibritin_C | PF07921 | Fibritin C-terminal region | 8 | 5 | N |
| Fic | PF02661 | Fic/DOC family | 2 | 1 | N |
| Filament | PF00038 | Intermediate filament protein | 0 | 1 | N |
| Filamin | PF00630 | Filamin/ABP280 repeat | 8 | 10 | N |
| Filo_VP35 | PF02097 | Filoviridae VP35 | 4 | 1 | N |
| Fimbrial | PF00419 | Fimbrial protein | 16 | 10 | N |
| FimH_man-bind | PF09160 | FimH, mannose binding | 10 | 9 | N |
| Fip1 | PF05182 | Fip1 motif | 0 | 1 | N |
| Fis1_TPR_N | PF14852 | Fis1 N-terminal tetratricopeptide repeat | 0 | 1 | N |
| FKBP_C | PF00254 | FKBP-type peptidyl-prolyl cis-trans isomerase | 21 | 17 | N |
| Flavi_glycoprot | PF00869 | Flavivirus glycoprotein, central and dimerisation domains | 8 | 1 | N |
| Flavi_NS2B | PF01002 | Flavivirus non-structural protein NS2B | 24 | 22 | N |
| Flavi_propep | PF01570 | Flavivirus polyprotein propeptide | 1 | 1 | N |
| Flavoprotein | PF02441 | Flavoprotein | 1 | 1 | N |
| Flg_bb_rod | PF00460 | Flagella basal body rod protein | 4 | 4 | N |
| Flg_bbr_C | PF06429 | Flagellar basal body rod FlgEFG protein C-terminal | 4 | 4 | N |
| FliG_N | PF14842 | FliG N-terminal domain | 0 | 1 | N |
| FliMN_C | PF01052 | Type III flagellar switch regulator (C-ring) FliN C-term | 1 | 1 | N |
| FliT | PF05400 | Flagellar protein FliT | 1 | 1 | N |
| Flo11 | PF10182 | Flo11 domain | 1 | 1 | N |
| Flu_B_M2 | PF04772 | Influenza B matrix protein 2 (BM2) | 0 | 3 | N |
| Flu_M2 | PF00599 | Influenza Matrix protein (M2) | 32 | 25 | N |
| Flu_NP | PF00506 | Influenza virus nucleoprotein | 33 | 5 | N |
| Flu_PA | PF00603 | Influenza RNA-dependent RNA polymerase subunit PA | 20 | 11 | N |
| Flu_PB1 | PF00602 | Influenza RNA-dependent RNA polymerase subunit PB1 | 14 | 3 | N |
| Flu_PB2 | PF00604 | Influenza RNA-dependent RNA polymerase subunit PB2 | 12 | 3 | N |
| FmiP_Thoc5 | PF09766 | Fms-interacting protein/Thoc5 | 0 | 1 | N |
| Fn_bind | PF02986 | Fibronectin binding repeat | 3 | 2 | N |
| fn1 | PF00039 | Fibronectin type I domain | 8 | 8 | N |
| fn2 | PF00040 | Fibronectin type II domain | 1 | 1 | N |
| fn3 | PF00041 | Fibronectin type III domain | 44 | 14 | N |
| Focal_AT | PF03623 | Focal adhesion targeting region | 12 | 12 | N |
| FPN1 | PF06963 | Ferroportin1 (FPN1) | 2 | 2 | N |
| F-protein | PF00469 | Negative factor, (F-Protein) or Nef | 44 | 19 | N |
| FR47 | PF08445 | FR47-like protein | 1 | 1 | N |
| FragX_IP | PF05994 | Cytoplasmic Fragile-X interacting family | 1 | 1 | N |
| FRB_dom | PF08771 | FKBP12-rapamycin binding domain | 2 | 1 | N |
| Fringe | PF02434 | Fringe-like | 1 | 1 | N |
| FtsA | PF14450 | Cell division protein FtsA | 1 | 2 | N |
| FtsJ | PF01728 | FtsJ-like methyltransferase | 7 | 1 | N |
| FtsK_SpoIIIE | PF01580 | FtsK/SpoIIIE family | 2 | 1 | N |
| FtsQ | PF03799 | Cell division protein FtsQ | 1 | 2 | N |
| FtsX | PF02687 | FtsX-like permease family | 5 | 2 | N |
| FtsZ_C | PF12327 | FtsZ family, C-terminal domain | 1 | 1 | N |
| Fun_ATP-synt_8 | PF05933 | Fungal ATP synthase protein 8 (A6L) | 6 | 5 | N |
| Fungal_lectin | PF07938 | Fungal fucose-specific lectin | 1 | 1 | N |
| Furin-like | PF00757 | Furin-like cysteine rich region | 37 | 2 | N |
| Fusion_gly | PF00523 | Fusion glycoprotein F0 | 6 | 1 | N |
| FUT8_N_cat | PF19745 | Alpha-(1,6)-fucosyltransferase N- and catalytic domains | 2 | 2 | N |
| FXMRP1_C_core | PF12235 | Fragile X-related 1 protein core C terminal | 6 | 1 | N |
| Gag_p17 | PF00540 | gag gene protein p17 (matrix protein) | 18 | 1 | N |
| Gag_p24 | PF00607 | gag protein p24 N-terminal domain | 24 | 18 | N |
| Gag_p24_C | PF19317 | Gag protein p24 C-terminal domain | 43 | 16 | N |
| Gag_spuma | PF03276 | Spumavirus gag protein | 2 | 1 | N |
| GAIN | PF16489 | GPCR-Autoproteolysis INducing (GAIN) domain | 2 | 1 | N |
| Gal11_ABD1 | PF18535 | Gal11 activator-binding domain (ABD1) | 0 | 1 | N |
| Gal-bind_lectin | PF00337 | Galactoside-binding lectin | 2 | 2 | N |
| Gallidermin | PF02052 | Gallidermin | 3 | 1 | N |
| G-alpha | PF00503 | G-protein alpha subunit | 133 | 13 | N |
| Gamma_PGA_hydro | PF05908 | Poly-gamma-glutamate hydrolase | 1 | 1 | N |
| Gamma-thionin | PF00304 | Gamma-thionin family | 18 | 8 | N |
| GAS | PF13851 | Growth-arrest specific micro-tubule binding | 1 | 2 | N |
| GATA | PF00320 | GATA zinc finger | 1 | 4 | N |
| GBP_C | PF02841 | Guanylate-binding protein, C-terminal domain | 0 | 1 | N |
| GCP_N_terminal | PF17681 | Gamma tubulin complex component N-terminal | 1 | 4 | N |
| Gelsolin | PF00626 | Gelsolin repeat | 20 | 5 | N |
| Gemin6 | PF06372 | Gemin6 protein | 0 | 1 | N |
| Gemin7 | PF11095 | Gem-associated protein 7 (Gemin7) | 0 | 1 | N |
| Geminin | PF07412 | Geminin | 1 | 1 | N |
| GerE | PF00196 | Bacterial regulatory proteins, luxR family | 2 | 1 | N |
| GET4 | PF04190 | Golgi to ER traffic protein 4 | 1 | 1 | N |
| Get5_C | PF18514 | Get5 C-terminal domain | 0 | 1 | N |
| GFO_IDH_MocA | PF01408 | Oxidoreductase family, NAD-binding Rossmann fold | 2 | 2 | N |
| GFO_IDH_MocA_C | PF02894 | Oxidoreductase family, C-terminal alpha/beta domain | 2 | 2 | N |
| GFP | PF01353 | Green fluorescent protein | 0 | 1 | N |
| G-gamma | PF00631 | GGL domain | 24 | 1 | N |
| Gin | PF10764 | Inhibitor of sigma-G Gin | 0 | 1 | N |
| GIT_SHD | PF08518 | Spa2 homology domain (SHD) of GIT | 1 | 1 | N |
| GIT1_C | PF12205 | G protein-coupled receptor kinase-interacting protein 1 C term | 3 | 3 | N |
| GLE1 | PF07817 | GLE1-like protein | 0 | 4 | N |
| GLEYA | PF10528 | GLEYA domain | 1 | 1 | N |
| Gln-synt_C | PF00120 | Glutamine synthetase, catalytic domain | 6 | 6 | N |
| Gln-synt_N | PF03951 | Glutamine synthetase, beta-Grasp domain | 6 | 6 | N |
| Glucosaminidase | PF01832 | Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase | 1 | 1 | N |
| Glutaredoxin | PF00462 | Glutaredoxin | 3 | 2 | N |
| Glyco_hydro_1 | PF00232 | Glycosyl hydrolase family 1 | 2 | 3 | N |
| Glyco_hydro_18 | PF00704 | Glycosyl hydrolases family 18 | 18 | 18 | N |
| Glyco_hydro_20 | PF00728 | Glycosyl hydrolase family 20, catalytic domain | 1 | 1 | N |
| Glyco_hydro_30 | PF02055 | Glycosyl hydrolase family 30 TIM-barrel domain | 1 | 1 | N |
| Glyco_hydro_76 | PF03663 | Glycosyl hydrolase family 76 | 1 | 1 | N |
| Glyco_tran_28_C | PF04101 | Glycosyltransferase family 28 C-terminal domain | 4 | 3 | N |
| Glyco_trans_A_1 | PF09318 | Glycosyl transferase 1 domain A | 5 | 5 | N |
| Glyco_transf_24 | PF18404 | Glucosyltransferase 24 | 0 | 7 | N |
| Glyco_transf_28 | PF03033 | Glycosyltransferase family 28 N-terminal domain | 4 | 3 | N |
| Glyco_transf_41 | PF13844 | Glycosyl transferase family 41 | 29 | 29 | N |
| Glyco_transf_90 | PF05686 | Glycosyl transferase family 90 | 0 | 2 | N |
| Glycogen_syn | PF05693 | Glycogen synthase | 2 | 2 | N |
| Glycolytic | PF00274 | Fructose-bisphosphate aldolase class-I | 4 | 5 | N |
| Glycophorin_A | PF01102 | Glycophorin A | 3 | 3 | N |
| Glycos_trans_3N | PF02885 | Glycosyl transferase family, helical bundle domain | 2 | 2 | N |
| Glycos_transf_2 | PF00535 | Glycosyl transferase family 2 | 18 | 12 | N |
| Glycos_transf_3 | PF00591 | Glycosyl transferase family, a/b domain | 1 | 1 | N |
| GMP_PDE_delta | PF05351 | GMP-PDE, delta subunit | 9 | 9 | N |
| GNAT_C | PF18164 | GNAT-like C-terminal domain | 3 | 3 | N |
| GnRH | PF00446 | Gonadotropin-releasing hormone | 3 | 1 | N |
| GNT-I | PF03071 | GNT-I family | 1 | 1 | N |
| GntR | PF00392 | Bacterial regulatory proteins, gntR family | 1 | 2 | N |
| GOLD_2 | PF13897 | Golgi-dynamics membrane-trafficking | 5 | 5 | N |
| Gp_dh_C | PF02800 | Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain | 3 | 3 | N |
| Gp_dh_N | PF00044 | Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain | 3 | 3 | N |
| GP120 | PF00516 | Envelope glycoprotein GP120 | 95 | 22 | N |
| Gp23 | PF07068 | Major capsid protein Gp23 | 1 | 1 | N |
| GP41 | PF00517 | Retroviral envelope protein | 103 | 34 | N |
| gp45-slide_C | PF09116 | gp45 sliding clamp, C terminal | 2 | 2 | N |
| G-patch_2 | PF12656 | G-patch domain | 0 | 1 | N |
| GPS | PF01825 | GPCR proteolysis site, GPS, motif | 3 | 1 | N |
| GramPos_pilinD1 | PF16555 | Gram-positive pilin subunit D1, N-terminal domain | 1 | 1 | N |
| GRAS | PF03514 | GRAS domain family | 1 | 2 | N |
| GRASP55_65 | PF04495 | GRASP55/65 PDZ-like domain | 4 | 4 | N |
| GRIM-19 | PF06212 | GRIM-19 protein | 6 | 1 | N |
| GSDH | PF07995 | Glucose / Sorbosone dehydrogenase | 1 | 1 | N |
| GSHPx | PF00255 | Glutathione peroxidase | 3 | 3 | N |
| GST_C | PF00043 | Glutathione S-transferase, C-terminal domain | 3 | 2 | N |
| GST_C_3 | PF14497 | Glutathione S-transferase, C-terminal domain | 1 | 1 | N |
| GST_N | PF02798 | Glutathione S-transferase, N-terminal domain | 5 | 5 | N |
| GTP_EFTU | PF00009 | Elongation factor Tu GTP binding domain | 153 | 15 | N |
| GTP_EFTU_D2 | PF03144 | Elongation factor Tu domain 2 | 118 | 10 | N |
| GTP_EFTU_D3 | PF03143 | Elongation factor Tu C-terminal domain | 28 | 2 | N |
| Guanylate_kin | PF00625 | Guanylate kinase | 20 | 17 | N |
| GYF | PF02213 | GYF domain | 4 | 4 | N |
| HA2 | PF04408 | Helicase associated domain (HA2) | 3 | 5 | N |
| Hairy_orange | PF07527 | Hairy Orange | 0 | 1 | N |
| Harakiri | PF15196 | Activator of apoptosis harakiri | 2 | 1 | N |
| Haspin_kinase | PF12330 | Haspin like kinase domain | 4 | 3 | N |
| HAT | PF02184 | HAT (Half-A-TPR) repeat | 2 | 1 | N |
| HAT_KAT11 | PF08214 | Histone acetylation protein | 1 | 1 | N |
| Hat1_N | PF10394 | Histone acetyl transferase HAT1 N-terminus | 3 | 3 | N |
| HAV_VP | PF12944 | Hepatitis A virus viral protein VP | 0 | 1 | N |
| HCV_NS1 | PF01560 | Hepatitis C virus non-structural protein E2/NS1 | 27 | 1 | N |
| HCV_NS4a | PF01006 | Hepatitis C virus non-structural protein NS4a | 51 | 25 | N |
| HEAT | PF02985 | HEAT repeat | 10 | 4 | N |
| HEAT_2 | PF13646 | HEAT repeats | 39 | 11 | N |
| HEAT_EZ | PF13513 | HEAT-like repeat | 20 | 24 | N |
| Helicase_C | PF00271 | Helicase conserved C-terminal domain | 29 | 14 | N |
| Helicase_C_3 | PF13625 | Helicase conserved C-terminal domain | 9 | 8 | N |
| Hemagglutinin | PF00509 | Haemagglutinin | 44 | 8 | N |
| Hemopexin | PF00045 | Hemopexin | 3 | 3 | N |
| Hepatitis_core | PF00906 | Hepatitis core antigen | 11 | 5 | N |
| Herpes_glycoH_C | PF17488 | Herpesvirus glycoprotein H C-terminal domain | 0 | 3 | N |
| Herpes_glycop_H | PF02489 | Herpesvirus glycoprotein H main domain | 1 | 3 | N |
| Herpes_PAP | PF03325 | Herpesvirus polymerase accessory protein | 1 | 1 | N |
| Herpes_TAF50 | PF03326 | Herpesvirus transcription activation factor (transactivator) | 1 | 1 | N |
| Herpes_UL49_2 | PF04823 | Herpesvirus UL49 tegument protein | 1 | 1 | N |
| Herpes_UL6 | PF01763 | Herpesvirus UL6 like | 1 | 1 | N |
| HetR_C | PF18460 | Heterocyst differentiation regulator C-terminal Hood domain | 1 | 1 | N |
| Hex_IIIa | PF02455 | Hexon-associated protein (IIIa) | 6 | 1 | N |
| Hexapep | PF00132 | Bacterial transferase hexapeptide (six repeats) | 21 | 6 | N |
| HHH_5 | PF14520 | Helix-hairpin-helix domain | 3 | 1 | N |
| HipA_C | PF07804 | HipA-like C-terminal domain | 1 | 1 | N |
| HipN | PF18253 | Hsp70-interacting protein N N-terminal domain | 0 | 1 | N |
| HIRA_B | PF09453 | HIRA B motif | 1 | 1 | N |
| His_Phos_1 | PF00300 | Histidine phosphatase superfamily (branch 1) | 1 | 1 | N |
| Hist_deacetyl | PF00850 | Histone deacetylase domain | 26 | 26 | N |
| Histone | PF00125 | Core histone H2A/H2B/H3/H4 | 454 | 37 | N |
| Histone_H2A_C | PF16211 | C-terminus of histone H2A | 25 | 16 | N |
