PyIgClassify2: Canonical Clusters of Antibody CDR Loop Conformations

PyIgClassify2: Classification of Antibody CDR Conformations

CDR Structures for H3-12-3

Summary info for H3-12-3
Loop	# of Structures	% of Loop Length	Median PDB	Consensus Sequence	# of Unique Seq	% of Unique Seq	Gene	Loop Conformation	Median Angle	Consensus Sequence Logo
H3-12-3	42	2.89	2H_7LY0H	ARGvyGtyYFDY	14	3.61	heavy	BBBBBLBABBAB	15

Structures in cluster H3-12-3
Cluster	PDB	Resolution	Gene	PDB Species	Frame Germline	Frame %	CDR Germline	CDR %	Sequence	Ramachandran	Distance(°)
H3-12-3	7LY0H	EM	heavy	Homo.sapiens	Hu_IGHV3-33*01	97.2	Hu_IGHV3-33*01	100.0	ARAVAGEWYFDY	BBBBBLBABBAB	12
H3-12-3	7LY2N	EM	heavy	Homo.sapiens	Hu_IGHV3-33*01	97.2	Hu_IGHV3-33*01	100.0	ARAVAGEWYFDY	BBBBBLBABBAB	12
H3-12-3	7LY2G	EM	heavy	Homo.sapiens	Hu_IGHV3-33*01	97.2	Hu_IGHV3-33*01	100.0	ARAVAGEWYFDY	BBBBBLBABBAB	12
H3-12-3	7LY2H	EM	heavy	Homo.sapiens	Hu_IGHV3-33*01	97.2	Hu_IGHV3-33*01	100.0	ARAVAGEWYFDY	BBBBBLBABBAB	12
H3-12-3	7N3FH	1.9	heavy	Homo.sapiens	Hu_IGHV5-51*01	93.2	Hu_IGHV5-51*01	100.0	ARGVAVDWYFDL	BBBBBEBBBBAB	23
H3-12-3	4JZOC	2.22	heavy	Homo.sapiens	Hu_IGHV1-69*01	90.4	Hu_IGHV1-69*01	100.0	ARGPLSRGYYDY	BBBBBLBABBAB	18
H3-12-3	4JZOA	2.22	heavy	Homo.sapiens	Hu_IGHV1-69*01	90.4	Hu_IGHV1-69*01	100.0	ARGPLSRGYYDY	BBBBBLBABBAB	18
H3-12-3	4JZOG	2.22	heavy	Homo.sapiens	Hu_IGHV1-69*01	90.4	Hu_IGHV1-69*01	100.0	ARGPLSRGYYDY	BBBBBLBABBAB	16
H3-12-3	4Z0XB	2	heavy	Homo.sapiens	Hu_IGHV1-69*01	93.1	Hu_IGHV1-69*01	100.0	ARGPLSRGYYDY	BBBBBLBABBAB	20
H3-12-3	7LY3D	3	heavy	Homo.sapiens	Hu_IGHV3-33*01	95.9	Hu_IGHV3-33*01	100.0	ARAVAGEWYFDY	BBBBBLBABBAB	14
H3-12-3	7LY3F	3	heavy	Homo.sapiens	Hu_IGHV3-33*01	95.9	Hu_IGHV3-33*01	100.0	ARAVAGEWYFDY	BBBBBLBABBAB	15
H3-12-3	3LD8C	2.7	heavy	Cricetulus.migratorius	Mo_IGHV3-2*02	87.5	Mo_IGHV3-2*02	100.0	ARRDYGTYYFDY	BBBBBLBABBAB	16
H3-12-3	3LDBC	2.7	heavy	Cricetulus.migratorius	Mo_IGHV3-2*02	87.5	Mo_IGHV3-2*02	100.0	ARRDYGTYYFDY	BBBBBLBABBAB	15
H3-12-3	6O9ID	2.6	heavy	Homo.sapiens	Mo_IGHV1S81*01	96.7	Mo_IGHV1S81*01	0.0	ARFYYGTSWFAY	BBBBBLBABBAB	20
H3-12-3	6EYNH	2.4	heavy	Homo.sapiens	Mo_IGHV1-7*01	89.0	Mo_IGHV1-7*01	100.0	ARQEYRHSWFAY	BBBBBLBABBAB	16
H3-12-3	6EYOH	3.7	heavy	Homo.sapiens	Mo_IGHV1-7*01	89.0	Mo_IGHV1-7*01	100.0	ARQEYRHSWFAY	BBBBBLBABBAB	16
H3-12-3	6EYNB	2.4	heavy	Homo.sapiens	Mo_IGHV1-7*01	89.0	Mo_IGHV1-7*01	100.0	ARQEYRHSWFAY	BBBBBLBABBAB	18
H3-12-3	6EYOI	3.7	heavy	Homo.sapiens	Mo_IGHV1-7*01	89.0	Mo_IGHV1-7*01	100.0	ARQEYRHSWFAY	BBBBBLBABBAB	21
H3-12-3	6EYND	2.4	heavy	Homo.sapiens	Mo_IGHV1-7*01	89.0	Mo_IGHV1-7*01	100.0	ARQEYRHSWFAY	BBBBBLBABBAB	16