| Histone_HNS | PF00816 | H-NS histone family | 0 | 2 | N |
| HIT | PF01230 | HIT domain | 1 | 1 | N |
| Hit1_C | PF18268 | Hit1 C-terminal | 0 | 1 | N |
| HLH | PF00010 | Helix-loop-helix DNA-binding domain | 1 | 4 | N |
| HMGL-like | PF00682 | HMGL-like | 1 | 1 | N |
| HNF-1_N | PF04814 | Hepatocyte nuclear factor 1 (HNF-1), N terminus | 0 | 4 | N |
| HOIP-UBA | PF16678 | HOIP UBA domain pair | 1 | 1 | N |
| Hom_end_hint | PF05203 | Hom_end-associated Hint | 1 | 3 | N |
| Homeodomain | PF00046 | Homeodomain | 16 | 2 | N |
| Homez | PF11569 | Homeodomain leucine-zipper encoding, Homez | 1 | 1 | N |
| HOOK_N | PF19047 | HOOK domain | 1 | 1 | N |
| HORMA | PF02301 | HORMA domain | 24 | 25 | Y |
| Hormone_2 | PF00123 | Peptide hormone | 40 | 2 | N |
| Hormone_3 | PF00159 | Pancreatic hormone peptide | 9 | 1 | N |
| Hormone_4 | PF00220 | Neurohypophysial hormones, N-terminal Domain | 7 | 1 | N |
| Hormone_5 | PF00184 | Neurohypophysial hormones, C-terminal Domain | 2 | 2 | N |
| Hormone_recep | PF00104 | Ligand-binding domain of nuclear hormone receptor | 881 | 835 | N |
| HRM | PF02793 | Hormone receptor domain | 40 | 98 | Y |
| HSA | PF07529 | HSA | 3 | 1 | N |
| HSBP1 | PF06825 | Heat shock factor binding protein 1 | 1 | 1 | N |
| HSM3_C | PF18794 | DNA mismatch repair protein HSM3, C terminal domain | 1 | 1 | N |
| HSP20 | PF00011 | Hsp20/alpha crystallin family | 16 | 11 | N |
| HSP70 | PF00012 | Hsp70 protein | 45 | 46 | Y |
| HTH_11 | PF08279 | HTH domain | 0 | 1 | N |
| HTH_3 | PF01381 | Helix-turn-helix | 11 | 3 | N |
| HTH_8 | PF02954 | Bacterial regulatory protein, Fis family | 1 | 1 | N |
| HTH_9 | PF08221 | RNA polymerase III subunit RPC82 helix-turn-helix domain | 0 | 1 | N |
| HTH_Crp_2 | PF13545 | Crp-like helix-turn-helix domain | 1 | 1 | N |
| I_LWEQ | PF01608 | I/LWEQ domain | 2 | 1 | N |
| IATP | PF04568 | Mitochondrial ATPase inhibitor, IATP | 7 | 1 | N |
| IBB | PF01749 | Importin beta binding domain | 82 | 1 | N |
| IBN_N | PF03810 | Importin-beta N-terminal domain | 51 | 2 | N |
| ICAP-1_inte_bdg | PF10480 | Beta-1 integrin binding protein | 2 | 2 | N |
| IF4E | PF01652 | Eukaryotic initiation factor 4E | 28 | 31 | N |
| IFNGR1 | PF07140 | Interferon gamma receptor (IFNGR1) | 0 | 2 | N |
| ig | PF00047 | Immunoglobulin domain | 30 | 14 | N |
| Ig_2 | PF13895 | Immunoglobulin domain | 16 | 5 | N |
| Ig_3 | PF13927 | Immunoglobulin domain | 11 | 5 | N |
| Ig_6 | PF18452 | Immunoglobulin domain | 1 | 1 | N |
| IKKbetaNEMObind | PF12179 | I-kappa-kinase-beta NEMO binding domain | 0 | 1 | N |
| Il13Ra_Ig | PF18001 | Interleukin-13 receptor subunit alpha Ig-like domain | 1 | 1 | N |
| IL17 | PF06083 | Interleukin-17 | 6 | 6 | N |
| IL23 | PF16649 | Interleukin 23 subunit alpha | 1 | 1 | N |
| IL6Ra-bind | PF09240 | Interleukin-6 receptor alpha chain, binding | 1 | 1 | N |
| IL8 | PF00048 | Small cytokines (intecrine/chemokine), interleukin-8 like | 7 | 9 | N |
| Ilar_coat | PF01787 | Ilarvirus coat protein | 1 | 1 | N |
| ILEI | PF15711 | Interleukin-like EMT inducer | 2 | 2 | N |
| IMD | PF08397 | IRSp53/MIM homology domain | 1 | 1 | N |
| IMPa_N_2 | PF18650 | Immunomodulating metalloprotease N-terminal domain | 1 | 1 | N |
| ImpE | PF07024 | ImpE protein | 1 | 1 | N |
| Importin_rep_4 | PF18808 | Importin repeat | 4 | 3 | N |
| Importin_rep_5 | PF18816 | Importin repeat | 5 | 4 | N |
| Importin_rep_6 | PF18829 | Importin repeat 6 | 5 | 4 | N |
| IN_DBD_C | PF00552 | Integrase DNA binding domain | 0 | 1 | N |
| IncE | PF17627 | Inclusion membrane protein E | 6 | 4 | N |
| Inhibitor_I67 | PF11405 | Bromelain inhibitor VI | 2 | 2 | N |
| Inhibitor_I9 | PF05922 | Peptidase inhibitor I9 | 19 | 2 | N |
| Inovirus_G7P_2 | PF19978 | Tail virion protein G7P | 0 | 1 | N |
| Insulin | PF00049 | Insulin/IGF/Relaxin family | 405 | 18 | N |
| Insulin_TMD | PF17870 | Insulin receptor trans-membrane segment | 26 | 3 | N |
| Integrase_Zn | PF02022 | Integrase Zinc binding domain | 1 | 3 | N |
| Integrin_b_cyt | PF08725 | Integrin beta cytoplasmic domain | 13 | 9 | N |
| Integrin_B_tail | PF07965 | Integrin beta tail domain | 2 | 3 | N |
| Integrin_beta | PF00362 | Integrin beta chain VWA domain | 23 | 25 | N |
| INTS2 | PF14750 | Integrator complex subunit 2 | 2 | 2 | N |
| InvH | PF04741 | InvH outer membrane lipoprotein | 2 | 2 | N |
| Ion_trans | PF00520 | Ion transport protein | 32 | 16 | N |
| Ion_trans_2 | PF07885 | Ion channel | 0 | 3 | N |
| iPGM_N | PF06415 | BPG-independent PGAM N-terminus (iPGM_N) | 5 | 5 | N |
| IQ | PF00612 | IQ calmodulin-binding motif | 30 | 4 | N |
| IRF-3 | PF10401 | Interferon-regulatory factor 3 | 4 | 6 | N |
| IRK_C | PF17655 | Inward rectifier potassium channel C-terminal domain | 1 | 1 | N |
| IRS | PF02174 | PTB domain (IRS-1 type) | 15 | 16 | Y |
| Iso_dh | PF00180 | Isocitrate/isopropylmalate dehydrogenase | 2 | 1 | N |
| IspD | PF01128 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | 1 | 1 | N |
| Ist1 | PF03398 | Regulator of Vps4 activity in the MVB pathway | 1 | 1 | N |
| ITAM | PF02189 | Immunoreceptor tyrosine-based activation motif | 11 | 2 | N |
| JAB | PF01398 | JAB1/Mov34/MPN/PAD-1 ubiquitin protease | 18 | 11 | N |
| Jacalin | PF01419 | Jacalin-like lectin domain | 32 | 32 | N |
| JHD | PF17811 | Jumonji helical domain | 14 | 12 | N |
| JmjC | PF02373 | JmjC domain, hydroxylase | 46 | 40 | N |
| KaiA | PF07688 | KaiA C-terminal domain | 1 | 3 | N |
| KASH | PF10541 | Nuclear envelope localisation domain | 1 | 1 | N |
| KASH_CCD | PF14662 | Coiled-coil region of CCDC155 or KASH | 0 | 2 | N |
| Katanin_con80 | PF13925 | con80 domain of Katanin | 2 | 2 | N |
| Kazal_1 | PF00050 | Kazal-type serine protease inhibitor domain | 3 | 1 | N |
| Kazal_2 | PF07648 | Kazal-type serine protease inhibitor domain | 1 | 1 | N |
| KCNQ_channel | PF03520 | KCNQ voltage-gated potassium channel | 1 | 1 | N |
| KdpA | PF03814 | Potassium-transporting ATPase A subunit | 19 | 17 | N |
| Kelch_1 | PF01344 | Kelch motif | 49 | 49 | N |
| Kelch_3 | PF13415 | Galactose oxidase, central domain | 7 | 7 | N |
| Kelch_4 | PF13418 | Galactose oxidase, central domain | 5 | 5 | N |
| Keratin_2_head | PF16208 | Keratin type II head | 3 | 2 | N |
| ketoacyl-synt | PF00109 | Beta-ketoacyl synthase, N-terminal domain | 1 | 1 | N |
| KH_1 | PF00013 | KH domain | 4 | 1 | N |
| KH_2 | PF07650 | KH domain | 763 | 4 | N |
| KH_6 | PF15985 | KH domain | 0 | 2 | N |
| KH_8 | PF17903 | Krr1 KH1 domain | 2 | 1 | N |
| KilA-N | PF04383 | KilA-N domain | 3 | 3 | N |
| KIND | PF16474 | Kinase non-catalytic C-lobe domain | 2 | 2 | N |
| Kinesin | PF00225 | Kinesin motor domain | 2 | 2 | N |
| KIX | PF02172 | KIX domain | 7 | 10 | N |
| Knl1_RWD_C | PF18210 | Knl1 RWD C-terminal domain | 1 | 1 | N |
| KOW | PF00467 | KOW motif | 750 | 8 | N |
| Kringle | PF00051 | Kringle domain | 3 | 4 | N |
| Ku | PF02735 | Ku70/Ku80 beta-barrel domain | 7 | 2 | N |
| Ku_C | PF03730 | Ku70/Ku80 C-terminal arm | 9 | 1 | N |
| Ku_N | PF03731 | Ku70/Ku80 N-terminal alpha/beta domain | 14 | 11 | N |
| Kunitz_BPTI | PF00014 | Kunitz/Bovine pancreatic trypsin inhibitor domain | 13 | 2 | N |
| L27 | PF02828 | L27 domain | 0 | 1 | N |
| Lactamase_B | PF00753 | Metallo-beta-lactamase superfamily | 5 | 3 | N |
| Lactamase_B_6 | PF16661 | Metallo-beta-lactamase superfamily domain | 2 | 1 | N |
| Lactonase | PF10282 | Lactonase, 7-bladed beta-propeller | 5 | 3 | N |
| Laminin_EGF | PF00053 | Laminin EGF domain | 1 | 1 | N |
| LANC_like | PF05147 | Lanthionine synthetase C-like protein | 1 | 1 | N |
| Lant_dehydr_C | PF14028 | Lantibiotic biosynthesis dehydratase C-term | 1 | 2 | N |
| Lant_dehydr_N | PF04738 | Lantibiotic dehydratase, N terminus | 0 | 1 | N |
| Lantibiotic_a | PF14867 | Lantibiotic alpha | 4 | 1 | N |
| LBR_tudor | PF09465 | Lamin-B receptor of TUDOR domain | 1 | 1 | N |
| Ldl_recept_a | PF00057 | Low-density lipoprotein receptor domain class A | 3 | 1 | N |
| Ldl_recept_b | PF00058 | Low-density lipoprotein receptor repeat class B | 3 | 6 | N |
| Lebercilin | PF15619 | Ciliary protein causing Leber congenital amaurosis disease | 0 | 1 | N |
| Lectin_C | PF00059 | Lectin C-type domain | 12 | 5 | N |
| Lectin_legB | PF00139 | Legume lectin domain | 14 | 14 | N |
| LEDGF | PF11467 | Lens epithelium-derived growth factor (LEDGF) | 2 | 2 | N |
| Leu_Phe_trans | PF03588 | Leucyl/phenylalanyl-tRNA protein transferase | 2 | 2 | N |
| Leuk-A4-hydro_C | PF09127 | Leukotriene A4 hydrolase, C-terminal | 3 | 3 | N |
| Leukocidin | PF07968 | Leukocidin/Hemolysin toxin family | 2 | 2 | N |
| LHC | PF00556 | Antenna complex alpha/beta subunit | 3 | 38 | N |
| LIAS_N | PF16881 | N-terminal domain of lipoyl synthase of Radical_SAM family | 1 | 1 | N |
| LID | PF17916 | LIM interaction domain (LID) | 0 | 2 | N |
| LIM | PF00412 | LIM domain | 4 | 4 | N |
| LIN52 | PF10044 | Retinal tissue protein | 2 | 1 | N |
| LIN9_C | PF19438 | LIN9 C-terminal | 0 | 2 | N |
| Linocin_M18 | PF04454 | Encapsulating protein for peroxidase | 4 | 4 | N |
| Lipocalin | PF00061 | Lipocalin / cytosolic fatty-acid binding protein family | 3 | 3 | N |
| Lipoprotein_1 | PF00820 | Borrelia lipoprotein | 1 | 1 | N |
| LMWPc | PF01451 | Low molecular weight phosphotyrosine protein phosphatase | 3 | 1 | N |
| LMWSLP_N | PF12211 | Low molecular weight S layer protein N terminal | 0 | 2 | N |
| Lon_C | PF05362 | Lon protease (S16) C-terminal proteolytic domain | 17 | 5 | N |
| LON_substr_bdg | PF02190 | ATP-dependent protease La (LON) substrate-binding domain | 1 | 1 | N |
| LPP | PF04728 | Lipoprotein leucine-zipper | 4 | 4 | N |
| LptD_N | PF03968 | LptA/(LptD N-terminal domain) LPS transport protein | 9 | 9 | N |
| LRR_4 | PF12799 | Leucine Rich repeats (2 copies) | 12 | 9 | N |
| LRR_8 | PF13855 | Leucine rich repeat | 32 | 28 | N |
| LRRNT_2 | PF08263 | Leucine rich repeat N-terminal domain | 24 | 9 | N |
| LSDAT_euk | PF18139 | SLOG in TRPM | 11 | 11 | N |
| LSM14 | PF12701 | Scd6-like Sm domain | 1 | 1 | N |
| LUC7 | PF03194 | LUC7 N_terminus | 0 | 1 | N |
| Lys | PF00062 | C-type lysozyme/alpha-lactalbumin family | 6 | 1 | N |
| LysM | PF01476 | LysM domain | 6 | 3 | N |
| LysR_substrate | PF03466 | LysR substrate binding domain | 2 | 2 | N |
| M11L | PF11099 | Apoptosis regulator M11L like | 12 | 12 | N |
| M60-like_N | PF17291 | N-terminal domain of M60-like peptidases | 3 | 1 | N |
| MA3 | PF02847 | MA3 domain | 3 | 1 | N |
| MacB_PCD | PF12704 | MacB-like periplasmic core domain | 5 | 5 | N |
| MAD | PF05557 | Mitotic checkpoint protein | 3 | 3 | N |
| Mad3_BUB1_I | PF08311 | Mad3/BUB1 homology region 1 | 4 | 1 | N |
| Mad3_BUB1_II | PF08171 | Mad3/BUB1 homology region 2 | 1 | 1 | N |
| MAGE | PF01454 | MAGE family | 11 | 1 | N |
| MAJIN | PF15077 | Membrane-anchored junction protein | 0 | 2 | N |
| Mak10 | PF04112 | Mak10 subunit, NatC N(alpha)-terminal acetyltransferase | 2 | 2 | N |
| Malectin_like | PF12819 | Malectin-like domain | 1 | 1 | N |
| MA-Mit | PF09245 | Mycoplasma arthritidis-derived mitogen | 3 | 3 | N |
| MarR | PF01047 | MarR family | 1 | 1 | N |
| MarR_2 | PF12802 | MarR family | 1 | 1 | N |
| MAS20 | PF02064 | MAS20 protein import receptor | 8 | 8 | N |
| MatE | PF01554 | MatE | 3 | 3 | N |
| MATH | PF00917 | MATH domain | 54 | 54 | Y |
| MazE_antitoxin | PF04014 | Antidote-toxin recognition MazE, bacterial antitoxin | 1 | 1 | N |
| MBF1 | PF08523 | Multiprotein bridging factor 1 | 0 | 2 | N |
| MBOAT | PF03062 | MBOAT, membrane-bound O-acyltransferase family | 4 | 4 | N |
| MBT | PF02820 | mbt repeat | 10 | 11 | Y |
| Mcl1_mid | PF12341 | Minichromosome loss protein, Mcl1, middle region | 5 | 1 | N |
| MCM6_C | PF18263 | MCM6 C-terminal winged-helix domain | 3 | 1 | N |
| MCPVI | PF02993 | Minor capsid protein VI | 13 | 2 | N |
| Med1 | PF10744 | Mediator of RNA polymerase II transcription subunit 1 | 3 | 3 | N |
| Med14 | PF08638 | Mediator complex subunit MED14 | 4 | 1 | N |
| Med17 | PF10156 | Subunit 17 of Mediator complex | 8 | 5 | N |
| Med18 | PF09637 | Med18 protein | 7 | 1 | N |
| Med22 | PF06179 | Surfeit locus protein 5 subunit 22 of Mediator complex | 3 | 1 | N |
| Med26 | PF08711 | TFIIS helical bundle-like domain | 7 | 5 | N |
| Med28 | PF11594 | Mediator complex subunit 28 | 3 | 1 | N |
| Med31 | PF05669 | SOH1 | 7 | 3 | N |
| Med4 | PF10018 | Vitamin-D-receptor interacting Mediator subunit 4 | 7 | 2 | N |
| Med6 | PF04934 | MED6 mediator sub complex component | 8 | 4 | N |
| Med7 | PF05983 | MED7 protein | 7 | 3 | N |
| Med8 | PF10232 | Mediator of RNA polymerase II transcription complex subunit 8 | 8 | 5 | N |
| Melittin | PF01372 | Melittin | 8 | 2 | N |
| Menin | PF05053 | Menin | 5 | 5 | N |
| MerR-DNA-bind | PF09278 | MerR, DNA binding | 2 | 1 | N |
| Metalloenzyme | PF01676 | Metalloenzyme superfamily | 5 | 5 | N |
| Metallopep | PF12044 | Putative peptidase family | 2 | 2 | N |
| Metallophos | PF00149 | Calcineurin-like phosphoesterase | 34 | 37 | N |
| Metallophos_2 | PF12850 | Calcineurin-like phosphoesterase superfamily domain | 8 | 8 | N |
| Methyltrans_Mon | PF14314 | Virus-capping methyltransferase | 0 | 1 | N |
| Methyltransf_25 | PF13649 | Methyltransferase domain | 21 | 18 | N |
| Methyltransf_31 | PF13847 | Methyltransferase domain | 1 | 1 | N |
| Methyltransf_5 | PF01795 | MraW methylase family | 3 | 2 | N |
| Methyltransf_PK | PF05891 | AdoMet dependent proline di-methyltransferase | 18 | 18 | N |
| MG1 | PF17790 | Macroglobulin domain MG1 | 2 | 2 | N |
| MG2 | PF01835 | MG2 domain | 2 | 2 | N |
| MG4 | PF17789 | Macroglobulin domain MG4 | 2 | 2 | N |
| MH2 | PF03166 | MH2 domain | 3 | 3 | N |
| MHC_I | PF00129 | Class I Histocompatibility antigen, domains alpha 1 and 2 | 1206 | 1194 | N |
| MHC_I_3 | PF16497 | MHC-I family domain | 3 | 2 | N |
| MHC_II_alpha | PF00993 | Class II histocompatibility antigen, alpha domain | 187 | 178 | N |
| MHC_II_beta | PF00969 | Class II histocompatibility antigen, beta domain | 179 | 177 | N |
| MIB_HERC2 | PF06701 | Mib_herc2 | 2 | 2 | N |
| MIF4G | PF02854 | MIF4G domain | 5 | 3 | N |
| MIF4G_like | PF09088 | MIF4G like | 1 | 2 | N |
| MIF4G_like_2 | PF09090 | MIF4G like | 1 | 2 | N |
| MIT | PF04212 | MIT (microtubule interacting and transport) domain | 18 | 14 | N |
| MitMem_reg | PF13012 | Maintenance of mitochondrial structure and function | 17 | 5 | N |
| Mlh1_C | PF16413 | DNA mismatch repair protein Mlh1 C-terminus | 2 | 2 | N |
| Mltc_N | PF11873 | Membrane-bound lytic murein transglycosylase C, N-terminal domain | 1 | 1 | N |
| MmlI | PF09448 | Methylmuconolactone methyl-isomerase | 1 | 1 | N |
| MMR_HSR1 | PF01926 | 50S ribosome-binding GTPase | 10 | 1 | N |
| MMS1_N | PF10433 | Mono-functional DNA-alkylating methyl methanesulfonate N-term | 14 | 11 | N |
| Mo25 | PF08569 | Mo25-like | 3 | 3 | N |
| Mob1_phocein | PF03637 | Mob1/phocein family | 6 | 6 | N |
| MobC | PF05713 | Bacterial mobilisation protein (MobC) | 0 | 2 | N |
| MoCF_biosynth | PF00994 | Probable molybdopterin binding domain | 10 | 10 | N |
| Mod_r | PF07200 | Modifier of rudimentary (Mod(r)) protein | 1 | 1 | N |
| MoeA_C | PF03454 | MoeA C-terminal region (domain IV) | 11 | 11 | N |
| MoeA_N | PF03453 | MoeA N-terminal region (domain I and II) | 10 | 10 | N |
| Molybdopterin | PF00384 | Molybdopterin oxidoreductase | 24 | 52 | N |
| Mononeg_RNA_pol | PF00946 | Mononegavirales RNA dependent RNA polymerase | 3 | 1 | N |
| Monooxygenase_B | PF04744 | Monooxygenase subunit B protein | 5 | 1 | N |
| Morc6_S5 | PF17942 | Morc6 ribosomal protein S5 domain 2-like | 1 | 2 | N |
| MORN | PF02493 | MORN repeat | 4 | 4 | N |
| MotA_ExbB | PF01618 | MotA/TolQ/ExbB proton channel family | 2 | 2 | N |
| Motile_Sperm | PF00635 | MSP (Major sperm protein) domain | 6 | 5 | N |
| MOZ_SAS | PF01853 | MOZ/SAS family | 3 | 9 | N |
| MRAP | PF15183 | Melanocortin-2 receptor accessory protein family | 1 | 1 | N |
| MRG | PF05712 | MRG | 1 | 2 | N |
| mRNA_cap_C | PF03919 | mRNA capping enzyme, C-terminal domain | 4 | 1 | N |
| mRNA_cap_enzyme | PF01331 | mRNA capping enzyme, catalytic domain | 4 | 3 | N |
| mRNA_decap_C | PF16741 | mRNA-decapping enzyme C-terminus | 0 | 1 | N |
| mRNA_triPase | PF02940 | mRNA capping enzyme, beta chain | 1 | 1 | N |
| MRP-L27 | PF09809 | Mitochondrial ribosomal protein L27 | 18 | 3 | N |
| MRP-L28 | PF09812 | Mitochondrial ribosomal protein L28 | 31 | 1 | N |
| MRP-L47 | PF06984 | Mitochondrial 39-S ribosomal protein L47 (MRP-L47) | 41 | 6 | N |
| MRP-S28 | PF10213 | Mitochondrial ribosomal subunit protein | 26 | 13 | N |
| MRP-S31 | PF15433 | Mitochondrial 28S ribosomal protein S31 | 18 | 11 | N |
| MRP-S33 | PF08293 | Mitochondrial ribosomal subunit S27 | 21 | 11 | N |
| MSA_2 | PF00985 | Merozoite Surface Antigen 2 (MSA-2) family | 1 | 1 | N |
| MscL | PF01741 | Large-conductance mechanosensitive channel, MscL | 1 | 1 | N |
| MSP | PF01716 | Manganese-stabilising protein / photosystem II polypeptide | 52 | 1 | N |
| Mst1_SARAH | PF11629 | C terminal SARAH domain of Mst1 | 7 | 1 | N |
| Mt_ATP-synt_B | PF05405 | Mitochondrial ATP synthase B chain precursor (ATP-synt_B) | 9 | 40 | N |
| Mt_ATP-synt_D | PF05873 | ATP synthase D chain, mitochondrial (ATP5H) | 15 | 6 | N |
| Mtf2_C | PF14061 | Polycomb-like MTF2 factor 2 | 1 | 1 | N |
| MtrA | PF04208 | Tetrahydromethanopterin S-methyltransferase, subunit A | 1 | 1 | N |
| MTS | PF05175 | Methyltransferase small domain | 1 | 2 | N |
| Mucin15 | PF15672 | Cell-membrane associated Mucin15 | 0 | 4 | N |
| muHD | PF10291 | Muniscin C-terminal mu homology domain | 3 | 3 | N |
| MUN | PF06292 | MUN domain | 1 | 1 | N |
| Mur_ligase_M | PF08245 | Mur ligase middle domain | 8 | 4 | N |
| Muramidase | PF11860 | N-acetylmuramidase | 1 | 1 | N |
| MxiM | PF11441 | Pilot protein MxiM | 1 | 1 | N |
| Myb_DNA-binding | PF00249 | Myb-like DNA-binding domain | 38 | 2 | N |
| Myc-LZ | PF02344 | Myc leucine zipper domain | 7 | 2 | N |
| Myosin_N | PF02736 | Myosin N-terminal SH3-like domain | 1 | 1 | N |
| Myosin-VI_CBD | PF16521 | Myosin VI cargo binding domain | 1 | 1 | N |
| N_Asn_amidohyd | PF14736 | Protein N-terminal asparagine amidohydrolase | 2 | 2 | N |
| N2227 | PF07942 | N2227-like protein | 2 | 1 | N |
| Na_K-ATPase | PF00287 | Sodium / potassium ATPase beta chain | 2 | 2 | N |
| Nab2 | PF11517 | Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) | 1 | 1 | N |
| Nab6_mRNP_bdg | PF10567 | RNA-recognition motif | 9 | 8 | N |
| NAD_binding_1 | PF00175 | Oxidoreductase NAD-binding domain | 1 | 1 | N |
| NAD_binding_10 | PF13460 | NAD(P)H-binding | 4 | 1 | N |
| NAD_binding_11 | PF14833 | NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase | 3 | 3 | N |
| NADH_dehy_S2_C | PF06444 | NADH dehydrogenase subunit 2 C-terminus | 3 | 15 | N |
| NADH5_C | PF06455 | NADH dehydrogenase subunit 5 C-terminus | 10 | 19 | N |
| NADHdh | PF00146 | NADH dehydrogenase | 16 | 5 | N |
| NADHdh_A3 | PF14987 | NADH dehydrogenase 1 alpha subcomplex subunit 3 | 5 | 1 | N |
| NAGidase | PF07555 | beta-N-acetylglucosaminidase | 13 | 11 | N |
| NAP | PF00956 | Nucleosome assembly protein (NAP) | 2 | 1 | N |
| NapD | PF03927 | NapD protein | 0 | 1 | N |
| NARP1 | PF12569 | NMDA receptor-regulated protein 1 | 7 | 3 | N |
| NAT_N | PF18082 | N-acyltransferase N-terminal domain | 3 | 3 | N |
| NatB_MDM20 | PF09797 | N-acetyltransferase B complex (NatB) non catalytic subunit | 6 | 1 | N |
| NB-ARC | PF00931 | NB-ARC domain | 4 | 4 | N |
| Nckap1 | PF09735 | Membrane-associated apoptosis protein | 1 | 1 | N |
| NDNF_C | PF19433 | Neuron-derived Neurotrophic Factor C-terminal | 1 | 1 | N |
| NDUF_B12 | PF08122 | NADH-ubiquinone oxidoreductase B12 subunit family | 6 | 7 | N |
| NDUF_B5 | PF09781 | NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit | 2 | 5 | N |
| NDUF_B7 | PF05676 | NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) | 9 | 7 | N |
| NDUF_B8 | PF05821 | NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) | 2 | 2 | N |
| NDUF_C2 | PF06374 | NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) | 9 | 86 | N |
| NDUFB10 | PF10249 | NADH-ubiquinone oxidoreductase subunit 10 | 4 | 5 | N |
| Ndufs5 | PF10200 | NADH:ubiquinone oxidoreductase, NDUFS5-15kDa | 8 | 6 | N |
| Neisseria_PilC | PF05567 | Neisseria PilC beta-propeller domain | 1 | 1 | N |
| NEMO | PF11577 | NF-kappa-B essential modulator NEMO | 0 | 1 | N |
| Neprosin | PF03080 | Neprosin | 1 | 1 | N |
| Neur_chan_LBD | PF02931 | Neurotransmitter-gated ion-channel ligand binding domain | 28 | 17 | N |
| Neur_chan_memb | PF02932 | Neurotransmitter-gated ion-channel transmembrane region | 8 | 1 | N |
| Nha1_C | PF08619 | Alkali metal cation/H+ antiporter Nha1 C terminus | 1 | 1 | N |
| NHR2 | PF08788 | NHR2 domain like | 1 | 1 | N |
| Nic96 | PF04097 | Nup93/Nic96 | 5 | 5 | N |
| NIF | PF03031 | NLI interacting factor-like phosphatase | 6 | 6 | N |
| Nitrophorin | PF02087 | Nitrophorin | 1 | 1 | N |
| NMDAR2_C | PF10565 | N-methyl D-aspartate receptor 2B3 C-terminus | 10 | 6 | N |
| NmrA | PF05368 | NmrA-like family | 5 | 3 | N |
| NMT | PF01233 | Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain | 21 | 21 | N |
| NMT_C | PF02799 | Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain | 21 | 21 | N |
| NNMT_PNMT_TEMT | PF01234 | NNMT/PNMT/TEMT family | 4 | 4 | N |
| NO_synthase | PF02898 | Nitric oxide synthase, oxygenase domain | 1 | 1 | N |
| NOG1 | PF06858 | Nucleolar GTP-binding protein 1 (NOG1) | 5 | 1 | N |
| Not1 | PF04054 | CCR4-Not complex component, Not1 | 1 | 1 | N |
| NPL4 | PF05021 | NPL4 family | 2 | 2 | N |
| NRIP1_repr_2 | PF15688 | Nuclear receptor-interacting protein 1 repression 2 | 9 | 1 | N |
| Nsp1_C | PF05064 | Nsp1-like C-terminal region | 6 | 2 | N |
| Nt_Gln_amidase | PF09764 | N-terminal glutamine amidase | 1 | 1 | N |
| NTF2 | PF02136 | Nuclear transport factor 2 (NTF2) domain | 10 | 11 | N |
| NUC194 | PF08163 | NUC194 domain | 1 | 1 | N |
| Nucleopor_Nup85 | PF07575 | Nup85 Nucleoporin | 6 | 1 | N |
| Nucleoporin_C | PF03177 | Non-repetitive/WGA-negative nucleoporin C-terminal | 7 | 6 | N |
| Nucleoporin_FG2 | PF15967 | Nucleoporin FG repeated region | 1 | 3 | N |
| Nucleoporin_N | PF08801 | Nup133 N terminal like | 6 | 6 | N |
| Nucleoporin2 | PF04096 | Nucleoporin autopeptidase | 1 | 3 | N |
| NUDIX | PF00293 | NUDIX domain | 21 | 3 | N |
| Nup188 | PF10487 | Nucleoporin subcomplex protein binding to Pom34 | 5 | 5 | N |
| Nup188_C | PF18378 | Nuclear pore protein NUP188 C-terminal domain | 5 | 1 | N |
| Nup192 | PF11894 | Nuclear pore complex scaffold, nucleoporins 186/192/205 | 6 | 8 | N |
| Nup54 | PF13874 | Nucleoporin complex subunit 54 | 6 | 6 | N |
| Nup54_C | PF18437 | Nup54 C-terminal interacting domain | 0 | 5 | N |
| NYD-SP28_assoc | PF14775 | Sperm tail C-terminal domain | 0 | 1 | N |
| OB_NTP_bind | PF07717 | Oligonucleotide/oligosaccharide-binding (OB)-fold | 3 | 5 | N |
| OCRE | PF17780 | OCRE domain | 3 | 1 | N |
| O-FucT | PF10250 | GDP-fucose protein O-fucosyltransferase | 5 | 5 | N |