H3-12-3	7CE2Z	2.01	heavy	Homo.sapiens	Hu_IGHV4-59*01	89.0	Hu_IGHV4-59*01	100.0	ARDKYQTDVSDI	BBBBBLBABBAB	13
H3-12-3	2VL5A	2.1	heavy	Mus.musculus	Mo_IGHV1S82*01	95.1	Mo_IGHV1S82*01	0.0	ARLKPGGTWFAY	BBBBBLBABBAB	16
H3-12-3	2Y5TA	2.2	heavy	Mus.musculus	Mo_IGHV1S82*01	95.1	Mo_IGHV1S82*01	0.0	ARLKPGGTWFAY	BBBBBLBABBAB	15
H3-12-3	2VL5C	2.1	heavy	Mus.musculus	Mo_IGHV1S82*01	95.1	Mo_IGHV1S82*01	0.0	ARLKPGGTWFAY	BBBBBLBABBAB	17
H3-12-3	6DFIH	2.48	heavy	Homo.sapiens	Hu_IGHV4-59*01	90.4	Hu_IGHV4-59*01	100.0	ARNQPGGRAFDY	BBBBBLBABBAB	15
H3-12-3	6DFJH	2.07	heavy	Homo.sapiens	Hu_IGHV4-59*01	90.4	Hu_IGHV4-59*01	100.0	ARNQPGGRAFDY	BBBBBLBABBAB	14
H3-12-3	3HMWH	3	heavy	Homo.sapiens	Hu_IGHV5-51*02	91.8	Hu_IGHV5-51*02	100.0	ARRRPGQGYFDF	BBBBBLBABBAB	19
H3-12-3	3S88H	3.351	heavy	Mus.musculus	Mo_IGHV5-12-1*01	91.8	Mo_IGHV5-12-1*01	100.0	ARQLYGNSFFDY	BBBBBLBABBAB	17
H3-12-3	3VE0A	3.353	heavy	Mus.musculus	Mo_IGHV5-12-1*01	91.8	Mo_IGHV5-12-1*01	100.0	ARQLYGNSFFDY	BBBBBLBABBAB	16
H3-12-3	4DGIH	2.4	heavy	Mus.musculus	Mo_IGHV1S78*01	93.4	Mo_IGHV1S78*01	0.0	SRSGYGYYAMEY	BBBBBLBABBAB	18
H3-12-3	4H88H	1.9	heavy	Mus.musculus	Mo_IGHV1S78*01	93.4	Mo_IGHV1S78*01	0.0	SRSGYGYYAMEY	BBBBBLBABBAB	18
H3-12-3	4MA7H	1.97	heavy	Mus.musculus	Mo_IGHV1S78*01	93.4	Mo_IGHV1S78*01	0.0	SRSGYGYYAMEY	BBBBBLBABBAB	18
H3-12-3	4MA8H	2.2	heavy	Mus.musculus	Mo_IGHV1S78*01	93.4	Mo_IGHV1S78*01	0.0	SRSGYGYYAMEY	BBBBBLBABBAB	18
H3-12-3	4YX2H	2.194	heavy	Mus.musculus	Mo_IGHV1S78*01	93.4	Mo_IGHV1S78*01	0.0	SRSGYGYYAMEY	BBBBBLBABBAB	20
H3-12-3	4YXHH	2.7	heavy	Mus.musculus	Mo_IGHV1S78*01	93.4	Mo_IGHV1S78*01	0.0	SRSGYGYYAMEY	BBBBBLBABBAB	18
H3-12-3	4YXKH	2.805	heavy	Mus.musculus	Mo_IGHV1S78*01	93.4	Mo_IGHV1S78*01	0.0	SRSGYGYYAMEY	BBBBBLBABBAB	18
H3-12-3	4YXLH	2.604	heavy	Mus.musculus	Mo_IGHV1S78*01	93.4	Mo_IGHV1S78*01	0.0	SRSGYGYYAMEY	BBBBBLBABBAB	18
H3-12-3	5EZIH	1.61	heavy	Homo.sapiens	Mo_IGHV4-2*02	97.2	Mo_IGHV4-2*02	100.0	ARYGSYVYAMDY	BBBBBLBABBAB	12
H3-12-3	5EZJA	1.95	heavy	Homo.sapiens	Mo_IGHV4-2*02	97.2	Mo_IGHV4-2*02	100.0	ARYGSYVYAMDY	BBBBBLBBBBAB	15
H3-12-3	5EZLA	2.43	heavy	Mus.musculus	Mo_IGHV4-2*02	97.2	Mo_IGHV4-2*02	100.0	ARYGSYVYAMDY	BBBBBLBBBBAB	12
H3-12-3	5EZOH	3.63	heavy	Homo.sapiens	Mo_IGHV4-2*02	97.2	Mo_IGHV4-2*02	100.0	ARYGSYVYAMDY	BBBBBLBABBAB	13
H3-12-3	5EZLH	2.43	heavy	Mus.musculus	Mo_IGHV4-2*02	97.2	Mo_IGHV4-2*02	100.0	ARYGSYVYAMDY	BBBBBLBBBBAB	11
H3-12-3	1LK3H	1.91	heavy	Rattus.norvegicus	Ra_IGHV1-38*01	91.8	Ra_IGHV1-38*01	100.0	TRGVPGNNWFPY	BBBBBLBBBBAB	21

Site developed by the Antibody Team at the lab of Roland Dunbrack. Last updated on Oct. 13, 2022