| Omp85 | PF01103 | Omp85 superfamily domain | 14 | 11 | N |
| OmpA | PF00691 | OmpA family | 9 | 9 | N |
| Omptin | PF01278 | Omptin family | 1 | 1 | N |
| Op_neuropeptide | PF08035 | Opioids neuropeptide | 0 | 1 | N |
| ORC_WH_C | PF18137 | Origin recognition complex winged helix C-terminal | 1 | 1 | N |
| ORC2 | PF04084 | Origin recognition complex subunit 2 | 1 | 2 | N |
| ORC3_N | PF07034 | Origin recognition complex (ORC) subunit 3 N-terminus | 1 | 1 | N |
| ORC5_C | PF14630 | Origin recognition complex (ORC) subunit 5 C-terminus | 1 | 2 | N |
| ORMDL | PF04061 | ORMDL family | 0 | 4 | N |
| OSCP | PF00213 | ATP synthase delta (OSCP) subunit | 10 | 6 | N |
| Osmo_CC | PF08946 | Osmosensory transporter coiled coil | 0 | 1 | N |
| OSR1_C | PF12202 | Oxidative-stress-responsive kinase 1 C-terminal domain | 2 | 2 | N |
| OST3_OST6 | PF04756 | OST3 / OST6 family, transporter family | 10 | 8 | N |
| OTU | PF02338 | OTU-like cysteine protease | 1 | 1 | N |
| Oxidored_q2 | PF00420 | NADH-ubiquinone/plastoquinone oxidoreductase chain 4L | 12 | 15 | N |
| Oxidored_q3 | PF00499 | NADH-ubiquinone/plastoquinone oxidoreductase chain 6 | 10 | 7 | N |
| Oxidored_q4 | PF00507 | NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 | 7 | 1 | N |
| Oxidored_q5_N | PF01059 | NADH-ubiquinone oxidoreductase chain 4, amino terminus | 9 | 18 | N |
| Oxidored_q6 | PF01058 | NADH ubiquinone oxidoreductase, 20 Kd subunit | 26 | 1 | N |
| P_proprotein | PF01483 | Proprotein convertase P-domain | 20 | 1 | N |
| P34-Arc | PF04045 | Arp2/3 complex, 34 kD subunit p34-Arc | 4 | 1 | N |
| P3A | PF08727 | Poliovirus 3A protein like | 2 | 2 | N |
| p450 | PF00067 | Cytochrome P450 | 6 | 3 | N |
| P53 | PF00870 | P53 DNA-binding domain | 12 | 1 | N |
| P53_tetramer | PF07710 | P53 tetramerisation motif | 0 | 21 | N |
| P66_CC | PF16563 | Coiled-coil and interaction region of P66A and P66B with MBD2 | 0 | 1 | N |
| PA | PF02225 | PA domain | 5 | 5 | N |
| PABP | PF00658 | Poly-adenylate binding protein, unique domain | 16 | 16 | N |
| Pacifastin_I | PF05375 | Pacifastin inhibitor (LCMII) | 0 | 4 | N |
| PAD | PF03068 | Protein-arginine deiminase (PAD) | 5 | 4 | N |
| PAE | PF03283 | Pectinacetylesterase | 2 | 2 | N |
| PAH | PF02671 | Paired amphipathic helix repeat | 6 | 8 | N |
| PA-IIL | PF07472 | Fucose-binding lectin II (PA-IIL) | 30 | 30 | N |
| PA-IL | PF07828 | PA-IL-like protein | 4 | 3 | N |
| PALB2_WD40 | PF16756 | Partner and localizer of BRCA2 WD40 domain | 6 | 1 | N |
| PALP | PF00291 | Pyridoxal-phosphate dependent enzyme | 19 | 19 | N |
| PAM2 | PF07145 | Ataxin-2 C-terminal region | 10 | 1 | N |
| PAN_1 | PF00024 | PAN domain | 4 | 5 | N |
| PAN_2 | PF08276 | PAN-like domain | 0 | 1 | N |
| PAP_RNA-bind | PF04926 | Poly(A) polymerase predicted RNA binding domain | 1 | 1 | N |
| PAP1 | PF08601 | Transcription factor PAP1 | 1 | 1 | N |
| ParA | PF10609 | NUBPL iron-transfer P-loop NTPase | 1 | 1 | N |
| Paramyx_P_V_C | PF03210 | Paramyxovirus P/V phosphoprotein C-terminal | 1 | 3 | N |
| Paramyxo_ncap | PF00973 | Paramyxovirus nucleocapsid protein | 15 | 4 | N |
| Parathyroid | PF01279 | Parathyroid hormone family | 7 | 1 | N |
| ParE_toxin | PF05016 | ParE toxin of type II toxin-antitoxin system, parDE | 2 | 1 | N |
| PARP | PF00644 | Poly(ADP-ribose) polymerase catalytic domain | 0 | 1 | N |
| PAS_11 | PF14598 | PAS domain | 2 | 5 | N |
| PAS_3 | PF08447 | PAS fold | 0 | 1 | N |
| PAT1 | PF09770 | Topoisomerase II-associated protein PAT1 | 3 | 3 | N |
| Paxillin | PF03535 | Paxillin family | 7 | 1 | N |
| PBP_dimer | PF03717 | Penicillin-binding Protein dimerisation domain | 4 | 3 | N |
| PC_rep | PF01851 | Proteasome/cyclosome repeat | 7 | 1 | N |
| PC4 | PF02229 | Transcriptional Coactivator p15 (PC4) | 1 | 1 | N |
| PCI | PF01399 | PCI domain | 18 | 1 | N |
| PCMT | PF01135 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) | 1 | 1 | N |
| PCNA_C | PF02747 | Proliferating cell nuclear antigen, C-terminal domain | 44 | 45 | N |
| PCNA_N | PF00705 | Proliferating cell nuclear antigen, N-terminal domain | 44 | 45 | N |
| PCRF | PF03462 | PCRF domain | 27 | 1 | N |
| PCuAC | PF04314 | Copper chaperone PCu(A)C | 1 | 1 | N |
| PD40 | PF07676 | WD40-like Beta Propeller Repeat | 6 | 2 | N |
| PDEase_I | PF00233 | 3'5'-cyclic nucleotide phosphodiesterase | 3 | 3 | N |
| PDGF | PF00341 | PDGF/VEGF domain | 8 | 9 | N |
| PDZ | PF00595 | PDZ domain | 218 | 209 | Y |
| PDZ_2 | PF13180 | PDZ domain | 37 | 35 | Y |
| PDZ_3 | PF17815 | PDZ domain | 1 | 1 | N |
| PDZ_5 | PF17817 | PDZ domain | 1 | 1 | N |
| PDZ_6 | PF17820 | PDZ domain | 42 | 30 | N |
| Pectate_lyase_2 | PF06917 | Periplasmic pectate lyase | 1 | 1 | N |
| Pectate_lyase22 | PF14583 | Oligogalacturonate lyase | 4 | 1 | N |
| PemK_toxin | PF02452 | PemK-like, MazF-like toxin of type II toxin-antitoxin system | 4 | 6 | N |
| Pep_deformylase | PF01327 | Polypeptide deformylase | 12 | 11 | N |
| Peptidase_A4 | PF01828 | Peptidase A4 family | 3 | 3 | N |
| Peptidase_A6 | PF01829 | Peptidase A6 family | 0 | 1 | N |
| Peptidase_A8 | PF01252 | Signal peptidase (SPase) II | 3 | 3 | N |
| Peptidase_C1 | PF00112 | Papain family cysteine protease | 39 | 39 | N |
| Peptidase_C10 | PF01640 | Peptidase C10 family | 1 | 1 | N |
| Peptidase_C107 | PF17222 | Viral cysteine endopeptidase C107 | 1 | 1 | N |
| Peptidase_C11 | PF03415 | Clostripain family | 3 | 3 | N |
| Peptidase_C12 | PF01088 | Ubiquitin carboxyl-terminal hydrolase, family 1 | 1 | 1 | N |
| Peptidase_C13 | PF01650 | Peptidase C13 family | 8 | 8 | N |
| Peptidase_C14 | PF00656 | Caspase domain | 181 | 181 | N |
| Peptidase_C2 | PF00648 | Calpain family cysteine protease | 4 | 4 | N |
| Peptidase_C3 | PF00548 | 3C cysteine protease (picornain 3C) | 8 | 8 | N |
| Peptidase_C30 | PF05409 | Coronavirus endopeptidase C30 | 84 | 84 | N |
| Peptidase_C37 | PF05416 | Southampton virus-type processing peptidase | 5 | 5 | N |
| Peptidase_C39 | PF03412 | Peptidase C39 family | 2 | 2 | N |
| Peptidase_C4 | PF00863 | Peptidase family C4 | 3 | 3 | N |
| Peptidase_C5 | PF00770 | Adenovirus endoprotease | 10 | 10 | N |
| Peptidase_C50 | PF03568 | Peptidase family C50 | 3 | 3 | N |
| Peptidase_M1 | PF01433 | Peptidase family M1 domain | 20 | 20 | N |
| Peptidase_M1_N | PF17900 | Peptidase M1 N-terminal domain | 20 | 20 | N |
| Peptidase_M10 | PF00413 | Matrixin | 28 | 25 | N |
| Peptidase_M13 | PF01431 | Peptidase family M13 | 1 | 1 | N |
| Peptidase_M13_N | PF05649 | Peptidase family M13 | 1 | 1 | N |
| Peptidase_M14 | PF00246 | Zinc carboxypeptidase | 4 | 5 | N |
| Peptidase_M16 | PF00675 | Insulinase (Peptidase family M16) | 39 | 35 | N |
| Peptidase_M16_C | PF05193 | Peptidase M16 inactive domain | 39 | 46 | N |
| Peptidase_M16_M | PF16187 | Middle or third domain of peptidase_M16 | 20 | 15 | N |
| Peptidase_M17 | PF00883 | Cytosol aminopeptidase family, catalytic domain | 2 | 2 | N |
| Peptidase_M2 | PF01401 | Angiotensin-converting enzyme | 11 | 11 | N |
| Peptidase_M23 | PF01551 | Peptidase family M23 | 3 | 2 | N |
| Peptidase_M24 | PF00557 | Metallopeptidase family M24 | 23 | 11 | N |
| Peptidase_M27 | PF01742 | Clostridial neurotoxin zinc protease | 20 | 17 | N |
| Peptidase_M28 | PF04389 | Peptidase family M28 | 8 | 5 | N |
| Peptidase_M3 | PF01432 | Peptidase family M3 | 3 | 3 | N |
| Peptidase_M4 | PF01447 | Thermolysin metallopeptidase, catalytic domain | 3 | 3 | N |
| Peptidase_M4_C | PF02868 | Thermolysin metallopeptidase, alpha-helical domain | 3 | 3 | N |
| Peptidase_M41 | PF01434 | Peptidase family M41 | 2 | 1 | N |
| Peptidase_M42 | PF05343 | M42 glutamyl aminopeptidase | 1 | 1 | N |
| Peptidase_M43 | PF05572 | Pregnancy-associated plasma protein-A | 2 | 2 | N |
| Peptidase_M48 | PF01435 | Peptidase family M48 | 1 | 1 | N |
| Peptidase_M49 | PF03571 | Peptidase family M49 | 8 | 8 | N |
| Peptidase_M60 | PF13402 | Peptidase M60, enhancin and enhancin-like | 3 | 2 | N |
| Peptidase_M9 | PF01752 | Collagenase | 6 | 6 | N |
| Peptidase_M9_N | PF08453 | Peptidase family M9 N-terminal | 4 | 3 | N |
| Peptidase_Prp | PF04327 | Cysteine protease Prp | 2 | 2 | N |
| Peptidase_S10 | PF00450 | Serine carboxypeptidase | 2 | 2 | N |
| Peptidase_S11 | PF00768 | D-alanyl-D-alanine carboxypeptidase | 1 | 1 | N |
| Peptidase_S21 | PF00716 | Assemblin (Peptidase family S21) | 3 | 3 | N |
| Peptidase_S26 | PF10502 | Signal peptidase, peptidase S26 | 6 | 6 | N |
| Peptidase_S29 | PF02907 | Hepatitis C virus NS3 protease | 58 | 44 | N |
| Peptidase_S3 | PF00944 | Alphavirus core protein | 0 | 1 | N |
| Peptidase_S41 | PF03572 | Peptidase family S41 | 7 | 7 | N |
| Peptidase_S46 | PF10459 | Peptidase S46 | 6 | 6 | N |
| Peptidase_S64 | PF08192 | Peptidase family S64 | 19 | 19 | N |
| Peptidase_S66 | PF02016 | LD-carboxypeptidase N-terminal domain | 1 | 1 | N |
| Peptidase_S66C | PF17676 | LD-carboxypeptidase C-terminal domain | 1 | 1 | N |
| Peptidase_S7 | PF00949 | Peptidase S7, Flavivirus NS3 serine protease | 28 | 30 | N |
| Peptidase_S8 | PF00082 | Subtilase family | 87 | 87 | N |
| Peptidase_S9 | PF00326 | Prolyl oligopeptidase family | 31 | 36 | N |
| Peptidase_S9_N | PF02897 | Prolyl oligopeptidase, N-terminal beta-propeller domain | 17 | 22 | N |
| Peripla_BP_2 | PF01497 | Periplasmic binding protein | 2 | 2 | N |
| peroxidase | PF00141 | Peroxidase | 1 | 1 | N |
| Peroxin-3 | PF04882 | Peroxin-3 | 1 | 1 | N |
| Pertussis_S2S3 | PF02918 | Pertussis toxin, subunit 2 and 3, C-terminal domain | 1 | 1 | N |
| PetG | PF02529 | Cytochrome B6-F complex subunit 5 | 17 | 18 | N |
| PetL | PF05115 | Cytochrome B6-F complex subunit VI (PetL) | 15 | 14 | N |
| PetM | PF08041 | PetM family of cytochrome b6f complex subunit 7 | 17 | 18 | N |
| Pex14_N | PF04695 | Pex14 N-terminal domain | 3 | 3 | N |
| PG_binding_1 | PF01471 | Putative peptidoglycan binding domain | 11 | 1 | N |
| PGA_cap | PF09587 | Bacterial capsule synthesis protein PGA_cap | 1 | 2 | N |
| PH | PF00169 | PH domain | 1 | 2 | N |
| PH_TFIIH | PF08567 | TFIIH p62 subunit, N-terminal domain | 16 | 9 | N |
| Phage_Capsid_P3 | PF09018 | P3 major capsid protein | 1 | 1 | N |
| Phage_Coat_B | PF05356 | Inovirus Coat protein B | 0 | 2 | N |
| Phage_coatGP8 | PF19199 | Phage major coat protein, Gp8 | 0 | 4 | N |
| Phage_F | PF02305 | Capsid protein (F protein) | 1 | 3 | N |
| Phage_GPD | PF05954 | Phage tail baseplate hub (GPD) | 0 | 1 | N |
| Phage_lysozyme | PF00959 | Phage lysozyme | 10 | 3 | N |
| Phage_prot_Gp6 | PF05133 | Phage portal protein, SPP1 Gp6-like | 1 | 1 | N |
| PHAT | PF09246 | PHAT | 2 | 2 | N |
| PHD | PF00628 | PHD-finger | 135 | 122 | Y |
| PHD_2 | PF13831 | PHD-finger | 3 | 1 | N |
| PhdYeFM_antitox | PF02604 | Antitoxin Phd_YefM, type II toxin-antitoxin system | 1 | 1 | N |
| Phospholamban | PF04272 | Phospholamban | 5 | 2 | N |
| Phospholip_A2_1 | PF00068 | Phospholipase A2 | 30 | 30 | N |
| Phosphorylase | PF00343 | Carbohydrate phosphorylase | 1 | 1 | N |
| Photo_RC | PF00124 | Photosynthetic reaction centre protein | 78 | 91 | N |
| Phycobilisome | PF00502 | Phycobilisome protein | 4 | 2 | N |
| PI3_PI4_kinase | PF00454 | Phosphatidylinositol 3- and 4-kinase | 3 | 2 | N |
| PI3Ka | PF00613 | Phosphoinositide 3-kinase family, accessory domain (PIK domain) | 1 | 1 | N |
| Pico_P1A | PF02226 | Picornavirus coat protein (VP4) | 19 | 21 | N |
| Pico_P2A | PF00947 | Picornavirus core protein 2A | 2 | 2 | N |
| PID | PF00640 | Phosphotyrosine interaction domain (PTB/PID) | 17 | 20 | Y |
| PIEZO | PF15917 | Piezo | 1 | 1 | N |
| Piezo_RRas_bdg | PF12166 | Piezo non-specific cation channel, R-Ras-binding domain | 1 | 1 | N |
| PIG-L | PF02585 | GlcNAc-PI de-N-acetylase | 1 | 1 | N |
| PIH1 | PF08190 | PIH1 N-terminal domain | 3 | 3 | N |
| Pih1_fungal_CS | PF18482 | Fungal Pih1 CS domain | 2 | 1 | N |
| Pilin_N | PF07790 | Archaeal Type IV pilin, N-terminal | 1 | 1 | N |
| PilM_2 | PF11104 | Type IV pilus assembly protein PilM; | 1 | 1 | N |
| PilO | PF04350 | Pilus assembly protein, PilO | 0 | 1 | N |
| PilS | PF08805 | PilS N terminal | 1 | 1 | N |
| PIN | PF01850 | PIN domain | 3 | 3 | N |
| Piwi | PF02171 | Piwi domain | 1 | 1 | N |
| PK_Tyr_Ser-Thr | PF07714 | Protein tyrosine and serine/threonine kinase | 38 | 31 | N |
| PKcGMP_CC | PF16808 | Coiled-coil N-terminus of cGMP-dependent protein kinase | 4 | 1 | N |
| PKHD_C | PF18331 | PKHD-type hydroxylase C-terminal domain | 1 | 1 | N |
| PKI | PF02827 | cAMP-dependent protein kinase inhibitor | 247 | 1 | N |
| pKID | PF02173 | pKID domain | 3 | 1 | N |
| Pkinase | PF00069 | Protein kinase domain | 516 | 502 | N |
| Pkinase_C | PF00433 | Protein kinase C terminal domain | 28 | 19 | N |
| PLA2_inh | PF02988 | Phospholipase A2 inhibitor | 4 | 4 | N |
| Plexin_cytopl | PF08337 | Plexin cytoplasmic RasGAP domain | 1 | 1 | N |
| Plk4_PB1 | PF18190 | Polo-like Kinase 4 Polo Box 1 | 1 | 1 | N |
| Plk4_PB2 | PF18409 | Polo-like Kinase 4 Polo Box 2 | 1 | 1 | N |
| Plug | PF07715 | TonB-dependent Receptor Plug Domain | 20 | 15 | N |
| Plug_translocon | PF10559 | Plug domain of Sec61p | 22 | 12 | N |
| Plus-3 | PF03126 | Plus-3 domain | 1 | 1 | N |
| PmbA_TldD_C | PF19289 | PmbA/TldA metallopeptidase C-terminal domain | 4 | 4 | N |
| PmbA_TldD_M | PF19290 | PmbA/TldA metallopeptidase central domain | 4 | 4 | N |
| PMC2NT | PF08066 | PMC2NT (NUC016) domain | 2 | 1 | N |
| PMT | PF02366 | Dolichyl-phosphate-mannose-protein mannosyltransferase | 1 | 1 | N |
| PMT_4TMC | PF16192 | C-terminal four TMM region of protein-O-mannosyltransferase | 1 | 1 | N |
| Pneumo_ncap | PF03246 | Pneumovirus nucleocapsid protein | 2 | 2 | N |
| Pneumo_phosprot | PF02478 | Pneumovirus phosphoprotein | 1 | 1 | N |
| Pneumovirus_M2 | PF06436 | Pneumovirus matrix protein 2 (M2) | 1 | 1 | N |
| Podoplanin | PF05808 | Podoplanin | 6 | 1 | N |
| Pol_alpha_B_N | PF08418 | DNA polymerase alpha subunit B N-terminal | 1 | 1 | N |
| POLO_box | PF00659 | POLO box duplicated region | 44 | 45 | N |
| Polyoma_coat | PF00718 | Polyomavirus coat protein | 1 | 1 | N |
| Porin_1 | PF00267 | Gram-negative porin | 9 | 5 | N |
| Porin_3 | PF01459 | Eukaryotic porin | 0 | 3 | N |
| Porin_4 | PF13609 | Gram-negative porin | 3 | 3 | N |
| POTRA | PF07244 | Surface antigen variable number repeat | 10 | 5 | N |
| POTRA_1 | PF08478 | POTRA domain, FtsQ-type | 1 | 1 | N |
| Pou | PF00157 | Pou domain - N-terminal to homeobox domain | 0 | 1 | N |
| Pox_MCEL | PF03291 | mRNA capping enzyme | 0 | 1 | N |
| Poxvirus | PF06227 | dsDNA Poxvirus | 1 | 1 | N |
| PP2C | PF00481 | Protein phosphatase 2C | 2 | 2 | N |
| PP2C_2 | PF13672 | Protein phosphatase 2C | 1 | 1 | N |
| PP-binding | PF00550 | Phosphopantetheine attachment site | 37 | 3 | N |
| PPC | PF04151 | Bacterial pre-peptidase C-terminal domain | 1 | 1 | N |
| PPE | PF00823 | PPE family | 0 | 1 | N |
| PPO1_DWL | PF12142 | Polyphenol oxidase middle domain | 3 | 2 | N |
| PPO1_KFDV | PF12143 | Protein of unknown function (DUF_B2219) | 3 | 1 | N |
| PPR | PF01535 | PPR repeat | 21 | 4 | N |
| PPR_2 | PF13041 | PPR repeat family | 28 | 6 | N |
| PPTA | PF01239 | Protein prenyltransferase alpha subunit repeat | 30 | 29 | N |
| PPV_E2_N | PF00508 | E2 (early) protein, N terminal | 1 | 1 | N |
| PqqD | PF05402 | Coenzyme PQQ synthesis protein D (PqqD) | 4 | 4 | N |
| PRC | PF05239 | PRC-barrel domain | 2 | 8 | N |
| PRC2_HTH_1 | PF18118 | Polycomb repressive complex 2 tri-helical domain | 5 | 3 | N |
| PRCH | PF03967 | Photosynthetic reaction centre, H-chain N-terminal region | 2 | 27 | N |
| Prenyltrans | PF00432 | Prenyltransferase and squalene oxidase repeat | 29 | 29 | N |
| Pre-PUA | PF17832 | Pre-PUA-like domain | 2 | 2 | N |
| Presenilin | PF01080 | Presenilin | 2 | 2 | N |
| Pre-SET | PF05033 | Pre-SET motif | 13 | 6 | N |
| PriA_3primeBD | PF17764 | 3'DNA-binding domain (3'BD) | 1 | 1 | N |
| PriA_C | PF18074 | Primosomal protein N C-terminal domain | 1 | 1 | N |
| Prion | PF00377 | Prion/Doppel alpha-helical domain | 50 | 3 | N |
| PRKG1_interact | PF15898 | cGMP-dependent protein kinase interacting domain | 0 | 1 | N |
| PRMT5 | PF05185 | PRMT5 arginine-N-methyltransferase | 4 | 2 | N |
| PRMT5_C | PF17286 | PRMT5 oligomerisation domain | 21 | 19 | N |
| PRMT5_TIM | PF17285 | PRMT5 TIM barrel domain | 5 | 3 | N |
| Pro_isomerase | PF00160 | Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD | 76 | 70 | N |
| PRO8NT | PF08082 | PRO8NT (NUC069), PrP8 N-terminal domain | 3 | 1 | N |
| PROCN | PF08083 | PROCN (NUC071) domain | 3 | 1 | N |
| Profilin | PF00235 | Profilin | 11 | 11 | N |
| Pro-NT_NN | PF07421 | Neurotensin/neuromedin N precursor | 25 | 1 | N |
| Prot_ATP_ID_OB | PF16450 | Proteasomal ATPase OB C-terminal domain | 9 | 12 | N |
| Proteasom_Rpn13 | PF04683 | Proteasome complex subunit Rpn13 ubiquitin receptor | 6 | 6 | N |
| Proteasome | PF00227 | Proteasome subunit | 71 | 63 | N |
| Proteasome_A_N | PF10584 | Proteasome subunit A N-terminal signature | 67 | 10 | N |
| Proton_antipo_C | PF01010 | NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus | 0 | 7 | N |
| Proton_antipo_M | PF00361 | Proton-conducting membrane transporter | 15 | 29 | N |
| PRP38 | PF03371 | PRP38 family | 0 | 2 | N |
| PRP8_domainIV | PF12134 | PRP8 domain IV core | 2 | 1 | N |
| PRY | PF13765 | SPRY-associated domain | 11 | 11 | N |
| PS_Dcarbxylase | PF02666 | Phosphatidylserine decarboxylase | 0 | 5 | N |
| PsaA_PsaB | PF00223 | Photosystem I psaA/psaB protein | 28 | 99 | N |
| PsaD | PF02531 | PsaD | 14 | 1 | N |
| PsaL | PF02605 | Photosystem I reaction centre subunit XI | 25 | 76 | N |
| PsaN | PF05479 | Photosystem I reaction centre subunit N (PSAN or PSI-N) | 3 | 2 | N |
| Psb28 | PF03912 | Psb28 protein | 3 | 2 | N |
| PsbH | PF00737 | Photosystem II 10 kDa phosphoprotein | 73 | 76 | N |
| PsbJ | PF01788 | PsbJ | 69 | 49 | N |
| PsbK | PF02533 | Photosystem II 4 kDa reaction centre component | 74 | 83 | N |
| PsbL | PF02419 | PsbL protein | 73 | 75 | N |
| PsbM | PF05151 | Photosystem II reaction centre M protein (PsbM) | 72 | 75 | N |
| PsbP | PF01789 | PsbP | 1 | 1 | N |
| PsbQ | PF05757 | Oxygen evolving enhancer protein 3 (PsbQ) | 6 | 4 | N |
| PsbW | PF07123 | Photosystem II reaction centre W protein (PsbW) | 11 | 6 | N |
| PsbX | PF06596 | Photosystem II reaction centre X protein (PsbX) | 73 | 39 | N |
| PsbY | PF06298 | Photosystem II protein Y (PsbY) | 35 | 18 | N |
| PseudoU_synth_1 | PF01416 | tRNA pseudouridine synthase | 2 | 2 | N |
| PSI | PF01437 | Plexin repeat | 4 | 1 | N |
| PSI_8 | PF00796 | Photosystem I reaction centre subunit VIII | 25 | 52 | N |
| PSI_integrin | PF17205 | Integrin plexin domain | 24 | 1 | N |
| PSI_PsaE | PF02427 | Photosystem I reaction centre subunit IV / PsaE | 14 | 1 | N |
| PSI_PsaF | PF02507 | Photosystem I reaction centre subunit III | 26 | 80 | N |
| PSI_PsaH | PF03244 | Photosystem I reaction centre subunit VI | 11 | 30 | N |
| PSII | PF00421 | Photosystem II protein | 77 | 94 | N |
| PSII_BNR | PF14870 | Photosynthesis system II assembly factor YCF48 | 2 | 2 | N |
| PSII_Ycf12 | PF05969 | Photosystem II complex subunit Ycf12 | 69 | 34 | N |
| PSMalpha | PF17063 | Phenol-soluble modulin alpha peptide family | 13 | 4 | N |
| PSMbeta | PF05480 | Phenol-soluble modulin beta protein | 0 | 1 | N |
| PSP | PF04046 | PSP | 1 | 1 | N |
| PTB | PF08416 | Phosphotyrosine-binding domain | 1 | 1 | N |
| PTCB-BRCT | PF12738 | twin BRCT domain | 14 | 13 | Y |
| PTPA | PF03095 | Phosphotyrosyl phosphate activator (PTPA) protein | 2 | 2 | N |
| PTR2 | PF00854 | POT family | 8 | 8 | N |
| PUA | PF01472 | PUA domain | 2 | 2 | N |
| PUB | PF09409 | PUB domain | 7 | 7 | N |
| PUB_1 | PF18486 | PNGase/UBA- or UBX-containing domain | 6 | 1 | N |
| PUF | PF00806 | Pumilio-family RNA binding repeat | 1 | 4 | N |
| PUL | PF08324 | PUL domain | 1 | 1 | N |
| PUMA | PF15826 | Bcl-2-binding component 3, p53 upregulated modulator of apoptosis | 18 | 1 | N |
| Pup_ligase | PF03136 | Pup-ligase protein | 4 | 4 | N |
| PurA | PF04845 | PurA ssDNA and RNA-binding protein | 0 | 1 | N |
| PWWP | PF00855 | PWWP domain | 11 | 11 | Y |
| PX | PF00787 | PX domain | 11 | 12 | N |
| PXT1 | PF15214 | Peroxisomal testis-specific protein 1 | 2 | 1 | N |
| Pyr_redox_2 | PF07992 | Pyridine nucleotide-disulphide oxidoreductase | 1 | 1 | N |
| QRPTase_C | PF01729 | Quinolinate phosphoribosyl transferase, C-terminal domain | 1 | 1 | N |
| QRPTase_N | PF02749 | Quinolinate phosphoribosyl transferase, N-terminal domain | 1 | 1 | N |
| Qua1 | PF16274 | Qua1 domain | 0 | 1 | N |
| RAB3GAP2_N | PF14655 | Rab3 GTPase-activating protein regulatory subunit N-terminus | 2 | 1 | N |
| Rab5-bind | PF09311 | Rabaptin-like protein | 0 | 1 | N |
| Rad1 | PF02144 | Repair protein Rad1/Rec1/Rad17 | 2 | 2 | N |
| Rad10 | PF03834 | Binding domain of DNA repair protein Ercc1 (rad10/Swi10) | 1 | 1 | N |
| Rad50_zn_hook | PF04423 | Rad50 zinc hook motif | 1 | 1 | N |
| Rad51 | PF08423 | Rad51 | 11 | 11 | N |
| Rad60-SLD | PF11976 | Ubiquitin-2 like Rad60 SUMO-like | 41 | 33 | N |
| Radial_spoke | PF04712 | Radial spokehead-like protein | 2 | 2 | N |
| Radial_spoke_3 | PF06098 | Radial spoke protein 3 | 1 | 2 | N |
| Radical_SAM | PF04055 | Radical SAM superfamily | 6 | 5 | N |
| RAG2_PHD | PF13341 | RAG2 PHD domain | 6 | 6 | N |
| RALF | PF05498 | Rapid ALkalinization Factor (RALF) | 1 | 1 | N |
| RAMP | PF04901 | Receptor activity modifying family | 5 | 12 | N |
| Ran_BP1 | PF00638 | RanBP1 domain | 33 | 1 | N |
| Rap1_C | PF11626 | TRF2-interacting telomeric protein/Rap1 - C terminal domain | 4 | 4 | N |
| RAP80_UIM | PF18282 | RAP80 N-terminal ubiquitin interaction motif | 0 | 1 | N |
| RapH_N | PF18801 | response regulator aspartate phosphatase H, N terminal | 3 | 1 | N |
| Ras | PF00071 | Ras family | 69 | 40 | N |
| RasGEF | PF00617 | RasGEF domain | 6 | 5 | N |
| RAWUL | PF16207 | RAWUL domain RING finger- and WD40-associated ubiquitin-like | 1 | 2 | N |
| RB_A | PF01858 | Retinoblastoma-associated protein A domain | 13 | 3 | N |
| RB_B | PF01857 | Retinoblastoma-associated protein B domain | 11 | 11 | N |
| Rb_C | PF08934 | Rb C-terminal domain | 15 | 4 | N |
| RbcX | PF02341 | RbcX protein | 2 | 2 | N |
| RBD-FIP | PF09457 | FIP domain | 0 | 3 | N |
| RBM39linker | PF15519 | linker between RRM2 and RRM3 domains in RBM39 protein | 3 | 3 | N |
| Rbsn | PF11464 | Rabenosyn Rab binding domain | 0 | 1 | N |
| RCC1 | PF00415 | Regulator of chromosome condensation (RCC1) repeat | 9 | 6 | N |
| Rcd1 | PF04078 | Cell differentiation family, Rcd1-like | 5 | 5 | N |
| RdRP_1 | PF00680 | Viral RNA-dependent RNA polymerase | 10 | 7 | N |
| RdRP_5 | PF07925 | Reovirus RNA-dependent RNA polymerase lambda 3 | 2 | 2 | N |
| REC114-like | PF15165 | Meiotic recombination protein REC114-like | 1 | 1 | N |
| Recep_L_domain | PF01030 | Receptor L domain | 40 | 18 | N |
| RecO_C | PF02565 | Recombination protein O C terminal | 1 | 1 | N |
| Rep_3 | PF01051 | Initiator Replication protein | 3 | 3 | N |
| Rep-A_N | PF04057 | Replication factor-A protein 1, N-terminal domain | 8 | 8 | N |
| Repressor_Mnt | PF11423 | Regulatory protein Mnt | 0 | 1 | N |
| Reprolysin | PF01421 | Reprolysin (M12B) family zinc metalloprotease | 6 | 6 | N |
| ResIII | PF04851 | Type III restriction enzyme, res subunit | 1 | 2 | N |
| Response_reg | PF00072 | Response regulator receiver domain | 13 | 13 | N |
| Retrotrans_gag | PF03732 | Retrotransposon gag protein | 5 | 5 | N |
| REV1_C | PF16727 | DNA repair protein REV1 C-terminal domain | 7 | 6 | N |
| RF-1 | PF00472 | RF-1 domain | 65 | 14 | N |
| RGS | PF00615 | Regulator of G protein signaling domain | 1 | 2 | N |
| RHH_1 | PF01402 | Ribbon-helix-helix protein, copG family | 0 | 5 | N |
| RHIM | PF12721 | RIP homotypic interaction motif | 2 | 2 | N |
| Rhodanese | PF00581 | Rhodanese-like domain | 10 | 4 | N |
| RhodobacterPufX | PF11511 | Intrinsic membrane protein PufX | 0 | 14 | N |
| RhoGAP | PF00620 | RhoGAP domain | 1 | 1 | N |
| Rhomboid | PF01694 | Rhomboid family | 25 | 25 | N |
| Rhv | PF00073 | picornavirus capsid protein | 33 | 13 | N |
| RIBIOP_C | PF04950 | 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal | 2 | 1 | N |
| Ribonuc_red_lgC | PF02867 | Ribonucleotide reductase, barrel domain | 21 | 21 | N |
| Ribonuc_red_sm | PF00268 | Ribonucleotide reductase, small chain | 1 | 1 | N |
| Ribonucleas_3_3 | PF14622 | Ribonuclease-III-like | 31 | 1 | N |
| Ribosom_S12_S23 | PF00164 | Ribosomal protein S12/S23 | 742 | 21 | N |
| Ribosomal_60s | PF00428 | 60s Acidic ribosomal protein | 101 | 1 | N |
| Ribosomal_L1 | PF00687 | Ribosomal protein L1p/L10e family | 164 | 3 | N |
| Ribosomal_L10 | PF00466 | Ribosomal protein L10 | 188 | 1 | N |
| Ribosomal_L11 | PF00298 | Ribosomal protein L11, RNA binding domain | 261 | 12 | N |
| Ribosomal_L11_N | PF03946 | Ribosomal protein L11, N-terminal domain | 222 | 7 | N |
| Ribosomal_L12 | PF00542 | Ribosomal protein L7/L12 C-terminal domain | 34 | 2 | N |
| Ribosomal_L12_N | PF16320 | Ribosomal protein L7/L12 dimerisation domain | 36 | 3 | N |
| Ribosomal_L13 | PF00572 | Ribosomal protein L13 | 544 | 1 | N |
| Ribosomal_L14 | PF00238 | Ribosomal protein L14p/L23e | 480 | 3 | N |
| Ribosomal_L15e | PF00827 | Ribosomal L15 | 267 | 2 | N |
| Ribosomal_L16 | PF00252 | Ribosomal protein L16p/L10e | 683 | 83 | N |
| Ribosomal_L17 | PF01196 | Ribosomal protein L17 | 349 | 13 | N |
| Ribosomal_L18A | PF01775 | Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A | 260 | 1 | N |
| Ribosomal_L19e | PF01280 | Ribosomal protein L19e | 265 | 2 | N |
| Ribosomal_L2 | PF00181 | Ribosomal Proteins L2, RNA binding domain | 479 | 2 | N |
| Ribosomal_L20 | PF00453 | Ribosomal protein L20 | 344 | 12 | N |
| Ribosomal_L21e | PF01157 | Ribosomal protein L21e | 169 | 2 | N |
| Ribosomal_L21p | PF00829 | Ribosomal prokaryotic L21 protein | 309 | 1 | N |
| Ribosomal_L22 | PF00237 | Ribosomal protein L22p/L17e | 691 | 128 | N |
| Ribosomal_L22e | PF01776 | Ribosomal L22e protein family | 257 | 2 | N |
| Ribosomal_L23 | PF00276 | Ribosomal protein L23 | 689 | 124 | N |
| Ribosomal_L23eN | PF03939 | Ribosomal protein L23, N-terminal domain | 261 | 1 | N |
| ribosomal_L24 | PF17136 | Ribosomal proteins 50S L24/mitochondrial 39S L24 | 416 | 12 | N |
| Ribosomal_L25p | PF01386 | Ribosomal L25p family | 353 | 1 | N |
| Ribosomal_L27 | PF01016 | Ribosomal L27 protein | 385 | 1 | N |
| Ribosomal_L27A | PF00828 | Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A | 485 | 2 | N |
| Ribosomal_L27e | PF01777 | Ribosomal L27e protein family | 164 | 2 | N |
| Ribosomal_L28 | PF00830 | Ribosomal L28 family | 368 | 9 | N |
| Ribosomal_L29 | PF00831 | Ribosomal L29 protein | 649 | 3 | N |
| Ribosomal_L3 | PF00297 | Ribosomal protein L3 | 485 | 2 | N |
| Ribosomal_L30 | PF00327 | Ribosomal protein L30p/L7e | 483 | 2 | N |
| Ribosomal_L30_N | PF08079 | Ribosomal L30 N-terminal domain | 262 | 2 | N |
| Ribosomal_L31e | PF01198 | Ribosomal protein L31e | 264 | 2 | N |
| Ribosomal_L32p | PF01783 | Ribosomal L32p protein family | 417 | 1 | N |
| Ribosomal_L34e | PF01199 | Ribosomal protein L34e | 261 | 21 | N |
| Ribosomal_L35p | PF01632 | Ribosomal protein L35 | 414 | 154 | N |
| Ribosomal_L36 | PF00444 | Ribosomal protein L36 | 250 | 3 | N |
| Ribosomal_L36e | PF01158 | Ribosomal protein L36e | 165 | 1 | N |
| Ribosomal_L37e | PF01907 | Ribosomal protein L37e | 265 | 73 | N |
| Ribosomal_L39 | PF00832 | Ribosomal L39 protein | 265 | 21 | N |
| Ribosomal_L4 | PF00573 | Ribosomal protein L4/L1 family | 693 | 140 | N |
| Ribosomal_L5 | PF00281 | Ribosomal protein L5 | 461 | 6 | N |
| Ribosomal_L5_C | PF00673 | ribosomal L5P family C-terminus | 517 | 7 | N |
| Ribosomal_L6 | PF00347 | Ribosomal protein L6 | 652 | 14 | N |
| Ribosomal_L7Ae | PF01248 | Ribosomal protein L7Ae/L30e/S12e/Gadd45 family | 205 | 5 | N |
| Ribosomal_L9_N | PF01281 | Ribosomal protein L9, N-terminal domain | 282 | 3 | N |
| Ribosomal_S10 | PF00338 | Ribosomal protein S10p/S20e | 800 | 8 | N |
| Ribosomal_S11 | PF00411 | Ribosomal protein S11 | 807 | 9 | N |
| Ribosomal_S13 | PF00416 | Ribosomal protein S13/S18 | 771 | 366 | N |
| Ribosomal_S14 | PF00253 | Ribosomal protein S14p/S29e | 591 | 1 | N |
| Ribosomal_S17 | PF00366 | Ribosomal protein S17 | 599 | 3 | N |
| Ribosomal_S19 | PF00203 | Ribosomal protein S19 | 580 | 1 | N |
| Ribosomal_S2 | PF00318 | Ribosomal protein S2 | 754 | 8 | N |
| Ribosomal_S26e | PF01283 | Ribosomal protein S26e | 194 | 2 | N |
| Ribosomal_S3_C | PF00189 | Ribosomal protein S3, C-terminal domain | 765 | 6 | N |
| Ribosomal_S30 | PF04758 | Ribosomal protein S30 | 177 | 2 | N |
| Ribosomal_S4 | PF00163 | Ribosomal protein S4/S9 N-terminal domain | 555 | 5 | N |
| Ribosomal_S5 | PF00333 | Ribosomal protein S5, N-terminal domain | 601 | 3 | N |
| Ribosomal_S8 | PF00410 | Ribosomal protein S8 | 587 | 3 | N |
| Ribosomal_S9 | PF00380 | Ribosomal protein S9/S16 | 803 | 5 | N |
| Ricin_B_lectin | PF00652 | Ricin-type beta-trefoil lectin domain | 13 | 14 | N |
| RicinB_lectin_2 | PF14200 | Ricin-type beta-trefoil lectin domain-like | 8 | 3 | N |
| Rieske | PF00355 | Rieske [2Fe-2S] domain | 31 | 5 | N |
| RIIa | PF02197 | Regulatory subunit of type II PKA R-subunit | 5 | 12 | N |
| RILP | PF11461 | Rab interacting lysosomal protein | 0 | 2 | N |
| RimK | PF08443 | RimK-like ATP-grasp domain | 10 | 10 | N |
| Rimk_N | PF18030 | RimK PreATP-grasp domain | 4 | 3 | N |
| RIP | PF00161 | Ribosome inactivating protein | 12 | 15 | N |
| RNA_pol_A_bac | PF01000 | RNA polymerase Rpb3/RpoA insert domain | 36 | 16 | N |
| RNA_pol_I_TF | PF04090 | RNA polymerase I specific initiation factor | 1 | 1 | N |
| RNA_pol_L | PF01193 | RNA polymerase Rpb3/Rpb11 dimerisation domain | 13 | 14 | N |
| RNA_pol_Rpb1_1 | PF04997 | RNA polymerase Rpb1, domain 1 | 36 | 8 | N |
| RNA_pol_Rpb1_2 | PF00623 | RNA polymerase Rpb1, domain 2 | 36 | 9 | N |
| RNA_pol_Rpb1_4 | PF05000 | RNA polymerase Rpb1, domain 4 | 23 | 7 | N |
| RNA_pol_Rpb1_5 | PF04998 | RNA polymerase Rpb1, domain 5 | 28 | 14 | N |
| RNA_pol_Rpb1_7 | PF04990 | RNA polymerase Rpb1, domain 7 | 14 | 1 | N |
| RNA_pol_Rpb2_1 | PF04563 | RNA polymerase beta subunit | 32 | 19 | N |
| RNA_pol_Rpb2_2 | PF04561 | RNA polymerase Rpb2, domain 2 | 28 | 5 | N |
| RNA_pol_Rpb2_3 | PF04565 | RNA polymerase Rpb2, domain 3 | 22 | 5 | N |
| RNA_pol_Rpb2_6 | PF00562 | RNA polymerase Rpb2, domain 6 | 36 | 34 | N |
| RNA_pol_Rpb2_7 | PF04560 | RNA polymerase Rpb2, domain 7 | 36 | 3 | N |
| RNA_pol_Rpb4 | PF03874 | RNA polymerase Rpb4 | 19 | 3 | N |
| RNase_H | PF00075 | RNase H | 6 | 1 | N |
| RNase_PH | PF01138 | 3' exoribonuclease family, domain 1 | 2 | 2 | N |
| RNase_PH_C | PF03725 | 3' exoribonuclease family, domain 2 | 2 | 2 | N |
| RNase_T | PF00929 | Exonuclease | 2 | 2 | N |
| RnaseA | PF00074 | Pancreatic ribonuclease | 35 | 3 | N |
| RNPP_C | PF18768 | RNPP family C-terminal domain | 5 | 2 | N |
| Rota_NSP3 | PF01665 | Rotavirus non-structural protein NSP3 | 1 | 1 | N |
| Rota_NSP4 | PF01452 | Rotavirus non structural protein | 0 | 1 | N |
| Rotamase | PF00639 | PPIC-type PPIASE domain | 9 | 9 | N |
| RPA_C | PF08784 | Replication protein A C terminal | 2 | 2 | N |
| RPAP2_Rtr1 | PF04181 | Rtr1/RPAP2 family | 1 | 1 | N |
| RPN1_C | PF18051 | 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal | 6 | 1 | N |
| RPN1_RPN2_N | PF17781 | RPN1 N-terminal domain | 7 | 1 | N |
| Rpn3_C | PF08375 | Proteasome regulatory subunit C-terminal | 5 | 1 | N |
| RPN6_C_helix | PF18503 | 26S proteasome subunit RPN6 C-terminal helix domain | 5 | 1 | N |
| RPN7 | PF10602 | 26S proteasome subunit RPN7 | 4 | 1 | N |
| Rpn9_C | PF18261 | Rpn9 C-terminal helix | 1 | 1 | N |
| RraA-like | PF03737 | Aldolase/RraA | 1 | 1 | N |
| Rrf2 | PF02082 | Iron-dependent Transcriptional regulator | 1 | 1 | N |
| RRM_1 | PF00076 | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) | 48 | 25 | N |
| RRM_8 | PF11835 | RRM-like domain | 4 | 4 | N |
| Rrn6 | PF10214 | RNA polymerase I-specific transcription-initiation factor | 1 | 1 | N |
| rRNA_proc-arch | PF13234 | rRNA-processing arch domain | 2 | 1 | N |
| Rrp40_N | PF18311 | Exosome complex exonuclease Rrp40 N-terminal domain | 0 | 2 | N |
| Rsc14 | PF08586 | RSC complex, Rsc14/Ldb7 subunit | 2 | 2 | N |
| RsfS | PF02410 | Ribosomal silencing factor during starvation | 6 | 1 | N |
| RTT107_BRCT_5 | PF16770 | Regulator of Ty1 transposition protein 107 BRCT domain | 9 | 9 | Y |
| RTT107_BRCT_6 | PF16771 | Regulator of Ty1 transposition protein 107 BRCT domain | 1 | 1 | N |
| RuBisCO_large | PF00016 | Ribulose bisphosphate carboxylase large chain, catalytic domain | 3 | 3 | N |
| RuBisCO_large_N | PF02788 | Ribulose bisphosphate carboxylase large chain, N-terminal domain | 3 | 3 | N |
| RuBisCO_small | PF00101 | Ribulose bisphosphate carboxylase, small chain | 3 | 4 | N |
| Rubredoxin | PF00301 | Rubredoxin | 1 | 2 | N |
| RuvB_N | PF05496 | Holliday junction DNA helicase RuvB P-loop domain | 0 | 8 | N |
| rve | PF00665 | Integrase core domain | 20 | 21 | N |
| RVP | PF00077 | Retroviral aspartyl protease | 102 | 101 | N |
| RVT_1 | PF00078 | Reverse transcriptase (RNA-dependent DNA polymerase) | 14 | 1 | N |
| RWD | PF05773 | RWD domain | 0 | 4 | N |
| RyR | PF02026 | RyR domain | 1 | 1 | N |
| S_100 | PF01023 | S-100/ICaBP type calcium binding domain | 23 | 28 | N |
| S_locus_glycop | PF00954 | S-locus glycoprotein domain | 0 | 1 | N |
| S10_plectin | PF03501 | Plectin/S10 domain | 264 | 5 | N |
| S4 | PF01479 | S4 domain | 640 | 3 | N |
| SabA_adhesion | PF18304 | SabA N-terminal extracellular adhesion domain | 1 | 1 | N |
| SAC3 | PF12209 | Leucine permease transcriptional regulator helical domain | 2 | 1 | N |
| SAC3_GANP | PF03399 | SAC3/GANP family | 1 | 1 | N |
| SAD_SRA | PF02182 | SAD/SRA domain | 2 | 1 | N |
| Sad1_UNC | PF07738 | Sad1 / UNC-like C-terminal | 2 | 9 | N |
| Sas10_Utp3 | PF04000 | Sas10/Utp3/C1D family | 3 | 1 | N |
| SAWADEE | PF16719 | SAWADEE domain | 8 | 8 | N |
| SbcCD_C | PF13558 | Putative exonuclease SbcCD, C subunit | 0 | 2 | N |
| SBP_bac_1 | PF01547 | Bacterial extracellular solute-binding protein | 22 | 11 | N |
| SBP_bac_3 | PF00497 | Bacterial extracellular solute-binding proteins, family 3 | 2 | 2 | N |
| SBP_bac_5 | PF00496 | Bacterial extracellular solute-binding proteins, family 5 Middle | 66 | 66 | N |
| SBP_bac_8 | PF13416 | Bacterial extracellular solute-binding protein | 11 | 5 | N |
| SCRL | PF06876 | Plant self-incompatibility response (SCRL) protein | 0 | 1 | N |
| Sdh_cyt | PF01127 | Succinate dehydrogenase/Fumarate reductase transmembrane subunit | 0 | 1 | N |
| SdrG_C_C | PF10425 | C-terminus of bacterial fibrinogen-binding adhesin | 10 | 10 | N |
| Sds3 | PF08598 | Sds3-like | 0 | 2 | N |
| Sec1 | PF00995 | Sec1 family | 4 | 4 | N |
| Sec23_BS | PF08033 | Sec23/Sec24 beta-sandwich domain | 18 | 11 | N |
| Sec23_helical | PF04815 | Sec23/Sec24 helical domain | 18 | 3 | N |
| Sec23_trunk | PF04811 | Sec23/Sec24 trunk domain | 18 | 2 | N |
| Sec61_beta | PF03911 | Sec61beta family | 13 | 1 | N |
| SecA_DEAD | PF07517 | SecA DEAD-like domain | 2 | 2 | N |
| SecA_PP_bind | PF01043 | SecA preprotein cross-linking domain | 1 | 1 | N |
| SecA_SW | PF07516 | SecA Wing and Scaffold domain | 2 | 1 | N |
| SecB | PF02556 | Preprotein translocase subunit SecB | 4 | 7 | N |
| SecE | PF00584 | SecE/Sec61-gamma subunits of protein translocation complex | 14 | 5 | N |
| SecY | PF00344 | SecY | 25 | 19 | N |
| SelR | PF01641 | SelR domain | 2 | 1 | N |
| Sema | PF01403 | Sema domain | 3 | 1 | N |
| Sema4F_C | PF19428 | Semaphorin 4F C-terminal | 0 | 1 | N |
| SepF | PF04472 | Cell division protein SepF | 3 | 3 | N |
| Serpin | PF00079 | Serpin (serine protease inhibitor) | 32 | 19 | N |
| Serum_albumin | PF00273 | Serum albumin family | 4 | 1 | N |
| SET | PF00856 | SET domain | 106 | 100 | N |
| Sgf11_N | PF18519 | SAGA-associated factor 11 N-terminal domain | 1 | 2 | N |
| SH2 | PF00017 | SH2 domain | 167 | 160 | Y |
| SH2_2 | PF14633 | SH2 domain | 5 | 3 | N |
| SH3_1 | PF00018 | SH3 domain | 114 | 105 | Y |
| SH3_2 | PF07653 | Variant SH3 domain | 7 | 7 | N |
| SH3_3 | PF08239 | Bacterial SH3 domain | 1 | 1 | N |
| SH3_5 | PF08460 | Bacterial SH3 domain | 1 | 1 | N |
| SH3_9 | PF14604 | Variant SH3 domain | 33 | 30 | Y |
| She2p | PF11435 | RNA binding protein She2p | 1 | 2 | N |
| Shigella_OspC | PF06128 | Shigella flexneri OspC protein | 1 | 1 | N |
| SHNi-TPR | PF10516 | SHNi-TPR | 2 | 2 | N |
| SHS2_FTSA | PF02491 | SHS2 domain inserted in FTSA | 1 | 1 | N |
| Sigma70_r1_2 | PF00140 | Sigma-70 factor, region 1.2 | 12 | 4 | N |
| SIKE | PF05769 | SIKE family | 1 | 1 | N |
| Sin3_corepress | PF08295 | Sin3 family co-repressor | 1 | 1 | N |
| Sina | PF03145 | Seven in absentia protein family | 7 | 7 | N |
| SinI | PF08671 | Anti-repressor SinI | 0 | 2 | N |
| SIP1 | PF04938 | Survival motor neuron (SMN) interacting protein 1 (SIP1) | 1 | 6 | N |
| SIR2 | PF02146 | Sir2 family | 111 | 109 | N |
| SKG6 | PF08693 | Transmembrane alpha-helix domain | 0 | 1 | N |
| SKICH | PF17751 | SKICH domain | 0 | 2 | N |
| Skp1 | PF01466 | Skp1 family, dimerisation domain | 16 | 4 | N |
| Skp1_POZ | PF03931 | Skp1 family, tetramerisation domain | 32 | 1 | N |
| SLM4 | PF16818 | Protein SLM4 | 0 | 1 | N |
| SLT | PF01464 | Transglycosylase SLT domain | 6 | 4 | N |
| SLT_beta | PF02258 | Shiga-like toxin beta subunit | 6 | 4 | N |
| SLT_L | PF14718 | Soluble lytic murein transglycosylase L domain | 3 | 2 | N |
| SMC_hinge | PF06470 | SMC proteins Flexible Hinge Domain | 1 | 1 | N |
| SMC_N | PF02463 | RecF/RecN/SMC N terminal domain | 3 | 2 | N |
| SMC_ScpB | PF04079 | Segregation and condensation complex subunit ScpB | 1 | 1 | N |
| SMN | PF06003 | Survival motor neuron protein (SMN) | 2 | 1 | N |
| SNARE | PF05739 | SNARE domain | 0 | 6 | N |
| SNase | PF00565 | Staphylococcal nuclease homologue | 7 | 5 | N |
| SNF2-rel_dom | PF00176 | SNF2-related domain | 11 | 2 | N |
| SNF5 | PF04855 | SNF5 / SMARCB1 / INI1 | 3 | 1 | N |
| SNX17_FERM_C | PF18116 | Sorting Nexin 17 FERM C-terminal domain | 1 | 2 | N |
| Snx8_BAR_dom | PF19566 | Sorting nexin 8/Mvp1 BAR domain | 0 | 1 | N |
| SOAR | PF16533 | STIM1 Orai1-activating region | 1 | 1 | N |
| Sod_Cu | PF00080 | Copper/zinc superoxide dismutase (SODC) | 6 | 5 | N |
| SopD | PF11047 | Salmonella outer protein D | 1 | 1 | N |
| Sortase | PF04203 | Sortase domain | 10 | 10 | N |
| Sortilin_C | PF15901 | Sortilin, neurotensin receptor 3, C-terminal | 4 | 3 | N |
| Sortilin-Vps10 | PF15902 | Sortilin, neurotensin receptor 3, | 4 | 4 | N |
| SpaA | PF17802 | Prealbumin-like fold domain | 2 | 2 | N |
| SPASM | PF13186 | Iron-sulfur cluster-binding domain | 4 | 4 | N |
| Spc24 | PF08286 | Spc24 subunit of Ndc80 | 2 | 4 | N |
| Spidroin_N | PF16763 | Major ampullate spidroin 1, spider silk protein 1, N-term | 1 | 1 | N |
| Spindle_Spc25 | PF08234 | Chromosome segregation protein Spc25 | 2 | 3 | N |
| Spin-Ssty | PF02513 | Spin/Ssty Family | 12 | 12 | Y |
| SPOC | PF07744 | SPOC domain | 5 | 5 | N |
| SPRY | PF00622 | SPRY domain | 37 | 32 | N |
| Spy1 | PF11357 | Cell cycle regulatory protein | 0 | 1 | N |
| Squash | PF00299 | Squash family serine protease inhibitor | 18 | 2 | N |
| SRF-TF | PF00319 | SRF-type transcription factor (DNA-binding and dimerisation domain) | 1 | 1 | N |
| SRP_SPB | PF02978 | Signal peptide binding domain | 20 | 16 | N |
| SRP19 | PF01922 | SRP19 protein | 9 | 1 | N |
| SRP54 | PF00448 | SRP54-type protein, GTPase domain | 16 | 1 | N |
| SSB | PF00436 | Single-strand binding protein family | 1 | 1 | N |
| SspB | PF04386 | Stringent starvation protein B | 4 | 4 | N |
| Ssu72 | PF04722 | Ssu72-like protein | 8 | 8 | N |
| ST7 | PF04184 | ST7 protein | 1 | 1 | N |
| STAG | PF08514 | STAG domain | 1 | 1 | N |
| Stap_Strp_tox_C | PF02876 | Staphylococcal/Streptococcal toxin, beta-grasp domain | 22 | 4 | N |
| Staph_opine_DH | PF10100 | Staphylopine dehydrogenase | 1 | 1 | N |
| Staufen_C | PF16482 | Staufen C-terminal domain | 1 | 2 | N |
| StbA | PF06406 | StbA protein | 1 | 1 | N |
| STE2 | PF02116 | Fungal pheromone mating factor STE2 GPCR | 5 | 4 | N |
| STPPase_N | PF16891 | Serine-threonine protein phosphatase N-terminal domain | 27 | 5 | N |
| Strabismus | PF06638 | Strabismus protein | 3 | 2 | N |
| Striatin | PF08232 | Striatin family | 1 | 2 | N |
| STT3 | PF02516 | Oligosaccharyl transferase STT3 subunit | 13 | 11 | N |
| Suf | PF05843 | Suppressor of forked protein (Suf) | 1 | 1 | N |
| SUFU | PF05076 | Suppressor of fused protein (SUFU) | 4 | 4 | N |
| SUFU_C | PF12470 | Suppressor of Fused Gli/Ci N terminal binding domain | 4 | 3 | N |
| Sulfotransfer_1 | PF00685 | Sulfotransferase domain | 3 | 3 | N |
| Sulfotransfer_3 | PF13469 | Sulfotransferase family | 4 | 4 | N |
| Suppressor_APC | PF11414 | Adenomatous polyposis coli tumour suppressor protein | 1 | 1 | N |
| Surfac_D-trimer | PF09006 | Lung surfactant protein D coiled-coil trimerisation | 0 | 1 | N |
| Surp | PF01805 | Surp module | 0 | 1 | N |
| SusD-like_2 | PF12771 | Starch-binding associating with outer membrane | 3 | 3 | N |
| SusD-like_3 | PF14322 | Starch-binding associating with outer membrane | 6 | 5 | N |
| Sushi | PF00084 | Sushi repeat (SCR repeat) | 2 | 1 | N |
| Sushi_2 | PF09014 | Beta-2-glycoprotein-1 fifth domain | 0 | 1 | N |
| SWIB | PF02201 | SWIB/MDM2 domain | 68 | 62 | Y |
| SWIRM | PF04433 | SWIRM domain | 25 | 4 | N |
| Synaphin | PF05835 | Synaphin protein | 0 | 4 | N |
| Synaptobrevin | PF00957 | Synaptobrevin | 10 | 1 | N |
| Syndecan | PF01034 | Syndecan domain | 5 | 3 | N |
| Syntaxin | PF00804 | Syntaxin | 1 | 6 | N |
| Syntaxin-6_N | PF09177 | Syntaxin 6, N-terminal | 3 | 7 | N |
| Synuclein | PF01387 | Synuclein | 17 | 3 | N |
| T2SS_PulS_OutS | PF09691 | Type II secretion system pilotin lipoprotein (PulS_OutS) | 1 | 1 | N |
| T3SS_needle_E | PF08988 | Type III secretion system, cytoplasmic E component of needle | 0 | 1 | N |
| T4BSS_DotH_IcmK | PF12293 | Putative outer membrane core complex of type IVb secretion | 7 | 1 | N |
| T6SS_TssF | PF05947 | Type VI secretion system, TssF | 1 | 1 | N |
| T6SS_TssG | PF06996 | Type VI secretion, TssG | 1 | 1 | N |
| TACC_C | PF05010 | Transforming acidic coiled-coil-containing protein (TACC), C-terminal | 0 | 2 | N |
| TAF | PF02969 | TATA box binding protein associated factor (TAF) | 21 | 9 | N |
| TAF6_C | PF07571 | TAF6 C-terminal HEAT repeat domain | 1 | 1 | N |
| TAFH | PF07531 | NHR1 homology to TAF | 1 | 1 | N |
| Talin_middle | PF09141 | Talin, middle domain | 2 | 1 | N |
| TAP_C | PF03943 | TAP C-terminal domain | 3 | 2 | N |
| Tat | PF00539 | Transactivating regulatory protein (Tat) | 16 | 3 | N |
| TBD | PF12845 | TBD domain | 3 | 1 | N |
| TBK1_CCD1 | PF18394 | TANK-binding kinase 1 coiled-coil domain 1 | 0 | 1 | N |
| Tcell_CD4_C | PF12104 | T cell CD4 receptor C terminal region | 7 | 1 | N |
| Tcp10_C | PF07202 | T-complex protein 10 C-terminus | 2 | 2 | N |
| TcpF | PF06340 | Vibrio cholerae toxin co-regulated pilus biosynthesis protein F | 1 | 1 | N |
| TCR_zetazeta | PF11628 | T-cell surface glycoprotein CD3 zeta chain | 0 | 1 | N |
| Tctex-1 | PF03645 | Tctex-1 family | 1 | 2 | N |
| TCTP | PF00838 | Translationally controlled tumour protein | 1 | 1 | N |
| TERB2 | PF15101 | Telomere-associated protein TERB2 | 0 | 1 | N |
| TetR_C_32 | PF19344 | Tetracyclin repressor-like, C-terminal domain | 4 | 4 | N |
| TetR_N | PF00440 | Bacterial regulatory proteins, tetR family | 9 | 5 | N |
| Tfb2 | PF03849 | Transcription factor Tfb2 | 1 | 3 | N |
| TFIIB | PF00382 | Transcription factor TFIIB repeat | 7 | 3 | N |
| TFIIF_alpha | PF05793 | Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) | 8 | 2 | N |
| TFR_dimer | PF04253 | Transferrin receptor-like dimerisation domain | 1 | 1 | N |
| TGF_beta | PF00019 | Transforming growth factor beta like domain | 1 | 1 | N |
| ThiF | PF00899 | ThiF family | 9 | 8 | N |
| Thioesterase | PF00975 | Thioesterase domain | 3 | 3 | N |
| Thionin | PF00321 | Plant thionin | 2 | 3 | N |
| Thioredoxin | PF00085 | Thioredoxin | 14 | 9 | N |
| Thioredoxin_6 | PF13848 | Thioredoxin-like domain | 1 | 1 | N |
| THOC7 | PF05615 | Tho complex subunit 7 | 0 | 3 | N |
| Thrombin_light | PF09396 | Thrombin light chain | 342 | 2 | N |
| Thymidylat_synt | PF00303 | Thymidylate synthase | 2 | 2 | N |
| TIG | PF01833 | IPT/TIG domain | 3 | 1 | N |
| TIG_SUH | PF20144 | TIG domain | 5 | 2 | N |
| Tim17 | PF02466 | Tim17/Tim22/Tim23/Pmp24 family | 4 | 9 | N |
| TINF2_N | PF14973 | TERF1-interacting nuclear factor 2 N-terminus | 1 | 1 | N |
| TIP41 | PF04176 | TIP41-like family | 1 | 1 | N |
| TIP49 | PF06068 | TIP49 P-loop domain | 4 | 4 | N |
| TipAS | PF07739 | TipAS antibiotic-recognition domain | 2 | 2 | N |
| TIR_2 | PF13676 | TIR domain | 1 | 1 | N |
| Tli4_C | PF18426 | Tle cognate immunity protein 4 C-terminal domain | 1 | 1 | N |
| Tlr3_TMD | PF17968 | Toll-like receptor 3 trans-membrane domain | 0 | 2 | N |
| TNF | PF00229 | TNF(Tumour Necrosis Factor) family | 6 | 8 | N |
| TNFR_16_TM | PF18422 | Tumor necrosis factor receptor member 16 trans-membrane domain | 0 | 3 | N |
| TNFR_c6 | PF00020 | TNFR/NGFR cysteine-rich region | 1 | 1 | N |
| TniB | PF05621 | Bacterial TniB protein | 2 | 2 | N |
| TOC159_MAD | PF11886 | Translocase of chloroplast 159/132, membrane anchor domain | 3 | 3 | N |
| TolA_bind_tri | PF16331 | TolA binding protein trimerisation | 0 | 2 | N |
| Tom22 | PF04281 | Mitochondrial import receptor subunit Tom22 | 0 | 1 | N |
| Tom6 | PF17112 | Mitochondrial import receptor subunit Tom6, fungal | 0 | 1 | N |
| TonB_2 | PF13103 | TonB C terminal | 1 | 1 | N |
| TonB_dep_Rec | PF00593 | TonB dependent receptor | 20 | 20 | N |
| TOP_N | PF19310 | Neurolysin/Thimet oligopeptidase, N-terminal domain | 3 | 1 | N |
| Torsin | PF06309 | Torsin | 1 | 1 | N |
| Toxin_2 | PF00451 | Scorpion short toxin, BmKK2 | 4 | 1 | N |
| Toxin_36 | PF10550 | Conantokin toxin | 15 | 1 | N |
| Toxin_8 | PF07365 | Alpha conotoxin precursor | 62 | 2 | N |
| Toxin_R_bind_C | PF07951 | Clostridium neurotoxin, C-terminal receptor binding | 9 | 10 | N |
| Toxin_R_bind_N | PF07953 | Clostridium neurotoxin, N-terminal receptor binding | 9 | 2 | N |
| Toxin_TOLIP | PF00087 | Snake toxin and toxin-like protein | 18 | 18 | N |
| TP_methylase | PF00590 | Tetrapyrrole (Corrin/Porphyrin) Methylases | 3 | 3 | N |
| TPR_1 | PF00515 | Tetratricopeptide repeat | 54 | 37 | N |
| TPR_11 | PF13414 | TPR repeat | 65 | 45 | N |
| TPR_12 | PF13424 | Tetratricopeptide repeat | 45 | 31 | N |
| TPR_16 | PF13432 | Tetratricopeptide repeat | 23 | 16 | N |
| TPR_19 | PF14559 | Tetratricopeptide repeat | 27 | 3 | N |
| TPR_2 | PF07719 | Tetratricopeptide repeat | 25 | 31 | N |
| TPR_3 | PF07720 | Tetratricopeptide repeat | 4 | 4 | N |
| TPR_5 | PF12688 | Tetratrico peptide repeat | 0 | 1 | N |
| TPR_7 | PF13176 | Tetratricopeptide repeat | 0 | 1 | N |
| TQ | PF18202 | T-Q ester bond containing domain | 1 | 1 | N |
| Tra_M | PF05261 | TraM protein, DNA-binding | 1 | 1 | N |
| TRAF_BIRC3_bd | PF16673 | TNF receptor-associated factor BIRC3 binding domain | 4 | 1 | N |
| TraK | PF06586 | TraK protein | 1 | 1 | N |
| Trans_reg_C | PF00486 | Transcriptional regulatory protein, C terminal | 1 | 1 | N |
| Transcript_VP30 | PF11507 | Ebola virus-specific transcription factor VP30 | 3 | 3 | N |
| Transferrin | PF00405 | Transferrin | 35 | 17 | N |
| Transglut_core | PF01841 | Transglutaminase-like superfamily | 12 | 11 | N |
| Transglut_prok | PF09017 | Microbial transglutaminase | 1 | 1 | N |
| Transgly | PF00912 | Transglycosylase | 7 | 1 | N |
| Transketolase_C | PF02780 | Transketolase, C-terminal domain | 3 | 2 | N |
| Transp_inhibit | PF18791 | Transport inhibitor response 1 protein domain | 6 | 6 | N |
| Transpeptidase | PF00905 | Penicillin binding protein transpeptidase domain | 12 | 7 | N |
| Transposase_1 | PF01359 | Transposase (partial DDE domain) | 1 | 1 | N |
| Transthyretin | PF00576 | HIUase/Transthyretin family | 5 | 4 | N |
| TrbI | PF03743 | Bacterial conjugation TrbI-like protein | 6 | 3 | N |
| TRF | PF08558 | Telomere repeat binding factor (TRF) | 9 | 9 | N |
| Tricorn_C1 | PF14684 | Tricorn protease C1 domain | 2 | 2 | N |
| TrkA_TMD | PF18613 | Tyrosine kinase receptor A trans-membrane domain | 0 | 1 | N |
| tRNA_anti-codon | PF01336 | OB-fold nucleic acid binding domain | 0 | 3 | N |
| tRNA-synt_2 | PF00152 | tRNA synthetases class II (D, K and N) | 0 | 3 | N |
| Tropomodulin | PF03250 | Tropomodulin | 0 | 1 | N |
| Tropomyosin | PF00261 | Tropomyosin | 0 | 6 | N |
| Tropomyosin_1 | PF12718 | Tropomyosin like | 0 | 3 | N |
| Troponin | PF00992 | Troponin | 10 | 3 | N |
| TruD | PF01142 | tRNA pseudouridine synthase D (TruD) | 3 | 1 | N |
| Tryp_alpha_amyl | PF00234 | Protease inhibitor/seed storage/LTP family | 7 | 1 | N |
| Trypsin | PF00089 | Trypsin | 634 | 684 | N |
| Trypsin_2 | PF13365 | Trypsin-like peptidase domain | 40 | 32 | N |
| TSC22 | PF01166 | TSC-22/dip/bun family | 0 | 1 | N |
| TSP_NTD | PF17804 | Tail specific protease N-terminal domain | 1 | 1 | N |
| TSP9 | PF11493 | Thylakoid soluble phosphoprotein TSP9 | 1 | 1 | N |
| TTD | PF12148 | Tandem tudor domain within UHRF1 | 6 | 6 | N |
| TTL | PF03133 | Tubulin-tyrosine ligase family | 5 | 4 | N |
| Tubulin | PF00091 | Tubulin/FtsZ family, GTPase domain | 7 | 6 | N |
| Tubulin_C | PF03953 | Tubulin C-terminal domain | 6 | 6 | N |
| Tubulin-binding | PF00418 | Tau and MAP protein, tubulin-binding repeat | 21 | 7 | N |
| TUDOR | PF00567 | Tudor domain | 12 | 12 | N |
| Tudor_2 | PF18104 | Jumonji domain-containing protein 2A Tudor domain | 12 | 12 | N |
| Tudor_4 | PF18358 | Histone methyltransferase Tudor domain | 7 | 7 | N |
| Tudor_5 | PF18359 | Histone methyltransferase Tudor domain 1 | 7 | 7 | N |
| Tudor-knot | PF11717 | RNA binding activity-knot of a chromodomain | 4 | 4 | N |
| Tugs | PF17840 | Tethering Ubl4a to BAGS domain | 0 | 1 | N |
| Tyr-DNA_phospho | PF06087 | Tyrosyl-DNA phosphodiesterase | 3 | 3 | N |
| Tyrosinase | PF00264 | Common central domain of tyrosinase | 4 | 3 | N |
| U5_2-snRNA_bdg | PF10597 | U5-snRNA binding site 2 of PrP8 | 2 | 2 | N |
| U6-snRNA_bdg | PF10596 | U6-snRNA interacting domain of PrP8 | 2 | 1 | N |
| UB2H | PF14814 | Bifunctional transglycosylase second domain | 1 | 1 | N |
| UBA | PF00627 | UBA/TS-N domain | 1 | 2 | N |
| UBA_4 | PF14555 | UBA-like domain | 2 | 1 | N |
| UbiD | PF01977 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase | 1 | 1 | N |
| ubiquitin | PF00240 | Ubiquitin family | 238 | 50 | N |
| Ubiquitin_3 | PF14836 | Ubiquitin-like domain | 1 | 1 | N |
| U-box | PF04564 | U-box domain | 3 | 1 | N |
| UCH | PF00443 | Ubiquitin carboxyl-terminal hydrolase | 3 | 1 | N |
| UCR_14kD | PF02271 | Ubiquinol-cytochrome C reductase complex 14kD subunit | 9 | 3 | N |
| UCR_Fe-S_N | PF10399 | Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal | 15 | 2 | N |
| UCR_hinge | PF02320 | Ubiquinol-cytochrome C reductase hinge protein | 9 | 1 | N |
| UCR_TM | PF02921 | Ubiquinol cytochrome reductase transmembrane region | 9 | 3 | N |
| UCR_UQCRX_QCR9 | PF05365 | Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like | 9 | 2 | N |
| UcrQ | PF02939 | UcrQ family | 9 | 2 | N |
| UDG | PF03167 | Uracil DNA glycosylase superfamily | 2 | 2 | N |
| UEV | PF05743 | UEV domain | 11 | 11 | N |
| UFC1 | PF08694 | Ubiquitin-fold modifier-conjugating enzyme 1 | 2 | 2 | N |
| Ufm1 | PF03671 | Ubiquitin fold modifier 1 protein | 1 | 1 | N |
| UL45 | PF05473 | UL45 protein, carbohydrate-binding C-type lectin-like | 1 | 1 | N |
| UPAR_LY6 | PF00021 | u-PAR/Ly-6 domain | 4 | 4 | N |
| UQ_con | PF00179 | Ubiquitin-conjugating enzyme | 12 | 8 | N |
| Use1 | PF09753 | Membrane fusion protein Use1 | 2 | 4 | N |
| USP7_ICP0_bdg | PF12436 | ICP0-binding domain of Ubiquitin-specific protease 7 | 5 | 8 | N |
| UTP25 | PF06862 | Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 | 0 | 1 | N |
| UVR | PF02151 | UvrB/uvrC motif | 0 | 2 | N |
| UvrD_C_2 | PF13538 | UvrD-like helicase C-terminal domain | 1 | 1 | N |
| Vac_ImportDeg | PF09783 | Vacuolar import and degradation protein | 11 | 11 | N |
| VanY | PF02557 | D-alanyl-D-alanine carboxypeptidase | 1 | 1 | N |
| Vasohibin | PF14822 | Vasohibin | 6 | 7 | N |
| VASP_tetra | PF08776 | VASP tetramerisation domain | 0 | 1 | N |
| V-ATPase_G_2 | PF16999 | Vacuolar (H+)-ATPase G subunit | 1 | 1 | N |
| VBS | PF08913 | Vinculin Binding Site | 4 | 2 | N |
| VEGFR-2_TMD | PF17988 | VEGFR-2 Transmembrane domain | 0 | 3 | N |
| VEK-30 | PF12107 | Plasminogen (Pg) ligand in fibrinolytic pathway | 3 | 1 | N |
| Vfa1 | PF08432 | AAA-ATPase Vps4-associated protein 1 | 2 | 1 | N |
| Vg_Tdu | PF07545 | Vestigial/Tondu family | 0 | 1 | N |
| VGCC_beta4Aa_N | PF12052 | Voltage gated calcium channel subunit beta domain 4Aa N terminal | 7 | 1 | N |
| VHL | PF01847 | VHL beta domain | 8 | 9 | N |
| VHP | PF02209 | Villin headpiece domain | 4 | 5 | N |
| VHS | PF00790 | VHS domain | 12 | 12 | N |
| Vinculin | PF01044 | Vinculin family | 23 | 20 | N |
| VP4_2 | PF08935 | Viral protein VP4 subunit | 0 | 1 | N |
| VPR | PF00522 | VPR/VPX protein | 8 | 2 | N |
| Vps23_core | PF09454 | Vps23 core domain | 1 | 1 | N |
| Vps26 | PF03643 | Vacuolar protein sorting-associated protein 26 | 5 | 5 | N |
| VPS28 | PF03997 | VPS28 protein | 1 | 1 | N |
| Vps39_2 | PF10367 | Vacuolar sorting protein 39 domain 2 | 0 | 1 | N |
| Vps4_C | PF09336 | Vps4 C terminal oligomerisation domain | 9 | 1 | N |
| Vps51 | PF08700 | Vps51/Vps67 | 3 | 1 | N |
| VRP3 | PF03536 | Salmonella virulence-associated 28kDa protein | 2 | 2 | N |
| V-set | PF07686 | Immunoglobulin V-set domain | 1216 | 999 | N |
| V-set_2 | PF15910 | ICOS V-set domain | 47 | 45 | N |
| Vta1 | PF04652 | Vta1 like | 6 | 4 | N |
| VWA | PF00092 | von Willebrand factor type A domain | 3 | 3 | N |
| Waikav_capsid_1 | PF12264 | Waikavirus capsid protein 1 | 3 | 3 | N |
| WD40 | PF00400 | WD domain, G-beta repeat | 595 | 168 | N |
| WD40_like | PF17005 | WD40-like domain | 1 | 1 | N |
| WGG | PF10273 | Pre-rRNA-processing protein TSR2 | 1 | 1 | N |
| WH1 | PF00568 | WH1 domain | 17 | 17 | Y |
| WH2 | PF02205 | WH2 motif | 5 | 1 | N |
| WIYLD | PF10440 | Ubiquitin-binding WIYLD domain | 0 | 1 | N |
| WRW | PF10206 | Mitochondrial F1F0-ATP synthase, subunit f | 5 | 2 | N |
| WW | PF00397 | WW domain | 64 | 59 | Y |
| WXG100 | PF06013 | Proteins of 100 residues with WXG | 3 | 1 | N |
| XFP_C | PF09363 | XFP C-terminal domain | 0 | 1 | N |
| Xlink | PF00193 | Extracellular link domain | 1 | 1 | N |
| XRCC4 | PF06632 | DNA double-strand break repair and V(D)J recombination protein XRCC4 | 2 | 1 | N |
| Y_phosphatase | PF00102 | Protein-tyrosine phosphatase | 46 | 46 | N |
| Y_phosphatase2 | PF03162 | Tyrosine phosphatase family | 1 | 1 | N |
| YAF2_RYBP | PF17219 | Yaf2/RYBP C-terminal binding motif | 0 | 1 | N |
| YBD | PF17725 | YAP binding domain | 6 | 23 | N |
| YbgT_YccB | PF08173 | Membrane bound YbgT-like protein | 3 | 1 | N |
| YcaO | PF02624 | YcaO cyclodehydratase, ATP-ad Mg2+-binding | 1 | 1 | N |
| Ycf9 | PF01737 | YCF9 | 72 | 80 | N |
| YEATS | PF03366 | YEATS family | 35 | 34 | Y |
| Yippee-Mis18 | PF03226 | Yippee zinc-binding/DNA-binding /Mis18, centromere assembly | 9 | 10 | N |
| YjeF_N | PF03853 | YjeF-related protein N-terminus | 21 | 21 | N |
| YkuD | PF03734 | L,D-transpeptidase catalytic domain | 2 | 2 | N |
| YoeB_toxin | PF06769 | YoeB-like toxin of bacterial type II toxin-antitoxin system | 5 | 1 | N |
| YopH_N | PF09013 | YopH, N-terminal | 1 | 1 | N |
| YscJ_FliF_C | PF08345 | Flagellar M-ring protein C-terminal | 5 | 2 | N |
| z-alpha | PF02295 | Adenosine deaminase z-alpha domain | 1 | 1 | N |
| ZapB | PF06005 | Cell division protein ZapB | 13 | 24 | N |
| ZapD | PF07072 | Cell division protein | 1 | 1 | N |
| zf-A20 | PF01754 | A20-like zinc finger | 0 | 1 | N |
| zf-C2H2 | PF00096 | Zinc finger, C2H2 type | 16 | 1 | N |
| zf-C3HC4_3 | PF13920 | Zinc finger, C3HC4 type (RING finger) | 0 | 1 | N |
| zf-C4_ClpX | PF06689 | ClpX C4-type zinc finger | 3 | 1 | N |
| zf-C5HC2 | PF02928 | C5HC2 zinc finger | 6 | 2 | N |
| zf-CCCH | PF00642 | Zinc finger C-x8-C-x5-C-x3-H type (and similar) | 1 | 1 | N |
| zf-CCHC | PF00098 | Zinc knuckle | 13 | 1 | N |
| zf-CW | PF07496 | CW-type Zinc Finger | 16 | 11 | Y |
| zf-DBF | PF07535 | DBF zinc finger | 1 | 1 | N |
| zf-HC5HC2H_2 | PF13832 | PHD-zinc-finger like domain | 1 | 1 | N |
| zf-MYND | PF01753 | MYND finger | 6 | 1 | N |
| zf-MYST | PF17772 | MYST family zinc finger domain | 2 | 1 | N |
| zf-RING_5 | PF14634 | zinc-RING finger domain | 0 | 1 | N |
| zf-Sec23_Sec24 | PF04810 | Sec23/Sec24 zinc finger | 18 | 12 | N |
| zf-TAZ | PF02135 | TAZ zinc finger | 8 | 9 | N |
| zf-UBP | PF02148 | Zn-finger in ubiquitin-hydrolases and other protein | 1 | 1 | N |
| zf-UBR | PF02207 | Putative zinc finger in N-recognin (UBR box) | 15 | 17 | Y |
| zf-WRNIP1_ubi | PF18279 | Werner helicase-interacting protein 1 ubiquitin-binding domain | 1 | 1 | N |
| ZipA_C | PF04354 | ZipA, C-terminal FtsZ-binding domain | 1 | 1 | N |
| Zmiz1_N | PF18028 | Zmiz1 N-terminal tetratricopeptide repeat domain | 4 | 6 | N |
| Zn-C2H2_12 | PF18112 | Autophagy receptor zinc finger-C2H2 domain | 0 | 1 | N |
| ZT_dimer | PF16916 | Dimerisation domain of Zinc Transporter | 1 | 1 | N |
| ZZ | PF00569 | Zinc finger, ZZ type | 7 | 6 | N |